Mechanotransduction in skin wound healing and scar formation: Potential therapeutic targets for controlling hypertrophic scarring

Hypertrophic scarring (HTS) is a major source of morbidity after cutaneous injury. Recent studies indicate that mechanical force significantly impacts wound healing and skin regeneration which opens up a new direction to combat scarring. Hence, a thorough understanding of the underlying mechanisms i...

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Autores principales: Yin, Jiayi, Zhang, Shiming, Yang, Chao, Wang, Yan, Shi, Bing, Zheng, Qian, Zeng, Ni, Huang, Hanyao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618819/
https://www.ncbi.nlm.nih.gov/pubmed/36325354
http://dx.doi.org/10.3389/fimmu.2022.1028410
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author Yin, Jiayi
Zhang, Shiming
Yang, Chao
Wang, Yan
Shi, Bing
Zheng, Qian
Zeng, Ni
Huang, Hanyao
author_facet Yin, Jiayi
Zhang, Shiming
Yang, Chao
Wang, Yan
Shi, Bing
Zheng, Qian
Zeng, Ni
Huang, Hanyao
author_sort Yin, Jiayi
collection PubMed
description Hypertrophic scarring (HTS) is a major source of morbidity after cutaneous injury. Recent studies indicate that mechanical force significantly impacts wound healing and skin regeneration which opens up a new direction to combat scarring. Hence, a thorough understanding of the underlying mechanisms is essential in the development of efficacious scar therapeutics. This review provides an overview of the current understanding of the mechanotransduction signaling pathways in scar formation and some strategies that offload mechanical forces in the wounded region for scar prevention and treatment.
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spelling pubmed-96188192022-11-01 Mechanotransduction in skin wound healing and scar formation: Potential therapeutic targets for controlling hypertrophic scarring Yin, Jiayi Zhang, Shiming Yang, Chao Wang, Yan Shi, Bing Zheng, Qian Zeng, Ni Huang, Hanyao Front Immunol Immunology Hypertrophic scarring (HTS) is a major source of morbidity after cutaneous injury. Recent studies indicate that mechanical force significantly impacts wound healing and skin regeneration which opens up a new direction to combat scarring. Hence, a thorough understanding of the underlying mechanisms is essential in the development of efficacious scar therapeutics. This review provides an overview of the current understanding of the mechanotransduction signaling pathways in scar formation and some strategies that offload mechanical forces in the wounded region for scar prevention and treatment. Frontiers Media S.A. 2022-10-17 /pmc/articles/PMC9618819/ /pubmed/36325354 http://dx.doi.org/10.3389/fimmu.2022.1028410 Text en Copyright © 2022 Yin, Zhang, Yang, Wang, Shi, Zheng, Zeng and Huang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Yin, Jiayi
Zhang, Shiming
Yang, Chao
Wang, Yan
Shi, Bing
Zheng, Qian
Zeng, Ni
Huang, Hanyao
Mechanotransduction in skin wound healing and scar formation: Potential therapeutic targets for controlling hypertrophic scarring
title Mechanotransduction in skin wound healing and scar formation: Potential therapeutic targets for controlling hypertrophic scarring
title_full Mechanotransduction in skin wound healing and scar formation: Potential therapeutic targets for controlling hypertrophic scarring
title_fullStr Mechanotransduction in skin wound healing and scar formation: Potential therapeutic targets for controlling hypertrophic scarring
title_full_unstemmed Mechanotransduction in skin wound healing and scar formation: Potential therapeutic targets for controlling hypertrophic scarring
title_short Mechanotransduction in skin wound healing and scar formation: Potential therapeutic targets for controlling hypertrophic scarring
title_sort mechanotransduction in skin wound healing and scar formation: potential therapeutic targets for controlling hypertrophic scarring
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618819/
https://www.ncbi.nlm.nih.gov/pubmed/36325354
http://dx.doi.org/10.3389/fimmu.2022.1028410
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