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Diagnostic value of RDW for the prediction of mortality in adult sepsis patients: A systematic review and meta-analysis

BACKGROUND: Red blood cell distribution width (RDW) is a common biomarker of bacterial infections, and it can be easily obtained from a routine blood test. We investigate the diagnostic value of RDW for the prediction of mortality in adult sepsis patients through a review and meta-analysis. We regis...

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Autores principales: Wu, Hongsheng, Liao, Biling, Cao, Tiansheng, Ji, Tengfei, Huang, Jianbin, Ma, Keqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618606/
https://www.ncbi.nlm.nih.gov/pubmed/36325342
http://dx.doi.org/10.3389/fimmu.2022.997853
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author Wu, Hongsheng
Liao, Biling
Cao, Tiansheng
Ji, Tengfei
Huang, Jianbin
Ma, Keqiang
author_facet Wu, Hongsheng
Liao, Biling
Cao, Tiansheng
Ji, Tengfei
Huang, Jianbin
Ma, Keqiang
author_sort Wu, Hongsheng
collection PubMed
description BACKGROUND: Red blood cell distribution width (RDW) is a common biomarker of bacterial infections, and it can be easily obtained from a routine blood test. We investigate the diagnostic value of RDW for the prediction of mortality in adult sepsis patients through a review and meta-analysis. We registered this review in PROSPERO (Registration Number: CRD42022357712), and the details of the registration are included in Appendix 1. METHODS: We searched PubMed, Cochrane Library, Springer, and Embase between Jan. 1, 2000, and May 30, 2022, for primary studies about this research. We collected articles that investigated RDW for varying degrees of sepsis patients—those who suffered from sepsis, severe sepsis, or sepsis shock. Studies of healthy people and sepsis of children and neonates were excluded from our research. The definition of study characteristics and data extraction were finished by two independent researchers and discrepancies resolved by consensus. The combined sensitivities and specificities were calculated by meta-analysis using STATA14.0. The sensitivity of the included studies was analyzed by excluding studies that had potential heterogeneity. A summary operating characteristic curve was made to evaluate the diagnostic value for the prediction of mortality in adult sepsis patients. The Fagan test was used to explore likelihood ratios and posttest probabilities. Finally, we investigated the source of heterogeneity using meta-regression. RESULTS: Twenty-four studies, including 40,763 cases altogether, were included in this analysis. Bivariate analysis indicated a combined sensitivity of 0.81 (95% CI 0.73–0.86) and specificity of 0.65 (95% CI 0.54–0.75). The area under the summary receiver operating characteristic curve was 0.81 (95% CI 0.77–0.84). Substantial heterogeneity resided in the studies (I(2 =) 96.68, 95% CI 95.95–97.4). Meta-regression showed that the reference description, prospective design, and blinded interpretation of the included studies could be responsible for the heterogeneity. CONCLUSIONS: RWD is an available and valuable biomarker for prediction of mortality in adult sepsis patients. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022357712.
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spelling pubmed-96186062022-11-01 Diagnostic value of RDW for the prediction of mortality in adult sepsis patients: A systematic review and meta-analysis Wu, Hongsheng Liao, Biling Cao, Tiansheng Ji, Tengfei Huang, Jianbin Ma, Keqiang Front Immunol Immunology BACKGROUND: Red blood cell distribution width (RDW) is a common biomarker of bacterial infections, and it can be easily obtained from a routine blood test. We investigate the diagnostic value of RDW for the prediction of mortality in adult sepsis patients through a review and meta-analysis. We registered this review in PROSPERO (Registration Number: CRD42022357712), and the details of the registration are included in Appendix 1. METHODS: We searched PubMed, Cochrane Library, Springer, and Embase between Jan. 1, 2000, and May 30, 2022, for primary studies about this research. We collected articles that investigated RDW for varying degrees of sepsis patients—those who suffered from sepsis, severe sepsis, or sepsis shock. Studies of healthy people and sepsis of children and neonates were excluded from our research. The definition of study characteristics and data extraction were finished by two independent researchers and discrepancies resolved by consensus. The combined sensitivities and specificities were calculated by meta-analysis using STATA14.0. The sensitivity of the included studies was analyzed by excluding studies that had potential heterogeneity. A summary operating characteristic curve was made to evaluate the diagnostic value for the prediction of mortality in adult sepsis patients. The Fagan test was used to explore likelihood ratios and posttest probabilities. Finally, we investigated the source of heterogeneity using meta-regression. RESULTS: Twenty-four studies, including 40,763 cases altogether, were included in this analysis. Bivariate analysis indicated a combined sensitivity of 0.81 (95% CI 0.73–0.86) and specificity of 0.65 (95% CI 0.54–0.75). The area under the summary receiver operating characteristic curve was 0.81 (95% CI 0.77–0.84). Substantial heterogeneity resided in the studies (I(2 =) 96.68, 95% CI 95.95–97.4). Meta-regression showed that the reference description, prospective design, and blinded interpretation of the included studies could be responsible for the heterogeneity. CONCLUSIONS: RWD is an available and valuable biomarker for prediction of mortality in adult sepsis patients. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022357712. Frontiers Media S.A. 2022-10-17 /pmc/articles/PMC9618606/ /pubmed/36325342 http://dx.doi.org/10.3389/fimmu.2022.997853 Text en Copyright © 2022 Wu, Liao, Cao, Ji, Huang and Ma https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Wu, Hongsheng
Liao, Biling
Cao, Tiansheng
Ji, Tengfei
Huang, Jianbin
Ma, Keqiang
Diagnostic value of RDW for the prediction of mortality in adult sepsis patients: A systematic review and meta-analysis
title Diagnostic value of RDW for the prediction of mortality in adult sepsis patients: A systematic review and meta-analysis
title_full Diagnostic value of RDW for the prediction of mortality in adult sepsis patients: A systematic review and meta-analysis
title_fullStr Diagnostic value of RDW for the prediction of mortality in adult sepsis patients: A systematic review and meta-analysis
title_full_unstemmed Diagnostic value of RDW for the prediction of mortality in adult sepsis patients: A systematic review and meta-analysis
title_short Diagnostic value of RDW for the prediction of mortality in adult sepsis patients: A systematic review and meta-analysis
title_sort diagnostic value of rdw for the prediction of mortality in adult sepsis patients: a systematic review and meta-analysis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618606/
https://www.ncbi.nlm.nih.gov/pubmed/36325342
http://dx.doi.org/10.3389/fimmu.2022.997853
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