Cargando…

Reverse Cervical Lordosis Caused by Giant Vertebral Artery Aneurysm in von Recklinghausen Disease

Neurofibromatosis type 1 (NF1) is a variable penetrance autosomal dominant condition predominantly involving the peripheral nervous system. NF1 exhibits a wide spectrum of clinical patterns involving the skin, eye, brain, spinal cord, and, to a lesser extent, long bones and arteries. Arterial stenos...

Descripción completa

Detalles Bibliográficos
Autores principales: Saleh, Umaira, Ismail, Muhammad Ihfaz, Sapiai, Nur Asma, Loh, Kok Beng, Abd Wahab, Nasser, Abdullah, Jafri M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618347/
https://www.ncbi.nlm.nih.gov/pubmed/36340543
http://dx.doi.org/10.7759/cureus.29795
_version_ 1784821030467928064
author Saleh, Umaira
Ismail, Muhammad Ihfaz
Sapiai, Nur Asma
Loh, Kok Beng
Abd Wahab, Nasser
Abdullah, Jafri M
author_facet Saleh, Umaira
Ismail, Muhammad Ihfaz
Sapiai, Nur Asma
Loh, Kok Beng
Abd Wahab, Nasser
Abdullah, Jafri M
author_sort Saleh, Umaira
collection PubMed
description Neurofibromatosis type 1 (NF1) is a variable penetrance autosomal dominant condition predominantly involving the peripheral nervous system. NF1 exhibits a wide spectrum of clinical patterns involving the skin, eye, brain, spinal cord, and, to a lesser extent, long bones and arteries. Arterial stenosis or aneurysms have been variously studied, but the association with NF1 has not been firmly established. A 31-year-old gentleman with NF1 experienced progressive neck pain over a five-month period, associated with limited range of motion and dysphagia. Magnetic resonance imaging (MRI) of the cervical spine suggests paraspinal plexiform neurofibromas with excessive reverse cervical lordosis. Further workups revealed a large left vertebral artery fusiform aneurysm and a pseudoaneurysm. The patient made a full recovery following endovascular embolization. It is crucial to maintain a high index of suspicion for vascular malformations in patients with NF1. The pathogenesis of vascular manifestations in NF1 and options for therapeutic management were discussed.
format Online
Article
Text
id pubmed-9618347
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-96183472022-11-03 Reverse Cervical Lordosis Caused by Giant Vertebral Artery Aneurysm in von Recklinghausen Disease Saleh, Umaira Ismail, Muhammad Ihfaz Sapiai, Nur Asma Loh, Kok Beng Abd Wahab, Nasser Abdullah, Jafri M Cureus Radiology Neurofibromatosis type 1 (NF1) is a variable penetrance autosomal dominant condition predominantly involving the peripheral nervous system. NF1 exhibits a wide spectrum of clinical patterns involving the skin, eye, brain, spinal cord, and, to a lesser extent, long bones and arteries. Arterial stenosis or aneurysms have been variously studied, but the association with NF1 has not been firmly established. A 31-year-old gentleman with NF1 experienced progressive neck pain over a five-month period, associated with limited range of motion and dysphagia. Magnetic resonance imaging (MRI) of the cervical spine suggests paraspinal plexiform neurofibromas with excessive reverse cervical lordosis. Further workups revealed a large left vertebral artery fusiform aneurysm and a pseudoaneurysm. The patient made a full recovery following endovascular embolization. It is crucial to maintain a high index of suspicion for vascular malformations in patients with NF1. The pathogenesis of vascular manifestations in NF1 and options for therapeutic management were discussed. Cureus 2022-09-30 /pmc/articles/PMC9618347/ /pubmed/36340543 http://dx.doi.org/10.7759/cureus.29795 Text en Copyright © 2022, Saleh et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Radiology
Saleh, Umaira
Ismail, Muhammad Ihfaz
Sapiai, Nur Asma
Loh, Kok Beng
Abd Wahab, Nasser
Abdullah, Jafri M
Reverse Cervical Lordosis Caused by Giant Vertebral Artery Aneurysm in von Recklinghausen Disease
title Reverse Cervical Lordosis Caused by Giant Vertebral Artery Aneurysm in von Recklinghausen Disease
title_full Reverse Cervical Lordosis Caused by Giant Vertebral Artery Aneurysm in von Recklinghausen Disease
title_fullStr Reverse Cervical Lordosis Caused by Giant Vertebral Artery Aneurysm in von Recklinghausen Disease
title_full_unstemmed Reverse Cervical Lordosis Caused by Giant Vertebral Artery Aneurysm in von Recklinghausen Disease
title_short Reverse Cervical Lordosis Caused by Giant Vertebral Artery Aneurysm in von Recklinghausen Disease
title_sort reverse cervical lordosis caused by giant vertebral artery aneurysm in von recklinghausen disease
topic Radiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618347/
https://www.ncbi.nlm.nih.gov/pubmed/36340543
http://dx.doi.org/10.7759/cureus.29795
work_keys_str_mv AT salehumaira reversecervicallordosiscausedbygiantvertebralarteryaneurysminvonrecklinghausendisease
AT ismailmuhammadihfaz reversecervicallordosiscausedbygiantvertebralarteryaneurysminvonrecklinghausendisease
AT sapiainurasma reversecervicallordosiscausedbygiantvertebralarteryaneurysminvonrecklinghausendisease
AT lohkokbeng reversecervicallordosiscausedbygiantvertebralarteryaneurysminvonrecklinghausendisease
AT abdwahabnasser reversecervicallordosiscausedbygiantvertebralarteryaneurysminvonrecklinghausendisease
AT abdullahjafrim reversecervicallordosiscausedbygiantvertebralarteryaneurysminvonrecklinghausendisease