Loss of Rai1 enhances hippocampal excitability and epileptogenesis in mouse models of Smith–Magenis syndrome

Hyperexcitability of brain circuits is a common feature of autism spectrum disorders (ASDs). Genetic deletion of a chromatin-binding protein, retinoic acid induced 1 (RAI1), causes Smith–Magenis syndrome (SMS). SMS is a syndromic ASD associated with intellectual disability, autistic features, malada...

Descripción completa

Detalles Bibliográficos
Autores principales: Chang, Ya-Ting, Kowalczyk, Max, Fogerson, P. Michelle, Lee, Yu-Ju, Haque, Minza, Adams, Eliza L., Wang, David C., DeNardo, Laura A., Tessier-Lavigne, Marc, Huguenard, John R., Luo, Liqun, Huang, Wei-Hsiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618093/
https://www.ncbi.nlm.nih.gov/pubmed/36256819
http://dx.doi.org/10.1073/pnas.2210122119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618093/
https://www.ncbi.nlm.nih.gov/pubmed/36256819
http://dx.doi.org/10.1073/pnas.2210122119

Ejemplares similares