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Frailty and long-term survival of patients with ovarian cancer: A systematic review and meta-analysis
BACKGROUND: Frailty has been related with poor prognosis of various diseases, including ovarian cancer. We performed a systematic review and meta-analysis to evaluate the association between frailty and long-term survival of patients with ovarian cancer. METHODS: Relevant cohort studies were retriev...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618815/ https://www.ncbi.nlm.nih.gov/pubmed/36324564 http://dx.doi.org/10.3389/fonc.2022.1007834 |
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author | Li, Kemin Yin, Rutie Li, Zhengyu |
author_facet | Li, Kemin Yin, Rutie Li, Zhengyu |
author_sort | Li, Kemin |
collection | PubMed |
description | BACKGROUND: Frailty has been related with poor prognosis of various diseases, including ovarian cancer. We performed a systematic review and meta-analysis to evaluate the association between frailty and long-term survival of patients with ovarian cancer. METHODS: Relevant cohort studies were retrieved by search of PubMed, Embase, Cochrane’s Library, and Web of Science electronic databases. Two authors independently performed literature search, data collection, and statistical analyses. A random-effect model incorporating the possible influence of heterogeneity was used to pool the results. RESULTS: Nine cohort studies including 2497 women with confirmed diagnosis of ovarian cancer contributed to the meta-analysis, and 536 (21.5%) of them were with high frailty. The median follow-up durations varied between 24 and 69 months. Compared to patients with low or non-frailty, OC patients with high frailty were associated with poor overall survival (risk ratio [RR]: 1.61, 95% confidence interval [CI]: 1.41 to 1.85, p < 0.001; I(2) = 0%) and progression-free survival (RR: 1.51, 95% CI: 1.20 to 1.89, p < 0.001; I(2) = 0%). Subgroup analyses according to study design, cancer stage, age of patients, scales for frailty evaluation, follow-up duration, and quality score of the included study showed consistent association between high frailty and poor overall survival in women with ovarian cancer (p for subgroup effects all < 0.05). After considering GRADE criteria for strength of the evidence, it was rated low for both the two outcomes. CONCLUSION: High frailty may be an independent risk factor of poor survival in women with ovarian cancer. Evaluating frailty may be important for predicting the prognosis and determining the optimal anticancer treatments in women with ovarian cancer. SYSTEMATIC REVIEW REGISTRATION: https://inplasy.com/, identifier INPLASY202290028. |
format | Online Article Text |
id | pubmed-9618815 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96188152022-11-01 Frailty and long-term survival of patients with ovarian cancer: A systematic review and meta-analysis Li, Kemin Yin, Rutie Li, Zhengyu Front Oncol Oncology BACKGROUND: Frailty has been related with poor prognosis of various diseases, including ovarian cancer. We performed a systematic review and meta-analysis to evaluate the association between frailty and long-term survival of patients with ovarian cancer. METHODS: Relevant cohort studies were retrieved by search of PubMed, Embase, Cochrane’s Library, and Web of Science electronic databases. Two authors independently performed literature search, data collection, and statistical analyses. A random-effect model incorporating the possible influence of heterogeneity was used to pool the results. RESULTS: Nine cohort studies including 2497 women with confirmed diagnosis of ovarian cancer contributed to the meta-analysis, and 536 (21.5%) of them were with high frailty. The median follow-up durations varied between 24 and 69 months. Compared to patients with low or non-frailty, OC patients with high frailty were associated with poor overall survival (risk ratio [RR]: 1.61, 95% confidence interval [CI]: 1.41 to 1.85, p < 0.001; I(2) = 0%) and progression-free survival (RR: 1.51, 95% CI: 1.20 to 1.89, p < 0.001; I(2) = 0%). Subgroup analyses according to study design, cancer stage, age of patients, scales for frailty evaluation, follow-up duration, and quality score of the included study showed consistent association between high frailty and poor overall survival in women with ovarian cancer (p for subgroup effects all < 0.05). After considering GRADE criteria for strength of the evidence, it was rated low for both the two outcomes. CONCLUSION: High frailty may be an independent risk factor of poor survival in women with ovarian cancer. Evaluating frailty may be important for predicting the prognosis and determining the optimal anticancer treatments in women with ovarian cancer. SYSTEMATIC REVIEW REGISTRATION: https://inplasy.com/, identifier INPLASY202290028. Frontiers Media S.A. 2022-10-17 /pmc/articles/PMC9618815/ /pubmed/36324564 http://dx.doi.org/10.3389/fonc.2022.1007834 Text en Copyright © 2022 Li, Yin and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Li, Kemin Yin, Rutie Li, Zhengyu Frailty and long-term survival of patients with ovarian cancer: A systematic review and meta-analysis |
title | Frailty and long-term survival of patients with ovarian cancer: A systematic review and meta-analysis |
title_full | Frailty and long-term survival of patients with ovarian cancer: A systematic review and meta-analysis |
title_fullStr | Frailty and long-term survival of patients with ovarian cancer: A systematic review and meta-analysis |
title_full_unstemmed | Frailty and long-term survival of patients with ovarian cancer: A systematic review and meta-analysis |
title_short | Frailty and long-term survival of patients with ovarian cancer: A systematic review and meta-analysis |
title_sort | frailty and long-term survival of patients with ovarian cancer: a systematic review and meta-analysis |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618815/ https://www.ncbi.nlm.nih.gov/pubmed/36324564 http://dx.doi.org/10.3389/fonc.2022.1007834 |
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