Cargando…

CXCR1 and its downstream NF-κB inflammation signaling pathway as a key target of Guanxinning injection for myocardial ischemia/reperfusion injury

Guanxinning Injection (GXNI) is used clinically to treat cardiac injury, but its active components and mode of action remains unclear. Therefore, a myocardial ischemia/reperfusion injury (MIRI) model-based integrated strategy including function evaluation, RNA-seq analysis, molecular docking, and ce...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xiao, Guangxu, Liu, Jiaxu, Wang, Huanyi, He, Shuang, Liu, Jianwei, Fan, Guanwei, Lyu, Ming, Zhu, Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618804/ https://www.ncbi.nlm.nih.gov/pubmed/36325326 http://dx.doi.org/10.3389/fimmu.2022.1007341

Ejemplares similares

Dunye Guanxinning Improves Acute Myocardial Ischemia-Reperfusion Injury by Inhibiting Neutrophil Infiltration and Caspase-1 Activity
por: Zhang, Q. G., et al.
Publicado: (2018)

Guanxin V attenuates myocardial ischaemia reperfusion injury through regulating iron homeostasis
por: Zhou, Fuqiong, et al.
Publicado: (2022)

Guanxin Danshen Formulation Protects against Myocardial Ischemia Reperfusion Injury-Induced Left Ventricular Remodeling by Upregulating Estrogen Receptor β
por: Deng, Xuehong, et al.
Publicado: (2017)

Ginkgo Flavonol Glycosides or Ginkgolides Tend to Differentially Protect Myocardial or Cerebral Ischemia–Reperfusion Injury via Regulation of TWEAK-Fn14 Signaling in Heart and Brain
por: Xiao, Guangxu, et al.
Publicado: (2019)

Guanxinning Injection Combined With Ischemic Postconditioning Attenuate Myocardial Ischemic Reperfusion Injury in Chronic Renal Failure Rats by Modulating Mitochondrial Dynamics
por: Wang, Anzhu, et al.
Publicado: (2022)

Guanxin V Acts as an Antioxidant in Ventricular Remodeling
por: Liang, Bo, et al.
Publicado: (2022)

Podocyte NF‐κB is dispensable for the pathogenesis of renal ischemia‐reperfusion injury
por: Yamashita, Maho, et al.
Publicado: (2016)

Protective effect of Guanxin Danshen formula on myocardial ischemiareperfusion injury in rats
por: Li, Lanfang, et al.
Publicado: (2023)

The Anti-Inflammatory Effects of CXCR5 in the Mice Retina following Ischemia-Reperfusion Injury
por: Cao, Xing, et al.
Publicado: (2019)

Effect of Guanxin V in animal model of acute myocardial infarction
por: Zhang, Xiaoxiao, et al.
Publicado: (2021)

CXCR3 alleviates renal ischemia-reperfusion injury via increase of Tregs
por: Xian, Wenjing, et al.
Publicado: (2021)

The effect of focal cerebral ischemia-reperfusion injury on TLR4 and NF-κB signaling pathway
por: Chen, Jing, et al.
Publicado: (2018)

Isoflurane suppresses lung ischemia-reperfusion injury by inactivating NF-κB and inhibiting cell apoptosis
por: Lv, Ning, et al.
Publicado: (2020)

Effects of Farnesiferol B on Ischemia-Reperfusion-Induced Renal Damage, Inflammation, and NF-κB Signaling
por: Zhang, Lu, et al.
Publicado: (2019)

Artemisinin protects against cerebral ischemia and reperfusion injury via inhibiting the NF-κB pathway
por: Ji, Hui, et al.
Publicado: (2022)

Neuroprotection of Dexmedetomidine against Cerebral Ischemia-Reperfusion Injury in Rats: Involved in Inhibition of NF-κB and Inflammation Response
por: Wang, Lijun, et al.
Publicado: (2017)

Pterostilbene Attenuates Astrocytic Inflammation and Neuronal Oxidative Injury After Ischemia-Reperfusion by Inhibiting NF-κB Phosphorylation
por: Liu, Haixiao, et al.
Publicado: (2019)

Brazilin exerts protective effects against renal ischemia-reperfusion injury by inhibiting the NF-κB signaling pathway
por: JIA, YANYAN, et al.
Publicado: (2016)

Transcription factors Nrf2 and NF-κB contribute to inflammation and apoptosis induced by intestinal ischemia-reperfusion in mice
por: Meng, Qing-Tao, et al.
Publicado: (2017)

