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Association of BDNF and MMP-9 single-nucleotide polymorphisms with the clinical phenotype of schizophrenia
OBJECTIVE: Schizophrenia is a highly polygenic psychiatric disorder; however, the complex genetic architecture underlying the pathogenesis remains elusive. Brain-derived neurotrophic factor (BDNF), a neurotrophin, and matrix metalloproteinase 9 (MMP-9), a gelatinase B, are the promising candidate ge...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9619044/ https://www.ncbi.nlm.nih.gov/pubmed/36325525 http://dx.doi.org/10.3389/fpsyt.2022.941973 |
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author | Pan, Lihong Cao, Zhonghai Chen, Lianghu Qian, Min Yan, Yuzhong |
author_facet | Pan, Lihong Cao, Zhonghai Chen, Lianghu Qian, Min Yan, Yuzhong |
author_sort | Pan, Lihong |
collection | PubMed |
description | OBJECTIVE: Schizophrenia is a highly polygenic psychiatric disorder; however, the complex genetic architecture underlying the pathogenesis remains elusive. Brain-derived neurotrophic factor (BDNF), a neurotrophin, and matrix metalloproteinase 9 (MMP-9), a gelatinase B, are the promising candidate genes for schizophrenia. To shed new light on the relationship between the single-nucleotide polymorphisms (SNPs) of BDNF and MMP-9 and the clinical variability of schizophrenia phenotype, this study aims to evaluate the relationship, and provide more definitive evidence for the relationship with various clinical features of schizophrenia. METHODS: A case-control association study was performed, and one hundred and five subjects of Chinese Han population were enrolled, including 55 schizophrenia patients (SP) and 50 healthy controls (HC). The BDNF rs6265 196 G > A and MMP-9 rs3918242 −1562C > T SNPs were genotyped using PCR-RFLP assay. The Positive and Negative Syndrome Scale (PANSS) was used to assess the clinical symptoms of patients with schizophrenia. RESULTS: Compared with HC, the frequency of SP carrying BDNF rs6265 GG/GA genotype was significantly higher than HC, and the frequency of SP carrying BDNF rs6265 AA genotype was significantly lower than HC (p < 0.01). With regards to MMP-9 rs3918242 −1562C > T SNP, no significant difference was observed between the control and SP. BDNF GG genotype showed significantly higher PANSS and positive symptoms score than GA and AA genotypes (P < 0.01). MMP-9 CC genotype showed significantly higher PANSS and general score than CT and TT genotypes (P < 0.05). CONCLUSION: BDNF rs6265 196 G > A and MMP-9 rs3918242–1562C > T SNPs are related to the clinical features of schizophrenia and could be a useful biomarker for the changes, remission or deterioration of clinical status of schizophrenia. |
format | Online Article Text |
id | pubmed-9619044 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96190442022-11-01 Association of BDNF and MMP-9 single-nucleotide polymorphisms with the clinical phenotype of schizophrenia Pan, Lihong Cao, Zhonghai Chen, Lianghu Qian, Min Yan, Yuzhong Front Psychiatry Psychiatry OBJECTIVE: Schizophrenia is a highly polygenic psychiatric disorder; however, the complex genetic architecture underlying the pathogenesis remains elusive. Brain-derived neurotrophic factor (BDNF), a neurotrophin, and matrix metalloproteinase 9 (MMP-9), a gelatinase B, are the promising candidate genes for schizophrenia. To shed new light on the relationship between the single-nucleotide polymorphisms (SNPs) of BDNF and MMP-9 and the clinical variability of schizophrenia phenotype, this study aims to evaluate the relationship, and provide more definitive evidence for the relationship with various clinical features of schizophrenia. METHODS: A case-control association study was performed, and one hundred and five subjects of Chinese Han population were enrolled, including 55 schizophrenia patients (SP) and 50 healthy controls (HC). The BDNF rs6265 196 G > A and MMP-9 rs3918242 −1562C > T SNPs were genotyped using PCR-RFLP assay. The Positive and Negative Syndrome Scale (PANSS) was used to assess the clinical symptoms of patients with schizophrenia. RESULTS: Compared with HC, the frequency of SP carrying BDNF rs6265 GG/GA genotype was significantly higher than HC, and the frequency of SP carrying BDNF rs6265 AA genotype was significantly lower than HC (p < 0.01). With regards to MMP-9 rs3918242 −1562C > T SNP, no significant difference was observed between the control and SP. BDNF GG genotype showed significantly higher PANSS and positive symptoms score than GA and AA genotypes (P < 0.01). MMP-9 CC genotype showed significantly higher PANSS and general score than CT and TT genotypes (P < 0.05). CONCLUSION: BDNF rs6265 196 G > A and MMP-9 rs3918242–1562C > T SNPs are related to the clinical features of schizophrenia and could be a useful biomarker for the changes, remission or deterioration of clinical status of schizophrenia. Frontiers Media S.A. 2022-10-17 /pmc/articles/PMC9619044/ /pubmed/36325525 http://dx.doi.org/10.3389/fpsyt.2022.941973 Text en Copyright © 2022 Pan, Cao, Chen, Qian and Yan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Pan, Lihong Cao, Zhonghai Chen, Lianghu Qian, Min Yan, Yuzhong Association of BDNF and MMP-9 single-nucleotide polymorphisms with the clinical phenotype of schizophrenia |
title | Association of BDNF and MMP-9 single-nucleotide polymorphisms with the clinical phenotype of schizophrenia |
title_full | Association of BDNF and MMP-9 single-nucleotide polymorphisms with the clinical phenotype of schizophrenia |
title_fullStr | Association of BDNF and MMP-9 single-nucleotide polymorphisms with the clinical phenotype of schizophrenia |
title_full_unstemmed | Association of BDNF and MMP-9 single-nucleotide polymorphisms with the clinical phenotype of schizophrenia |
title_short | Association of BDNF and MMP-9 single-nucleotide polymorphisms with the clinical phenotype of schizophrenia |
title_sort | association of bdnf and mmp-9 single-nucleotide polymorphisms with the clinical phenotype of schizophrenia |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9619044/ https://www.ncbi.nlm.nih.gov/pubmed/36325525 http://dx.doi.org/10.3389/fpsyt.2022.941973 |
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