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Characteristics of cerebral blood flow in an Eastern sample of multiple sclerosis patients: A potential quantitative imaging marker associated with disease severity

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system that is rare in China. At present, there are no widespread quantitative imaging markers associated with disease severity in MS. Despite several previous studies reporting cerebral blood flow (CBF) changes in MS,...

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Autores principales: Zhou, Qinming, Zhang, Tianxiao, Meng, Huanyu, Shen, Dingding, Li, Yao, He, Lu, Gao, Yining, Zhang, Yizongheng, Huang, Xinyun, Meng, Hongping, Li, Biao, Zhang, Min, Chen, Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618793/
https://www.ncbi.nlm.nih.gov/pubmed/36325320
http://dx.doi.org/10.3389/fimmu.2022.1025908
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author Zhou, Qinming
Zhang, Tianxiao
Meng, Huanyu
Shen, Dingding
Li, Yao
He, Lu
Gao, Yining
Zhang, Yizongheng
Huang, Xinyun
Meng, Hongping
Li, Biao
Zhang, Min
Chen, Sheng
author_facet Zhou, Qinming
Zhang, Tianxiao
Meng, Huanyu
Shen, Dingding
Li, Yao
He, Lu
Gao, Yining
Zhang, Yizongheng
Huang, Xinyun
Meng, Hongping
Li, Biao
Zhang, Min
Chen, Sheng
author_sort Zhou, Qinming
collection PubMed
description Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system that is rare in China. At present, there are no widespread quantitative imaging markers associated with disease severity in MS. Despite several previous studies reporting cerebral blood flow (CBF) changes in MS, no consensus has been reached. In this study, we enrolled 30 Eastern MS patients to investigate CBF changes in different brain regions using the arterial spin labeling technique and their relationship with disease severity. The average CBF in MS patients were higher than those in health controls in various brain regions except cerebellum. The results indicated that MS patients with strongly increased CBF showed worse disease severity, including higher Expanded Disability Status Scale (EDSS) scores and serum neurofilament light chain (sNfL) values than those with mildly increased CBF in the parietal lobes, temporal lobes, basal ganglia, and damaged white matter (DWM). From another perspective, MS patients with worse disease severity (higher EDSS score and sNfL values, longer disease duration) showed increased CBF in parietal lobes, temporal lobes, basal ganglia, normal-appearing white matter (NAWM), and DWM. Correlation analysis showed that there was a strong association among CBF, EDSS score and sNfL. MS patients with strongly increased CBF in various brain regions had more ratio in relapsing phase than patients with mildly increased CBF. And relapsing patients showed significantly higher CBF in some regions (temporal lobes, left basal ganglia, right NAWM) compared to remitting patients. In addition, MS patients with cognitive impairment had higher CBF than those without cognitive impairment in the right parietal lobe and NAWM. However, there were no significant differences in CBF between MS patients with and without other neurologic dysfunctions (e.g., motor impairment, visual disturbance, sensory dysfunction). These findings expand our understanding of CBF in MS and imply that CBF could be a potential quantitative imaging marker associated with disease severity.
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spelling pubmed-96187932022-11-01 Characteristics of cerebral blood flow in an Eastern sample of multiple sclerosis patients: A potential quantitative imaging marker associated with disease severity Zhou, Qinming Zhang, Tianxiao Meng, Huanyu Shen, Dingding Li, Yao He, Lu Gao, Yining Zhang, Yizongheng Huang, Xinyun Meng, Hongping Li, Biao Zhang, Min Chen, Sheng Front Immunol Immunology Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system that is rare in China. At present, there are no widespread quantitative imaging markers associated with disease severity in MS. Despite several previous studies reporting cerebral blood flow (CBF) changes in MS, no consensus has been reached. In this study, we enrolled 30 Eastern MS patients to investigate CBF changes in different brain regions using the arterial spin labeling technique and their relationship with disease severity. The average CBF in MS patients were higher than those in health controls in various brain regions except cerebellum. The results indicated that MS patients with strongly increased CBF showed worse disease severity, including higher Expanded Disability Status Scale (EDSS) scores and serum neurofilament light chain (sNfL) values than those with mildly increased CBF in the parietal lobes, temporal lobes, basal ganglia, and damaged white matter (DWM). From another perspective, MS patients with worse disease severity (higher EDSS score and sNfL values, longer disease duration) showed increased CBF in parietal lobes, temporal lobes, basal ganglia, normal-appearing white matter (NAWM), and DWM. Correlation analysis showed that there was a strong association among CBF, EDSS score and sNfL. MS patients with strongly increased CBF in various brain regions had more ratio in relapsing phase than patients with mildly increased CBF. And relapsing patients showed significantly higher CBF in some regions (temporal lobes, left basal ganglia, right NAWM) compared to remitting patients. In addition, MS patients with cognitive impairment had higher CBF than those without cognitive impairment in the right parietal lobe and NAWM. However, there were no significant differences in CBF between MS patients with and without other neurologic dysfunctions (e.g., motor impairment, visual disturbance, sensory dysfunction). These findings expand our understanding of CBF in MS and imply that CBF could be a potential quantitative imaging marker associated with disease severity. Frontiers Media S.A. 2022-10-17 /pmc/articles/PMC9618793/ /pubmed/36325320 http://dx.doi.org/10.3389/fimmu.2022.1025908 Text en Copyright © 2022 Zhou, Zhang, Meng, Shen, Li, He, Gao, Zhang, Huang, Meng, Li, Zhang and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhou, Qinming
Zhang, Tianxiao
Meng, Huanyu
Shen, Dingding
Li, Yao
He, Lu
Gao, Yining
Zhang, Yizongheng
Huang, Xinyun
Meng, Hongping
Li, Biao
Zhang, Min
Chen, Sheng
Characteristics of cerebral blood flow in an Eastern sample of multiple sclerosis patients: A potential quantitative imaging marker associated with disease severity
title Characteristics of cerebral blood flow in an Eastern sample of multiple sclerosis patients: A potential quantitative imaging marker associated with disease severity
title_full Characteristics of cerebral blood flow in an Eastern sample of multiple sclerosis patients: A potential quantitative imaging marker associated with disease severity
title_fullStr Characteristics of cerebral blood flow in an Eastern sample of multiple sclerosis patients: A potential quantitative imaging marker associated with disease severity
title_full_unstemmed Characteristics of cerebral blood flow in an Eastern sample of multiple sclerosis patients: A potential quantitative imaging marker associated with disease severity
title_short Characteristics of cerebral blood flow in an Eastern sample of multiple sclerosis patients: A potential quantitative imaging marker associated with disease severity
title_sort characteristics of cerebral blood flow in an eastern sample of multiple sclerosis patients: a potential quantitative imaging marker associated with disease severity
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618793/
https://www.ncbi.nlm.nih.gov/pubmed/36325320
http://dx.doi.org/10.3389/fimmu.2022.1025908
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