Novel transketolase inhibitor oroxylin A suppresses the non‐oxidative pentose phosphate pathway and hepatocellular carcinoma tumour growth in mice and patient‐derived organoids

BACKGROUND: Transketolase (TKT), a key rate‐limiting enzyme in the non‐oxidative branch of the pentose phosphate pathway (PPP), provides more than 85% of the ribose required for de novo nucleotide biosynthesis and promotes the development of hepatocellular carcinoma (HCC). Pharmacologic inhibition o...

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Detalles Bibliográficos
Autores principales: Jia, Dan, Liu, Chunliang, Zhu, Zhenyu, Cao, Yan, Wen, Wen, Hong, Zhanying, Liu, Yue, Liu, Erdong, Chen, Long, Chen, Chun, Gu, Yanqiu, Jiao, Binghua, Chai, Yifeng, Wang, Hong‐yang, Fu, Jing, Chen, Xiaofei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9619225/
https://www.ncbi.nlm.nih.gov/pubmed/36314067
http://dx.doi.org/10.1002/ctm2.1095

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