Cargando…

MGUS and clonal hematopoiesis show unrelated clinical and biological trajectories in an older population cohort

Monoclonal gammopathy of undetermined significance (MGUS) and clonal hematopoiesis (CH) are 2 preclinical clonal expansions of hematopoietic cells whose prevalence rises with age, reaching almost 10% in people of aged 70 years and older. The increased risk of myeloid malignancies in patients with my...

Descripción completa

Detalles Bibliográficos
Autores principales:	Da Vià, Matteo Claudio, Lionetti, Marta, Marella, Alessio, Matera, Antonio, Travaglino, Erica, Signaroldi, Elena, Galbussera, Alessia Antonella, Lucca, Ugo, Mandelli, Sara, Riva, Emma, Tettamanti, Mauro, Pettine, Loredana, Pompa, Alessandra, Baldini, Luca, Neri, Antonino, Della Porta, Matteo Giovanni, Bolli, Niccolò
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society of Hematology 2022
Materias:	Stimulus Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618778/ https://www.ncbi.nlm.nih.gov/pubmed/35390146 http://dx.doi.org/10.1182/bloodadvances.2021006498

Ejemplares similares

Prevalence of heavy chain MGUS by race and family history risk groups using a high-sensitivity screening method
por: Vachon, Celine M., et al.
Publicado: (2022)

Clonal hematopoiesis is associated with increased risk of progression of asymptomatic Waldenström macroglobulinemia
por: Tahri, Sabrin, et al.
Publicado: (2022)

Evaluation of clonal hematopoiesis in pediatric ADA-SCID gene therapy participants
por: White, Shanna L., et al.
Publicado: (2022)

Functional Impact of Genomic Complexity on the Transcriptome of Multiple Myeloma
por: Ziccheddu, Bachisio, et al.
Publicado: (2021)

Mild anemia and 11- to 15-year mortality risk in young-old and old-old: Results from two population-based cohort studies
por: Galbussera, Alessia A., et al.
Publicado: (2021)

Dissemination of extreme levels of extracellular vesicles: tissue factor activity in patients with severe COVID-19
por: Guervilly, Christophe, et al.
Publicado: (2021)

The SARS-CoV-2 receptor-binding domain preferentially recognizes blood group A
por: Wu, Shang-Chuen, et al.
Publicado: (2021)

Impact of sickle cell trait on morbidity and mortality from SARS-CoV-2 infection
por: Merz, Lauren E., et al.
Publicado: (2021)

IL-6 antagonists to replace systemic corticosteroids as the preferred anti-inflammatory therapy in patients with COVID-19?
por: Kow, Chia Siang, et al.
Publicado: (2022)

COVID-19 and CAR T cells: a report on current challenges and future directions from the EPICOVIDEHA survey by EHA-IDWP
por: Busca, Alessandro, et al.
Publicado: (2022)

A novel class of ZNF384 aberrations in acute leukemia
por: Zaliova, Marketa, et al.
Publicado: (2021)

Anti-cysteine/spacer antibodies that open ADAMTS13 are a common feature in iTTP
por: De Waele, Laure, et al.
Publicado: (2021)

Rational biomarker development for the early and minimally invasive monitoring of AML
por: Abdelhamed, Sherif, et al.
Publicado: (2021)

TET2 mutations as a part of DNA dioxygenase deficiency in myelodysplastic syndromes
por: Gurnari, Carmelo, et al.
Publicado: (2022)

JMML tumor cells disrupt normal hematopoietic stem cells by imposing inflammatory stress through overproduction of IL-1β
por: Yan, Yuhan, et al.
Publicado: (2022)

Worse outcome and distinct mutational pattern in follicular lymphoma with anti-HBc positivity
por: Fernández-Rodríguez, Concepción, et al.
Publicado: (2022)

Coevolving JAK2(V617F+)relapsed AML and donor T cells with PD-1 blockade after stem cell transplantation: an index case
por: Penter, Livius, et al.
Publicado: (2021)

