Disruption of proteostasis causes IRE1 mediated reprogramming of alveolar epithelial cells

Disruption of alveolar type 2 cell (AEC2) protein quality control has been implicated in chronic lung diseases, including pulmonary fibrosis (PF). We previously reported the in vivo modeling of a clinical surfactant protein C (SP-C) mutation that led to AEC2 endoplasmic reticulum (ER) stress and spo...

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Detalles Bibliográficos
Autores principales: Katzen, Jeremy, Rodriguez, Luis, Tomer, Yaniv, Babu, Apoorva, Zhao, Ming, Murthy, Aditi, Carson, Paige, Barrett, Matthew, Basil, Maria C., Carl, Justine, Leach, John P., Morley, Michael, McGraw, Matthew D., Mulugeta, Surafel, Pelura, Timothy, Rosen, Glenn, Morrisey, Edward E., Beers, Michael F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618079/
https://www.ncbi.nlm.nih.gov/pubmed/36252035
http://dx.doi.org/10.1073/pnas.2123187119

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