Quercetin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy by Inhibiting ERK/NF-κB Pathway
por: Wu, Liwei, et al.
Publicado: (2017)

The Role of SDF-1-CXCR4/CXCR7 Axis in the Therapeutic Effects of Hypoxia-Preconditioned Mesenchymal Stem Cells for Renal Ischemia/Reperfusion Injury
por: Liu, Hongbao, et al.
Publicado: (2012)

The Efficacy of Guanxinning Injection in Treating Angina Pectoris: Systematic Review and Meta-Analysis of Randomized Controlled Trials
por: Jia, Yongliang, et al.
Publicado: (2013)

Agaricoglycerides Protect against Hepatic Ischemia/Reperfusion Injury by Attenuating Inflammatory Response, Oxidative Stress, and Expression of NF-κB
por: Zhao, Xiang-qian, et al.
Publicado: (2015)

Correction to: Bilobalide protects against ischemia/reperfusion-induced oxidative stress and inflammatory responses via the MAPK/NF-κB pathways in rats
por: Li, Ying, et al.
Publicado: (2020)

Inactivated Lactobacillus promotes protection against myocardial ischemia–reperfusion injury through NF-κB pathway
por: Wang, Ni, et al.
Publicado: (2017)

Effects of SB202190 on expression levels of IL-6 and NF-κB in flap ischemia-reperfusion injury
por: Guo, Kai, et al.
Publicado: (2018)

Vildagliptin Attenuates Hepatic Ischemia/Reperfusion Injury via the TLR4/NF-κB Signaling Pathway
por: Sherif, Iman O., et al.
Publicado: (2018)

Febuxostat Modulates MAPK/NF-κBp65/TNF-α Signaling in Cardiac Ischemia-Reperfusion Injury
por: Khan, Sana Irfan, et al.
Publicado: (2017)

Effect of β-patchoulene on cerebral ischemia-reperfusion injury and the TLR4/NF-κB signaling pathway
por: Zhang, Fu-Bo, et al.
Publicado: (2019)

Pioglitazone Ameliorates Renal Ischemia-Reperfusion Injury via Inhibition of NF-κB Activation and Inflammation in Rats
por: Zou, Gaode, et al.
Publicado: (2021)

Cordycepin Protects against Hepatic Ischemia/Reperfusion Injury via Inhibiting MAPK/NF-κB Pathway
por: Ding, Jiameng, et al.
Publicado: (2022)

Ginsenoside Rb3 Protects Cardiomyocytes against Ischemia-Reperfusion Injury via the Inhibition of JNK-Mediated NF-κB Pathway: A Mouse Cardiomyocyte Model
por: Ma, Lijia, et al.
Publicado: (2014)

Biochanin A attenuates myocardial ischemia/reperfusion injury through the TLR4/NF-κB/NLRP3 signaling pathway
por: Bai, Yejun, et al.
Publicado: (2019)

Signal peptide mutations in RANK prevent downstream activation of NF-κB
por: Crockett, Julie C, et al.
Publicado: (2011)

The Effect of Metadherin on NF-κB Activation and Downstream Genes in Ovarian Cancer
por: Rong, Chunhong, et al.
Publicado: (2020)

Study of Guanxinning Injection on Regulatory Mechanism of Bcl-2 and Bax by Liquid Nitrogen Freezing-Mediated Femoral Head Necrosis
por: Zhang, Xiaofeng, et al.
Publicado: (2017)

Tnfrsf12a-Mediated Atherosclerosis Signaling and Inflammatory Response as a Common Protection Mechanism of Shuxuening Injection Against Both Myocardial and Cerebral Ischemia-Reperfusion Injuries
por: Lyu, Ming, et al.
Publicado: (2018)

Synergistic Effects of Cryptotanshinone and Senkyunolide I in Guanxinning Tablet Against Endogenous Thrombus Formation in Zebrafish
por: Li, Jun, et al.
Publicado: (2021)

Mangiferin Attenuates Myocardial Ischemia-Reperfusion Injury via MAPK/Nrf-2/HO-1/NF-κB In Vitro and In Vivo
por: Liu, Kun, et al.
Publicado: (2019)

Protective effects of dexmedetomidine on cerebral ischemia/reperfusion injury via the microRNA-214/ROCK1/NF-κB axis
por: Liu, Wenyi, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_sun1v29qi8pilhbhbj8vijssp0