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Low-density lipoprotein receptor genotypes modify the sera metabolome of patients with homozygous familial hypercholesterolemia

Homozygous familial hypercholesterolemia (HoFH) is an extremely rare metabolism disorder usually caused by low-density lipoprotein receptor (LDLR) mutations. LDLR genotype is commonly known to determine blood concentrations of LDL cholesterol. However, effects of LDLR genotype on holistic metabolome...

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Detalles Bibliográficos
Autores principales:	Du, Zhiyong, Li, Fan, Li, Linyi, Wang, Yu, Li, Jianping, Yang, Ya, Jiang, Long, Wang, Luya, Qin, Yanwen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618791/ https://www.ncbi.nlm.nih.gov/pubmed/36325061 http://dx.doi.org/10.1016/j.isci.2022.105334

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