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Usefulness of phase gradients of otoacoustic emissions in auditory health screening: An exploration with swept tones
Otoacoustic emissions (OAEs) are low-level sounds generated by the cochlea and widely used as a noninvasive tool to inspect cochlear impairments. However, only the amplitude information of OAE signals is used in current clinical tests, while the OAE phase containing important information about cochl...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9619081/ https://www.ncbi.nlm.nih.gov/pubmed/36325482 http://dx.doi.org/10.3389/fnins.2022.1018916 |
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author | Wang, Xin Zhu, Mingxing He, Yuchao Liu, Zhenzhen Huang, Xin Pan, Hongguang Wang, Mingjiang Chen, Shixiong Tao, Yuan Li, Guanglin |
author_facet | Wang, Xin Zhu, Mingxing He, Yuchao Liu, Zhenzhen Huang, Xin Pan, Hongguang Wang, Mingjiang Chen, Shixiong Tao, Yuan Li, Guanglin |
author_sort | Wang, Xin |
collection | PubMed |
description | Otoacoustic emissions (OAEs) are low-level sounds generated by the cochlea and widely used as a noninvasive tool to inspect cochlear impairments. However, only the amplitude information of OAE signals is used in current clinical tests, while the OAE phase containing important information about cochlear functions is commonly discarded, due to the insufficient frequency-resolution of existing OAE tests. In this study, swept tones with time-varying frequencies were used to measure stimulus frequency OAEs (SFOAEs) in human subjects, so that high-resolution phase spectra that are not available in existing OAE tests could be obtained and analyzed. The results showed that the phase of swept-tone SFOAEs demonstrated steep gradients as the frequency increased in human subjects with normal hearing. The steep phase gradients were sensitive to auditory functional abnormality caused by cochlear damage and stimulus artifacts introduced by system distortions. At low stimulus levels, the group delays derived from the phase gradients decreased from around 8.5 to 3 ms as the frequency increased from 1 to 10 kHz for subjects with normal hearing, and the pattern of group-delay versus frequency function showed significant difference for subjects with hearing loss. By using the swept-tone technology, the study suggests that the OAE phase gradients could provide highly sensitive information about the cochlear functions and therefore should be integrated into the conventional methods to improve the reliability of auditory health screening. |
format | Online Article Text |
id | pubmed-9619081 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96190812022-11-01 Usefulness of phase gradients of otoacoustic emissions in auditory health screening: An exploration with swept tones Wang, Xin Zhu, Mingxing He, Yuchao Liu, Zhenzhen Huang, Xin Pan, Hongguang Wang, Mingjiang Chen, Shixiong Tao, Yuan Li, Guanglin Front Neurosci Neuroscience Otoacoustic emissions (OAEs) are low-level sounds generated by the cochlea and widely used as a noninvasive tool to inspect cochlear impairments. However, only the amplitude information of OAE signals is used in current clinical tests, while the OAE phase containing important information about cochlear functions is commonly discarded, due to the insufficient frequency-resolution of existing OAE tests. In this study, swept tones with time-varying frequencies were used to measure stimulus frequency OAEs (SFOAEs) in human subjects, so that high-resolution phase spectra that are not available in existing OAE tests could be obtained and analyzed. The results showed that the phase of swept-tone SFOAEs demonstrated steep gradients as the frequency increased in human subjects with normal hearing. The steep phase gradients were sensitive to auditory functional abnormality caused by cochlear damage and stimulus artifacts introduced by system distortions. At low stimulus levels, the group delays derived from the phase gradients decreased from around 8.5 to 3 ms as the frequency increased from 1 to 10 kHz for subjects with normal hearing, and the pattern of group-delay versus frequency function showed significant difference for subjects with hearing loss. By using the swept-tone technology, the study suggests that the OAE phase gradients could provide highly sensitive information about the cochlear functions and therefore should be integrated into the conventional methods to improve the reliability of auditory health screening. Frontiers Media S.A. 2022-10-17 /pmc/articles/PMC9619081/ /pubmed/36325482 http://dx.doi.org/10.3389/fnins.2022.1018916 Text en Copyright © 2022 Wang, Zhu, He, Liu, Huang, Pan, Wang, Chen, Tao and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Wang, Xin Zhu, Mingxing He, Yuchao Liu, Zhenzhen Huang, Xin Pan, Hongguang Wang, Mingjiang Chen, Shixiong Tao, Yuan Li, Guanglin Usefulness of phase gradients of otoacoustic emissions in auditory health screening: An exploration with swept tones |
title | Usefulness of phase gradients of otoacoustic emissions in auditory health screening: An exploration with swept tones |
title_full | Usefulness of phase gradients of otoacoustic emissions in auditory health screening: An exploration with swept tones |
title_fullStr | Usefulness of phase gradients of otoacoustic emissions in auditory health screening: An exploration with swept tones |
title_full_unstemmed | Usefulness of phase gradients of otoacoustic emissions in auditory health screening: An exploration with swept tones |
title_short | Usefulness of phase gradients of otoacoustic emissions in auditory health screening: An exploration with swept tones |
title_sort | usefulness of phase gradients of otoacoustic emissions in auditory health screening: an exploration with swept tones |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9619081/ https://www.ncbi.nlm.nih.gov/pubmed/36325482 http://dx.doi.org/10.3389/fnins.2022.1018916 |
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