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Antiphospholipid antibodies in healthy Serbian middle-aged subjects: Preliminary data
BACKGROUND: The investigation of the prevalence of the IgG and the IgM isotypes of anticardiolipin (aCL) and antib2glycoprotein I (ab2gpI) Abs in healthy Serbian middleaged subjects was the main goal of our study. In addition, we analyzed the potential associations of above-mentioned Abs with serum...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Society of Medical Biochemists of Serbia, Belgrade
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618332/ https://www.ncbi.nlm.nih.gov/pubmed/36381077 http://dx.doi.org/10.5937/jomb0-35642 |
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author | Bećarević, Mirjana B. Jovičić, Snežana Ignjatović, Svetlana D. Mirković, Duško |
author_facet | Bećarević, Mirjana B. Jovičić, Snežana Ignjatović, Svetlana D. Mirković, Duško |
author_sort | Bećarević, Mirjana B. |
collection | PubMed |
description | BACKGROUND: The investigation of the prevalence of the IgG and the IgM isotypes of anticardiolipin (aCL) and antib2glycoprotein I (ab2gpI) Abs in healthy Serbian middleaged subjects was the main goal of our study. In addition, we analyzed the potential associations of above-mentioned Abs with serum proteins and lipids/lipoproteins. METHODS: Forty healthy subjects were included in our study. Obesity (BMI 30 kg/m2) was present in 8/40 (20%) subjects. Titers of analyzed Abs were measured by ELISA. RESULTS: The prevalence of IgG and IgM ab2gpI Abs was 5% and 12.5%, respectively, while the prevalence of IgM aCL was 10%. The IgG ab2gpI Abs were significantly different between subjects with normal triglycerides levels and those with hypertriglyceridemia (Mann-Whitney, P = 0.014). The significant difference in hsCRP concentrations was observed between subjects with the increased levels of the IgM isotype of aCL Abs and those with normal IgM aCL values (Mann-Whitney, P = 0.028). CONCLUSIONS: Dyslipidemia and BMI ≥30 were associated with aPL Abs and therefore, the correction of BMI and lipid status might be beneficial in reduction or elimination of predisposing factors that might trigger thrombotic events in otherwise healthy middle-aged subjects. Larger national study is necessary to confirm our findings. |
format | Online Article Text |
id | pubmed-9618332 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Society of Medical Biochemists of Serbia, Belgrade |
record_format | MEDLINE/PubMed |
spelling | pubmed-96183322022-11-14 Antiphospholipid antibodies in healthy Serbian middle-aged subjects: Preliminary data Bećarević, Mirjana B. Jovičić, Snežana Ignjatović, Svetlana D. Mirković, Duško J Med Biochem Original Paper BACKGROUND: The investigation of the prevalence of the IgG and the IgM isotypes of anticardiolipin (aCL) and antib2glycoprotein I (ab2gpI) Abs in healthy Serbian middleaged subjects was the main goal of our study. In addition, we analyzed the potential associations of above-mentioned Abs with serum proteins and lipids/lipoproteins. METHODS: Forty healthy subjects were included in our study. Obesity (BMI 30 kg/m2) was present in 8/40 (20%) subjects. Titers of analyzed Abs were measured by ELISA. RESULTS: The prevalence of IgG and IgM ab2gpI Abs was 5% and 12.5%, respectively, while the prevalence of IgM aCL was 10%. The IgG ab2gpI Abs were significantly different between subjects with normal triglycerides levels and those with hypertriglyceridemia (Mann-Whitney, P = 0.014). The significant difference in hsCRP concentrations was observed between subjects with the increased levels of the IgM isotype of aCL Abs and those with normal IgM aCL values (Mann-Whitney, P = 0.028). CONCLUSIONS: Dyslipidemia and BMI ≥30 were associated with aPL Abs and therefore, the correction of BMI and lipid status might be beneficial in reduction or elimination of predisposing factors that might trigger thrombotic events in otherwise healthy middle-aged subjects. Larger national study is necessary to confirm our findings. Society of Medical Biochemists of Serbia, Belgrade 2022-10-15 2022-10-15 /pmc/articles/PMC9618332/ /pubmed/36381077 http://dx.doi.org/10.5937/jomb0-35642 Text en 2022 Mirjana B. Bećarević, Snežana Jovičić, Svetlana D. Ignjatović, Duško Mirković, published by CEON/CEES https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 License. |
spellingShingle | Original Paper Bećarević, Mirjana B. Jovičić, Snežana Ignjatović, Svetlana D. Mirković, Duško Antiphospholipid antibodies in healthy Serbian middle-aged subjects: Preliminary data |
title | Antiphospholipid antibodies in healthy Serbian middle-aged subjects: Preliminary data |
title_full | Antiphospholipid antibodies in healthy Serbian middle-aged subjects: Preliminary data |
title_fullStr | Antiphospholipid antibodies in healthy Serbian middle-aged subjects: Preliminary data |
title_full_unstemmed | Antiphospholipid antibodies in healthy Serbian middle-aged subjects: Preliminary data |
title_short | Antiphospholipid antibodies in healthy Serbian middle-aged subjects: Preliminary data |
title_sort | antiphospholipid antibodies in healthy serbian middle-aged subjects: preliminary data |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618332/ https://www.ncbi.nlm.nih.gov/pubmed/36381077 http://dx.doi.org/10.5937/jomb0-35642 |
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