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Diagnostic Value of DCE-MRI for Differentiating Malignant Adnexal Masses Compared with Contrast-enhanced-T1WI
Purpose: To compare the diagnostic performance of dynamic contrast-enhanced-MR (DCE-MR) and delayed contrast-enhanced (CE)-MRI added to unenhanced MRI, including diffusion weighted image (DWI) for differentiating malignant adnexal tumors, conducting a retrospective blinded image interpretation study...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Japanese Society for Magnetic Resonance in Medicine
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618924/ https://www.ncbi.nlm.nih.gov/pubmed/34483226 http://dx.doi.org/10.2463/mrms.mp.2021-0003 |
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author | Otani, Satoshi Kido, Aki Himoto, Yuki Sakata, Akihiko Otani, Tomoaki Kuwahara, Ryo Moribata, Yusaku Nishio, Naoko Yajima, Ryo Nakao, Kyoko Kurata, Yasuhisa Minamiguchi, Sachiko Mandai, Masaki Nakamoto, Yuji |
author_facet | Otani, Satoshi Kido, Aki Himoto, Yuki Sakata, Akihiko Otani, Tomoaki Kuwahara, Ryo Moribata, Yusaku Nishio, Naoko Yajima, Ryo Nakao, Kyoko Kurata, Yasuhisa Minamiguchi, Sachiko Mandai, Masaki Nakamoto, Yuji |
author_sort | Otani, Satoshi |
collection | PubMed |
description | Purpose: To compare the diagnostic performance of dynamic contrast-enhanced-MR (DCE-MR) and delayed contrast-enhanced (CE)-MRI added to unenhanced MRI, including diffusion weighted image (DWI) for differentiating malignant adnexal tumors, conducting a retrospective blinded image interpretation study. Methods: Data of 80 patients suspected of having adnexal tumors by ultrasonography between April 2008 and August 2018 were used for the study. All patients had undergone preoperative MRI and surgical resection at our institution. Four radiologists (two specialized in gynecological radiology and two non-specialized) were enrolled for blinded review of the MR images. A 3-point scale was used: 0 = benign, 1 = indeterminate, and 2 = malignant. Three imaging sets were reviewed: Set A, unenhanced MRI including DWI; Set B, Set A and delayed CE-T1WI; and Set C, Set A and DCE-MRI. Imaging criteria for benign and malignant tumors were given in earlier reports. The diagnostic performance of the three imaging sets of the four readers was calculated. Their areas under the curve (AUCs) were compared using the DeLong method. Results: Accuracies of Set B were 81%–88%. Those of Set C were 81%–85%. The AUCs of Set B were 0.83 and 0.89. Those of Set C were 0.81–0.86. For two readers, Set A showed lower accuracy and AUC than Set B/Set C (less than 0.80), although those were equivalent in other readers. No significant difference in AUCs was found among the three sequence sets. Intrareader agreement was moderate to almost perfect in Sets A and B, and substantial to almost perfect in Set C. Conclusion: DCE-MR showed no superiority for differentiating malignant adnexal tumors from benign tumors compared to delayed CE-T1WI with conventional MR and DWI. |
format | Online Article Text |
id | pubmed-9618924 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Japanese Society for Magnetic Resonance in Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-96189242022-11-14 Diagnostic Value of DCE-MRI for Differentiating Malignant Adnexal Masses Compared with Contrast-enhanced-T1WI Otani, Satoshi Kido, Aki Himoto, Yuki Sakata, Akihiko Otani, Tomoaki Kuwahara, Ryo Moribata, Yusaku Nishio, Naoko Yajima, Ryo Nakao, Kyoko Kurata, Yasuhisa Minamiguchi, Sachiko Mandai, Masaki Nakamoto, Yuji Magn Reson Med Sci Major Paper Purpose: To compare the diagnostic performance of dynamic contrast-enhanced-MR (DCE-MR) and delayed contrast-enhanced (CE)-MRI added to unenhanced MRI, including diffusion weighted image (DWI) for differentiating malignant adnexal tumors, conducting a retrospective blinded image interpretation study. Methods: Data of 80 patients suspected of having adnexal tumors by ultrasonography between April 2008 and August 2018 were used for the study. All patients had undergone preoperative MRI and surgical resection at our institution. Four radiologists (two specialized in gynecological radiology and two non-specialized) were enrolled for blinded review of the MR images. A 3-point scale was used: 0 = benign, 1 = indeterminate, and 2 = malignant. Three imaging sets were reviewed: Set A, unenhanced MRI including DWI; Set B, Set A and delayed CE-T1WI; and Set C, Set A and DCE-MRI. Imaging criteria for benign and malignant tumors were given in earlier reports. The diagnostic performance of the three imaging sets of the four readers was calculated. Their areas under the curve (AUCs) were compared using the DeLong method. Results: Accuracies of Set B were 81%–88%. Those of Set C were 81%–85%. The AUCs of Set B were 0.83 and 0.89. Those of Set C were 0.81–0.86. For two readers, Set A showed lower accuracy and AUC than Set B/Set C (less than 0.80), although those were equivalent in other readers. No significant difference in AUCs was found among the three sequence sets. Intrareader agreement was moderate to almost perfect in Sets A and B, and substantial to almost perfect in Set C. Conclusion: DCE-MR showed no superiority for differentiating malignant adnexal tumors from benign tumors compared to delayed CE-T1WI with conventional MR and DWI. Japanese Society for Magnetic Resonance in Medicine 2021-09-03 /pmc/articles/PMC9618924/ /pubmed/34483226 http://dx.doi.org/10.2463/mrms.mp.2021-0003 Text en ©2021 Japanese Society for Magnetic Resonance in Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Major Paper Otani, Satoshi Kido, Aki Himoto, Yuki Sakata, Akihiko Otani, Tomoaki Kuwahara, Ryo Moribata, Yusaku Nishio, Naoko Yajima, Ryo Nakao, Kyoko Kurata, Yasuhisa Minamiguchi, Sachiko Mandai, Masaki Nakamoto, Yuji Diagnostic Value of DCE-MRI for Differentiating Malignant Adnexal Masses Compared with Contrast-enhanced-T1WI |
title | Diagnostic Value of DCE-MRI for Differentiating Malignant Adnexal Masses Compared with Contrast-enhanced-T1WI |
title_full | Diagnostic Value of DCE-MRI for Differentiating Malignant Adnexal Masses Compared with Contrast-enhanced-T1WI |
title_fullStr | Diagnostic Value of DCE-MRI for Differentiating Malignant Adnexal Masses Compared with Contrast-enhanced-T1WI |
title_full_unstemmed | Diagnostic Value of DCE-MRI for Differentiating Malignant Adnexal Masses Compared with Contrast-enhanced-T1WI |
title_short | Diagnostic Value of DCE-MRI for Differentiating Malignant Adnexal Masses Compared with Contrast-enhanced-T1WI |
title_sort | diagnostic value of dce-mri for differentiating malignant adnexal masses compared with contrast-enhanced-t1wi |
topic | Major Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618924/ https://www.ncbi.nlm.nih.gov/pubmed/34483226 http://dx.doi.org/10.2463/mrms.mp.2021-0003 |
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