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Loss of Rai1 enhances hippocampal excitability and epileptogenesis in mouse models of Smith–Magenis syndrome

Hyperexcitability of brain circuits is a common feature of autism spectrum disorders (ASDs). Genetic deletion of a chromatin-binding protein, retinoic acid induced 1 (RAI1), causes Smith–Magenis syndrome (SMS). SMS is a syndromic ASD associated with intellectual disability, autistic features, malada...

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Detalles Bibliográficos
Autores principales:	Chang, Ya-Ting, Kowalczyk, Max, Fogerson, P. Michelle, Lee, Yu-Ju, Haque, Minza, Adams, Eliza L., Wang, David C., DeNardo, Laura A., Tessier-Lavigne, Marc, Huguenard, John R., Luo, Liqun, Huang, Wei-Hsiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618093/ https://www.ncbi.nlm.nih.gov/pubmed/36256819 http://dx.doi.org/10.1073/pnas.2210122119

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