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Progress in the application of body fluid and tissue level mRNAs-non-coding RNAs for the early diagnosis and prognostic evaluation of systemic lupus erythematosus

The diagnosis and differential classification of systemic lupus erythematosus (SLE) is difficult, especially in patients with early-onset SLE who are susceptible to systemic multi-organ damage and serious complications and have difficulties in individualized treatment. At present, diagnosis is based...

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Autores principales: Liang, Jiabin, Xie, Fangmei, Feng, Jie, Huang, Chen, Shen, Jian, Han, Zeping, Luo, Wenfeng, He, Jinhua, Chen, Hanwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618628/
https://www.ncbi.nlm.nih.gov/pubmed/36325322
http://dx.doi.org/10.3389/fimmu.2022.1020891
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author Liang, Jiabin
Xie, Fangmei
Feng, Jie
Huang, Chen
Shen, Jian
Han, Zeping
Luo, Wenfeng
He, Jinhua
Chen, Hanwei
author_facet Liang, Jiabin
Xie, Fangmei
Feng, Jie
Huang, Chen
Shen, Jian
Han, Zeping
Luo, Wenfeng
He, Jinhua
Chen, Hanwei
author_sort Liang, Jiabin
collection PubMed
description The diagnosis and differential classification of systemic lupus erythematosus (SLE) is difficult, especially in patients with early-onset SLE who are susceptible to systemic multi-organ damage and serious complications and have difficulties in individualized treatment. At present, diagnosis is based mainly on clinical manifestations and the detection of serological antinuclear antibodies. The pathogenesis of SLE involves multiple factors, is clinically heterogeneous, and lacks specific biomarkers. Therefore, it is necessary to identify new biomarkers for the diagnosis and subtype classification of SLE. Non-coding RNAs (ncRNAs) are composed of microRNAs, long non-coding RNAs, small nucleolar RNAs, circular RNAs, and transfer RNAs. They play an important role in the occurrence and development of diseases and are used widely in the early diagnosis and prognosis of autoimmune diseases. In this review, we focus on the research progress in the diagnosis and prognostic assessment of SLE using humoral to tissue level ncRNAs.
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spelling pubmed-96186282022-11-01 Progress in the application of body fluid and tissue level mRNAs-non-coding RNAs for the early diagnosis and prognostic evaluation of systemic lupus erythematosus Liang, Jiabin Xie, Fangmei Feng, Jie Huang, Chen Shen, Jian Han, Zeping Luo, Wenfeng He, Jinhua Chen, Hanwei Front Immunol Immunology The diagnosis and differential classification of systemic lupus erythematosus (SLE) is difficult, especially in patients with early-onset SLE who are susceptible to systemic multi-organ damage and serious complications and have difficulties in individualized treatment. At present, diagnosis is based mainly on clinical manifestations and the detection of serological antinuclear antibodies. The pathogenesis of SLE involves multiple factors, is clinically heterogeneous, and lacks specific biomarkers. Therefore, it is necessary to identify new biomarkers for the diagnosis and subtype classification of SLE. Non-coding RNAs (ncRNAs) are composed of microRNAs, long non-coding RNAs, small nucleolar RNAs, circular RNAs, and transfer RNAs. They play an important role in the occurrence and development of diseases and are used widely in the early diagnosis and prognosis of autoimmune diseases. In this review, we focus on the research progress in the diagnosis and prognostic assessment of SLE using humoral to tissue level ncRNAs. Frontiers Media S.A. 2022-10-17 /pmc/articles/PMC9618628/ /pubmed/36325322 http://dx.doi.org/10.3389/fimmu.2022.1020891 Text en Copyright © 2022 Liang, Xie, Feng, Huang, Shen, Han, Luo, He and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Liang, Jiabin
Xie, Fangmei
Feng, Jie
Huang, Chen
Shen, Jian
Han, Zeping
Luo, Wenfeng
He, Jinhua
Chen, Hanwei
Progress in the application of body fluid and tissue level mRNAs-non-coding RNAs for the early diagnosis and prognostic evaluation of systemic lupus erythematosus
title Progress in the application of body fluid and tissue level mRNAs-non-coding RNAs for the early diagnosis and prognostic evaluation of systemic lupus erythematosus
title_full Progress in the application of body fluid and tissue level mRNAs-non-coding RNAs for the early diagnosis and prognostic evaluation of systemic lupus erythematosus
title_fullStr Progress in the application of body fluid and tissue level mRNAs-non-coding RNAs for the early diagnosis and prognostic evaluation of systemic lupus erythematosus
title_full_unstemmed Progress in the application of body fluid and tissue level mRNAs-non-coding RNAs for the early diagnosis and prognostic evaluation of systemic lupus erythematosus
title_short Progress in the application of body fluid and tissue level mRNAs-non-coding RNAs for the early diagnosis and prognostic evaluation of systemic lupus erythematosus
title_sort progress in the application of body fluid and tissue level mrnas-non-coding rnas for the early diagnosis and prognostic evaluation of systemic lupus erythematosus
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618628/
https://www.ncbi.nlm.nih.gov/pubmed/36325322
http://dx.doi.org/10.3389/fimmu.2022.1020891
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