Molecular diagnosis of T-cell lymphoma: a correlative study of PCR-based T-cell clonality assessment and targeted NGS
por: Syrykh, Charlotte, et al.
Publicado: (2021)

Single-cell polyfunctional proteomics of CD4 cells from patients with AML predicts responses to anti–PD-1–based therapy
por: Abbas, Hussein A., et al.
Publicado: (2021)

Clinical care pathway for the evaluation of patients with suspected VITT after ChAdOx1 nCoV-19 vaccination
por: Lee, Agnes Y. Y., et al.
Publicado: (2022)

RNA sequencing of chronic GVHD skin lesions defines shared and unique inflammatory pathways characterizing lichen planus and morphea
por: Zouali, Habib, et al.
Publicado: (2022)

Day 30 SUV(max) predicts progression in patients with lymphoma achieving PR/SD after CAR T-cell therapy
por: Al Zaki, Ajlan, et al.
Publicado: (2022)

Live imaging of platelets and neutrophils during antibody-mediated neurovascular thrombosis
por: Laroche, Audree, et al.
Publicado: (2022)

The CLL comorbidity index in a population-based cohort: a tool for clinical care and research
por: Rotbain, Emelie C., et al.
Publicado: (2022)

Convalescent plasma with a high level of virus-specific antibody effectively neutralizes SARS-CoV-2 variants of concern
por: Li, Maggie, et al.
Publicado: (2022)

Single-cell sequencing demonstrates complex resistance landscape in CLL and MCL treated with BTK and BCL2 inhibitors
por: Thompson, Ella R., et al.
Publicado: (2022)

CPX-351 induces remission in newly diagnosed pediatric secondary myeloid malignancies
por: Hu, Yixin, et al.
Publicado: (2022)

Toll-like receptor 4 selective inhibition in medullar microenvironment alters multiple myeloma cell growth
por: Lemaitre, Léa, et al.
Publicado: (2022)

Anti–IL-6 cytokine treatment has no impact on elevated hematocrit or splenomegaly in a polycythemia vera mouse model
por: Baldauf, Conny K., et al.
Publicado: (2022)

Genetic features and clinical outcomes of patients with isolated and comutated DDX41-mutated myeloid neoplasms
por: Alkhateeb, Hassan B., et al.
Publicado: (2022)

Multiple myeloma cells depend on the DDI2/NRF1-mediated proteasome stress response for survival
por: Chen, Tianzeng, et al.
Publicado: (2022)

VpreB surrogate light chain expression in B-lineage ALL: a report from the Children’s Oncology Group
por: Winter, Stuart S., et al.
Publicado: (2022)

Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia
por: Krosl, Jana, et al.
Publicado: (2022)

MCT1 is a predictive marker for lenalidomide maintenance therapy in multiple myeloma
por: Stroh, Jacob, et al.
Publicado: (2022)

Origins of bloodstream infections following fecal microbiota transplantation: a strain-level analysis
por: Eshel, Adi, et al.
Publicado: (2022)

Idiopathic purpura fulminans associated with anti-protein S antibodies in children: a multicenter case series and systematic review
por: Theron, Alexandre, et al.
Publicado: (2022)

Neutrophil cathepsin G proteolysis of protease-activated receptor 4 generates a novel, functional tethered ligand
por: Stoller, Michelle L., et al.
Publicado: (2022)

Identification of germline monoallelic mutations in IKZF2 in patients with immune dysregulation
por: Shahin, Tala, et al.
Publicado: (2022)

Modulating endothelial cells with EGFL7 to diminish aGVHD after allogeneic bone marrow transplantation in mice
por: Dorrance, Adrienne M., et al.
Publicado: (2022)

Humoral response to mRNA anti–COVID-19 vaccines BNT162b2 and mRNA-1273 in patients with chronic lymphocytic leukemia
por: Bagacean, Cristina, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_8h9keh850un5588u3ob4eetmc9