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Evaluation of amino acid profile in serum of patients with Covid-19 for providing a new treatment strategy

BACKGROUND: Amino acids have an important role in metabolism and may affect COVID-19-related outcomes. In our study, the amino acid serum level of hospitalized COVID19 patients was evaluated to determine a new treatment strategy. METHODS: The amino acid profile covering 43 amino acids in 68 subjects...

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Autores principales: Ozturk, Ali, Bayraktar, Nihayet, Bayraktar, Mustafa, Ibrahim, Bashar, Bozok, Taylan, Resat, Ceylan Mehmet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Medical Biochemists of Serbia, Belgrade 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618340/
https://www.ncbi.nlm.nih.gov/pubmed/36381071
http://dx.doi.org/10.5937/jomb0-37514
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author Ozturk, Ali
Bayraktar, Nihayet
Bayraktar, Mustafa
Ibrahim, Bashar
Bozok, Taylan
Resat, Ceylan Mehmet
author_facet Ozturk, Ali
Bayraktar, Nihayet
Bayraktar, Mustafa
Ibrahim, Bashar
Bozok, Taylan
Resat, Ceylan Mehmet
author_sort Ozturk, Ali
collection PubMed
description BACKGROUND: Amino acids have an important role in metabolism and may affect COVID-19-related outcomes. In our study, the amino acid serum level of hospitalized COVID19 patients was evaluated to determine a new treatment strategy. METHODS: The amino acid profile covering 43 amino acids in 68 subjects, comprising 30 (14 men and 16 women) controls and 38 (16 men and 22 women) COVID-19 patients, were examined. The amino acid profiles of the participants were screened by LC-MS/MS. RESULTS: Compared with the control group, serum levels of 27 amino acids increased in the patient group. Alpha-aminopimelic acid, sarcosine, and hydroxyproline amino acids were considerably higher in the control group than in the patient group (p<0.0001). There was no notable difference among control group and the case group for 13 amino acids (p≥0.05). A significant positive correlation was seen among the control and the patient groups in the mean amino acid values (r=0.937; p<0.0001). CONCLUSIONS: These results postulated a clear picture on the serum levels of amino acid in the COVID-19 patients. Serum amino acids measured in hospitalized COVID-19 patients can explain the patient's metabolic status during the disease.
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spelling pubmed-96183402022-11-14 Evaluation of amino acid profile in serum of patients with Covid-19 for providing a new treatment strategy Ozturk, Ali Bayraktar, Nihayet Bayraktar, Mustafa Ibrahim, Bashar Bozok, Taylan Resat, Ceylan Mehmet J Med Biochem Original Paper BACKGROUND: Amino acids have an important role in metabolism and may affect COVID-19-related outcomes. In our study, the amino acid serum level of hospitalized COVID19 patients was evaluated to determine a new treatment strategy. METHODS: The amino acid profile covering 43 amino acids in 68 subjects, comprising 30 (14 men and 16 women) controls and 38 (16 men and 22 women) COVID-19 patients, were examined. The amino acid profiles of the participants were screened by LC-MS/MS. RESULTS: Compared with the control group, serum levels of 27 amino acids increased in the patient group. Alpha-aminopimelic acid, sarcosine, and hydroxyproline amino acids were considerably higher in the control group than in the patient group (p<0.0001). There was no notable difference among control group and the case group for 13 amino acids (p≥0.05). A significant positive correlation was seen among the control and the patient groups in the mean amino acid values (r=0.937; p<0.0001). CONCLUSIONS: These results postulated a clear picture on the serum levels of amino acid in the COVID-19 patients. Serum amino acids measured in hospitalized COVID-19 patients can explain the patient's metabolic status during the disease. Society of Medical Biochemists of Serbia, Belgrade 2022-10-15 2022-10-15 /pmc/articles/PMC9618340/ /pubmed/36381071 http://dx.doi.org/10.5937/jomb0-37514 Text en 2022 Ali Ozturk, Nihayet Bayraktar, Mustafa Bayraktar, Bashar Ibrahim, Taylan Bozok, Ceylan Mehmet Resat, published by CEON/CEES https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 License.
spellingShingle Original Paper
Ozturk, Ali
Bayraktar, Nihayet
Bayraktar, Mustafa
Ibrahim, Bashar
Bozok, Taylan
Resat, Ceylan Mehmet
Evaluation of amino acid profile in serum of patients with Covid-19 for providing a new treatment strategy
title Evaluation of amino acid profile in serum of patients with Covid-19 for providing a new treatment strategy
title_full Evaluation of amino acid profile in serum of patients with Covid-19 for providing a new treatment strategy
title_fullStr Evaluation of amino acid profile in serum of patients with Covid-19 for providing a new treatment strategy
title_full_unstemmed Evaluation of amino acid profile in serum of patients with Covid-19 for providing a new treatment strategy
title_short Evaluation of amino acid profile in serum of patients with Covid-19 for providing a new treatment strategy
title_sort evaluation of amino acid profile in serum of patients with covid-19 for providing a new treatment strategy
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618340/
https://www.ncbi.nlm.nih.gov/pubmed/36381071
http://dx.doi.org/10.5937/jomb0-37514
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