Nrf2 induces malignant transformation of hepatic progenitor cells by inducing β-catenin expression

The Nrf2 signaling pathway prevents cancer initiation, but genetic mutations that activate this pathway are found in various types of cancer. The molecular mechanisms underlying this Janus-headed character are still not understood. Here, we show that sustained Nrf2 activation induces proliferation a...

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Detalles Bibliográficos
Autores principales: Fragoulis, Athanassios, Schenkel, Julia, Schröder, Nicole, Brandt, Elisa Fabiana, Weiand, Mathias, Neu, Tabita, Ramadori, Pierluigi, Caspers, Tim, Kant, Sebastian, Pufe, Thomas, Mohs, Antje, Trautwein, Christian, Longerich, Thomas, Streetz, Konrad Ludwig, Wruck, Christoph Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Articles from the Special Issue on Redox Modulation of Cancer Heterogeneity, Therapeutic Resistance and Immunotherapy Efficacy; Edited by Dr. Anita Hjelmeland
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618468/
https://www.ncbi.nlm.nih.gov/pubmed/36209041
http://dx.doi.org/10.1016/j.redox.2022.102453

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