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Hippocampal atrophy in neurofunctional subfields in insomnia individuals
OBJECTIVE: The aim of this study was to investigate the pattern of volume changes in neurofunctional hippocampal subfields in patients with insomnia and their associations with risk of development of insomnia. METHODS: A total of 120 patients with insomnia (78 females, 42 males; mean age ± standard...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618598/ https://www.ncbi.nlm.nih.gov/pubmed/36324378 http://dx.doi.org/10.3389/fneur.2022.1014244 |
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author | Yang, Yang Liang, Wei Wang, Yongjun Peng, Dechang Gong, Liang Wang, Na Huang, Zhongjie Yang, Weikang |
author_facet | Yang, Yang Liang, Wei Wang, Yongjun Peng, Dechang Gong, Liang Wang, Na Huang, Zhongjie Yang, Weikang |
author_sort | Yang, Yang |
collection | PubMed |
description | OBJECTIVE: The aim of this study was to investigate the pattern of volume changes in neurofunctional hippocampal subfields in patients with insomnia and their associations with risk of development of insomnia. METHODS: A total of 120 patients with insomnia (78 females, 42 males; mean age ± standard deviation, 43.74 ± 13.02 years) and 120 good sleepers (67 females, 53 males; mean age, 42.69 ± 12.24 years) were recruited. The left hippocampus was segmented into anterior (L1), middle (L2), and posterior (L3) subregions. The right hippocampus was segmented into top anterior (R1), second top anterior (R2), middle (R3), posterior (R4), and last posterior (R5) subregions. Multivariate logistic regression was used to evaluate the associations of hippocampal volume (HV) of each subfield with the risk of the development of insomnia. Mediation analyses were performed to evaluate mediated associations among post-insomnia negative emotion, insomnia severity, and HV atrophy. A visual easy-to-deploy risk nomogram was used for individual prediction of risk of development of insomnia. RESULTS: Hippocampal volume atrophy was identified in the L1, R1, and R2 subregions. L1 and R2 volume atrophy each predisposed to an ~3-fold higher risk of insomnia (L1, odds ratio: 2.90, 95% confidence intervals: [1.24, 6.76], p = 0.014; R2, 2.72 [1.19, 6.20], p = 0.018). Anxiety fully mediates the causal path of insomnia severity leading to R1 volume atrophy with a positive effect. We developed a practical and visual competing risk-nomogram tool for individual prediction of insomnia risk, which stratifies individuals into different levels of insomnia risk with the highest prediction accuracy of 97.4% and an average C-statistic of 0.83. CONCLUSION: Hippocampal atrophy in specific neurofunctional subfields was not only found to be associated with insomnia but also a significant risk factor predicting development of insomnia. |
format | Online Article Text |
id | pubmed-9618598 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96185982022-11-01 Hippocampal atrophy in neurofunctional subfields in insomnia individuals Yang, Yang Liang, Wei Wang, Yongjun Peng, Dechang Gong, Liang Wang, Na Huang, Zhongjie Yang, Weikang Front Neurol Neurology OBJECTIVE: The aim of this study was to investigate the pattern of volume changes in neurofunctional hippocampal subfields in patients with insomnia and their associations with risk of development of insomnia. METHODS: A total of 120 patients with insomnia (78 females, 42 males; mean age ± standard deviation, 43.74 ± 13.02 years) and 120 good sleepers (67 females, 53 males; mean age, 42.69 ± 12.24 years) were recruited. The left hippocampus was segmented into anterior (L1), middle (L2), and posterior (L3) subregions. The right hippocampus was segmented into top anterior (R1), second top anterior (R2), middle (R3), posterior (R4), and last posterior (R5) subregions. Multivariate logistic regression was used to evaluate the associations of hippocampal volume (HV) of each subfield with the risk of the development of insomnia. Mediation analyses were performed to evaluate mediated associations among post-insomnia negative emotion, insomnia severity, and HV atrophy. A visual easy-to-deploy risk nomogram was used for individual prediction of risk of development of insomnia. RESULTS: Hippocampal volume atrophy was identified in the L1, R1, and R2 subregions. L1 and R2 volume atrophy each predisposed to an ~3-fold higher risk of insomnia (L1, odds ratio: 2.90, 95% confidence intervals: [1.24, 6.76], p = 0.014; R2, 2.72 [1.19, 6.20], p = 0.018). Anxiety fully mediates the causal path of insomnia severity leading to R1 volume atrophy with a positive effect. We developed a practical and visual competing risk-nomogram tool for individual prediction of insomnia risk, which stratifies individuals into different levels of insomnia risk with the highest prediction accuracy of 97.4% and an average C-statistic of 0.83. CONCLUSION: Hippocampal atrophy in specific neurofunctional subfields was not only found to be associated with insomnia but also a significant risk factor predicting development of insomnia. Frontiers Media S.A. 2022-10-17 /pmc/articles/PMC9618598/ /pubmed/36324378 http://dx.doi.org/10.3389/fneur.2022.1014244 Text en Copyright © 2022 Yang, Liang, Wang, Peng, Gong, Wang, Huang and Yang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Yang, Yang Liang, Wei Wang, Yongjun Peng, Dechang Gong, Liang Wang, Na Huang, Zhongjie Yang, Weikang Hippocampal atrophy in neurofunctional subfields in insomnia individuals |
title | Hippocampal atrophy in neurofunctional subfields in insomnia individuals |
title_full | Hippocampal atrophy in neurofunctional subfields in insomnia individuals |
title_fullStr | Hippocampal atrophy in neurofunctional subfields in insomnia individuals |
title_full_unstemmed | Hippocampal atrophy in neurofunctional subfields in insomnia individuals |
title_short | Hippocampal atrophy in neurofunctional subfields in insomnia individuals |
title_sort | hippocampal atrophy in neurofunctional subfields in insomnia individuals |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618598/ https://www.ncbi.nlm.nih.gov/pubmed/36324378 http://dx.doi.org/10.3389/fneur.2022.1014244 |
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