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High initial FSH dosage reduces the number of available cleavage-stage embryos in a GnRH-antagonist protocol: Real-world data of 8,772 IVF cycles from China

To evaluate the relationship between the initial follicle stimulating hormone (FSH) dose and the number of available cleavage-stage embryos in in vitro fertilization (IVF) cycles.We included 8772 fresh IVF cycles using a GnRH antagonist protocol at the Genetic and Reproductive Institution of Chongqi...

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Autores principales: Luo, Xiu, Pei, Li, He, Yao, Li, Fujie, Han, Wei, Xiong, Shun, Han, Shubiao, Li, Jingyu, Zhang, Xiaodong, Huang, Guoning, Ye, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618590/
https://www.ncbi.nlm.nih.gov/pubmed/36325448
http://dx.doi.org/10.3389/fendo.2022.986438
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author Luo, Xiu
Pei, Li
He, Yao
Li, Fujie
Han, Wei
Xiong, Shun
Han, Shubiao
Li, Jingyu
Zhang, Xiaodong
Huang, Guoning
Ye, Hong
author_facet Luo, Xiu
Pei, Li
He, Yao
Li, Fujie
Han, Wei
Xiong, Shun
Han, Shubiao
Li, Jingyu
Zhang, Xiaodong
Huang, Guoning
Ye, Hong
author_sort Luo, Xiu
collection PubMed
description To evaluate the relationship between the initial follicle stimulating hormone (FSH) dose and the number of available cleavage-stage embryos in in vitro fertilization (IVF) cycles.We included 8772 fresh IVF cycles using a GnRH antagonist protocol at the Genetic and Reproductive Institution of Chongqing, P. R. China, from January 2016 to June 2021.Univariate linear regression was used to evaluate the associations between the initial FSH dosage (≤ 150, 187.5–200, 225, 250, or 300 IU) with the number of available cleavage-stage embryos on day 3. A two-factor linear regression model was applied to calculate the threshold effect of the initial FSH dosage on the number of available cleavage-stage embryos based on a smoothing plot. The initial FSH dose was negatively correlated with the number of available cleavage-stage embryos, independent of female age, body mass index, infertility factors, duration of infertility, anti-Müllerian hormone and basal FSH levels, antral follicle count and the proportions of patients with poor ovarian response or polycystic ovarian syndrome. Using a two-factor linear regression model, we calculated the inflection point to be 200 IU of FSH. The relationship between the initial FSH dose and the number of available cleavage-stage embryos was nonlinear. The initial FSH dose was negatively associated with the number of available cleavage-stage embryos when the initial FSH dose was > 200 IU. Therefore, clinicians should try to avoid unnecessarily increasing the initial FSH dose.
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spelling pubmed-96185902022-11-01 High initial FSH dosage reduces the number of available cleavage-stage embryos in a GnRH-antagonist protocol: Real-world data of 8,772 IVF cycles from China Luo, Xiu Pei, Li He, Yao Li, Fujie Han, Wei Xiong, Shun Han, Shubiao Li, Jingyu Zhang, Xiaodong Huang, Guoning Ye, Hong Front Endocrinol (Lausanne) Endocrinology To evaluate the relationship between the initial follicle stimulating hormone (FSH) dose and the number of available cleavage-stage embryos in in vitro fertilization (IVF) cycles.We included 8772 fresh IVF cycles using a GnRH antagonist protocol at the Genetic and Reproductive Institution of Chongqing, P. R. China, from January 2016 to June 2021.Univariate linear regression was used to evaluate the associations between the initial FSH dosage (≤ 150, 187.5–200, 225, 250, or 300 IU) with the number of available cleavage-stage embryos on day 3. A two-factor linear regression model was applied to calculate the threshold effect of the initial FSH dosage on the number of available cleavage-stage embryos based on a smoothing plot. The initial FSH dose was negatively correlated with the number of available cleavage-stage embryos, independent of female age, body mass index, infertility factors, duration of infertility, anti-Müllerian hormone and basal FSH levels, antral follicle count and the proportions of patients with poor ovarian response or polycystic ovarian syndrome. Using a two-factor linear regression model, we calculated the inflection point to be 200 IU of FSH. The relationship between the initial FSH dose and the number of available cleavage-stage embryos was nonlinear. The initial FSH dose was negatively associated with the number of available cleavage-stage embryos when the initial FSH dose was > 200 IU. Therefore, clinicians should try to avoid unnecessarily increasing the initial FSH dose. Frontiers Media S.A. 2022-10-17 /pmc/articles/PMC9618590/ /pubmed/36325448 http://dx.doi.org/10.3389/fendo.2022.986438 Text en Copyright © 2022 Luo, Pei, He, Li, Han, Xiong, Han, Li, Zhang, Huang and Ye https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Luo, Xiu
Pei, Li
He, Yao
Li, Fujie
Han, Wei
Xiong, Shun
Han, Shubiao
Li, Jingyu
Zhang, Xiaodong
Huang, Guoning
Ye, Hong
High initial FSH dosage reduces the number of available cleavage-stage embryos in a GnRH-antagonist protocol: Real-world data of 8,772 IVF cycles from China
title High initial FSH dosage reduces the number of available cleavage-stage embryos in a GnRH-antagonist protocol: Real-world data of 8,772 IVF cycles from China
title_full High initial FSH dosage reduces the number of available cleavage-stage embryos in a GnRH-antagonist protocol: Real-world data of 8,772 IVF cycles from China
title_fullStr High initial FSH dosage reduces the number of available cleavage-stage embryos in a GnRH-antagonist protocol: Real-world data of 8,772 IVF cycles from China
title_full_unstemmed High initial FSH dosage reduces the number of available cleavage-stage embryos in a GnRH-antagonist protocol: Real-world data of 8,772 IVF cycles from China
title_short High initial FSH dosage reduces the number of available cleavage-stage embryos in a GnRH-antagonist protocol: Real-world data of 8,772 IVF cycles from China
title_sort high initial fsh dosage reduces the number of available cleavage-stage embryos in a gnrh-antagonist protocol: real-world data of 8,772 ivf cycles from china
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618590/
https://www.ncbi.nlm.nih.gov/pubmed/36325448
http://dx.doi.org/10.3389/fendo.2022.986438
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