Ring-fused 2-pyridones effective against multidrug-resistant Gram-positive pathogens and synergistic with standard-of-care antibiotics

The alarming rise of multidrug-resistant Gram-positive bacteria has precipitated a healthcare crisis, necessitating the development of new antimicrobial therapies. Here we describe a new class of antibiotics based on a ring-fused 2-pyridone backbone, which are active against vancomycin-resistant ent...

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Detalles Bibliográficos
Autores principales: Nye, Taylor M., Tükenmez, Hasan, Singh, Pardeep, Flores-Mireles, Ana L., Obernuefemann, Chloe L. P., Pinkner, Jerome S., Sarkar, Souvik, Bonde, Mari, Lindgren, Anders E. G., Dodson, Karen W., Johansson, Jörgen, Almqvist, Fredrik, Caparon, Michael G., Hultgren, Scott J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618150/
https://www.ncbi.nlm.nih.gov/pubmed/36252016
http://dx.doi.org/10.1073/pnas.2210912119

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