Microneedle-mediated drug delivery for cutaneous diseases

Microneedles have garnered significant interest as transdermal drug delivery route owing to the advantages of nonselective loading capacity, minimal invasiveness, simple operation, and good biocompatibility. A number of therapeutics can be loaded into microneedles, including hydrophilic and hydropho...

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Autores principales: Chen, Jian, Ren, Hui, Zhou, Pan, Zheng, Shuai, Du, Bin, Liu, Xiaowen, Xiao, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618658/
https://www.ncbi.nlm.nih.gov/pubmed/36324904
http://dx.doi.org/10.3389/fbioe.2022.1032041
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author Chen, Jian
Ren, Hui
Zhou, Pan
Zheng, Shuai
Du, Bin
Liu, Xiaowen
Xiao, Fei
author_facet Chen, Jian
Ren, Hui
Zhou, Pan
Zheng, Shuai
Du, Bin
Liu, Xiaowen
Xiao, Fei
author_sort Chen, Jian
collection PubMed
description Microneedles have garnered significant interest as transdermal drug delivery route owing to the advantages of nonselective loading capacity, minimal invasiveness, simple operation, and good biocompatibility. A number of therapeutics can be loaded into microneedles, including hydrophilic and hydrophobic small molecular drugs, and macromolecular drugs (proteins, mRNA, peptides, vaccines) for treatment of miscellaneous diseases. Microneedles feature with special benefits for cutaneous diseases owing to the direct transdermal delivery of therapeutics to the skin. This review mainly introduces microneedles fabricated with different technologies and transdermal delivery of various therapeutics for cutaneous diseases, such as psoriasis, atopic dermatitis, skin and soft tissue infection, superficial tumors, axillary hyperhidrosis, and plantar warts.
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spelling pubmed-96186582022-11-01 Microneedle-mediated drug delivery for cutaneous diseases Chen, Jian Ren, Hui Zhou, Pan Zheng, Shuai Du, Bin Liu, Xiaowen Xiao, Fei Front Bioeng Biotechnol Bioengineering and Biotechnology Microneedles have garnered significant interest as transdermal drug delivery route owing to the advantages of nonselective loading capacity, minimal invasiveness, simple operation, and good biocompatibility. A number of therapeutics can be loaded into microneedles, including hydrophilic and hydrophobic small molecular drugs, and macromolecular drugs (proteins, mRNA, peptides, vaccines) for treatment of miscellaneous diseases. Microneedles feature with special benefits for cutaneous diseases owing to the direct transdermal delivery of therapeutics to the skin. This review mainly introduces microneedles fabricated with different technologies and transdermal delivery of various therapeutics for cutaneous diseases, such as psoriasis, atopic dermatitis, skin and soft tissue infection, superficial tumors, axillary hyperhidrosis, and plantar warts. Frontiers Media S.A. 2022-10-17 /pmc/articles/PMC9618658/ /pubmed/36324904 http://dx.doi.org/10.3389/fbioe.2022.1032041 Text en Copyright © 2022 Chen, Ren, Zhou, Zheng, Du, Liu and Xiao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Chen, Jian
Ren, Hui
Zhou, Pan
Zheng, Shuai
Du, Bin
Liu, Xiaowen
Xiao, Fei
Microneedle-mediated drug delivery for cutaneous diseases
title Microneedle-mediated drug delivery for cutaneous diseases
title_full Microneedle-mediated drug delivery for cutaneous diseases
title_fullStr Microneedle-mediated drug delivery for cutaneous diseases
title_full_unstemmed Microneedle-mediated drug delivery for cutaneous diseases
title_short Microneedle-mediated drug delivery for cutaneous diseases
title_sort microneedle-mediated drug delivery for cutaneous diseases
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618658/
https://www.ncbi.nlm.nih.gov/pubmed/36324904
http://dx.doi.org/10.3389/fbioe.2022.1032041
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