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Beta-(1,3/1,6)-D-glucan from Pleurotus ostreatus in the prevention of recurrent respiratory tract infections: An international, multicentre, open-label, prospective study

Preschool children are particularly susceptible to recurrent upper and lower respiratory tract infections due to their immune immaturity and other contributing factors. Preventing and/or treating children suffering from recurrent respiratory tract infections (RRTIs) is challenging, and it is importa...

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Autores principales: Rennerova, Zuzana, Picó Sirvent, Leandro, Carvajal Roca, Eva, Paśnik, Jarosław, Logar, Mateja, Milošević, Katarina, Majtan, Juraj, Jesenak, Milos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9619242/
https://www.ncbi.nlm.nih.gov/pubmed/36324817
http://dx.doi.org/10.3389/fped.2022.999701
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author Rennerova, Zuzana
Picó Sirvent, Leandro
Carvajal Roca, Eva
Paśnik, Jarosław
Logar, Mateja
Milošević, Katarina
Majtan, Juraj
Jesenak, Milos
author_facet Rennerova, Zuzana
Picó Sirvent, Leandro
Carvajal Roca, Eva
Paśnik, Jarosław
Logar, Mateja
Milošević, Katarina
Majtan, Juraj
Jesenak, Milos
author_sort Rennerova, Zuzana
collection PubMed
description Preschool children are particularly susceptible to recurrent upper and lower respiratory tract infections due to their immune immaturity and other contributing factors. Preventing and/or treating children suffering from recurrent respiratory tract infections (RRTIs) is challenging, and it is important to provide more clinical evidence about the safety and efficacy of natural immunomodulating preparations, including β-glucans. The aim of the present study was to assess the incidence of respiratory tract infections (RTIs) in children with a history of RRTIs for a period of 6 months (3 months of pleuran supplementation and 3 months of follow-up) compared with the same period from October to March of the previous year prior to enrolment in the study. A total of 1,030 children with a mean age of 3.49 ± 1.91 years from seven countries were included in this study. The total number of RTIs observed during the study period was significantly lower compared to the same period of the previous year (7.07 ± 2.89 vs. 3.87 ± 3.19; p < 0.001). Analysis of each type of RTI revealed significant reductions in the mean number and duration of infections for all RTI subtypes compared to the previous year. This study also confirmed the beneficial safety profile of pleuran supplementation. In conclusion, pleuran supplementation represents an interesting and prospective supplement in preventing respiratory infections and reveals new strategies for supporting immune functions in the paediatric population.
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spelling pubmed-96192422022-11-01 Beta-(1,3/1,6)-D-glucan from Pleurotus ostreatus in the prevention of recurrent respiratory tract infections: An international, multicentre, open-label, prospective study Rennerova, Zuzana Picó Sirvent, Leandro Carvajal Roca, Eva Paśnik, Jarosław Logar, Mateja Milošević, Katarina Majtan, Juraj Jesenak, Milos Front Pediatr Pediatrics Preschool children are particularly susceptible to recurrent upper and lower respiratory tract infections due to their immune immaturity and other contributing factors. Preventing and/or treating children suffering from recurrent respiratory tract infections (RRTIs) is challenging, and it is important to provide more clinical evidence about the safety and efficacy of natural immunomodulating preparations, including β-glucans. The aim of the present study was to assess the incidence of respiratory tract infections (RTIs) in children with a history of RRTIs for a period of 6 months (3 months of pleuran supplementation and 3 months of follow-up) compared with the same period from October to March of the previous year prior to enrolment in the study. A total of 1,030 children with a mean age of 3.49 ± 1.91 years from seven countries were included in this study. The total number of RTIs observed during the study period was significantly lower compared to the same period of the previous year (7.07 ± 2.89 vs. 3.87 ± 3.19; p < 0.001). Analysis of each type of RTI revealed significant reductions in the mean number and duration of infections for all RTI subtypes compared to the previous year. This study also confirmed the beneficial safety profile of pleuran supplementation. In conclusion, pleuran supplementation represents an interesting and prospective supplement in preventing respiratory infections and reveals new strategies for supporting immune functions in the paediatric population. Frontiers Media S.A. 2022-10-14 /pmc/articles/PMC9619242/ /pubmed/36324817 http://dx.doi.org/10.3389/fped.2022.999701 Text en © 2022 Rennerova, Picó Sirvent, Carvajal Roca, Paśnik, Logar, Milošević, Majtan and Jesenak. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Rennerova, Zuzana
Picó Sirvent, Leandro
Carvajal Roca, Eva
Paśnik, Jarosław
Logar, Mateja
Milošević, Katarina
Majtan, Juraj
Jesenak, Milos
Beta-(1,3/1,6)-D-glucan from Pleurotus ostreatus in the prevention of recurrent respiratory tract infections: An international, multicentre, open-label, prospective study
title Beta-(1,3/1,6)-D-glucan from Pleurotus ostreatus in the prevention of recurrent respiratory tract infections: An international, multicentre, open-label, prospective study
title_full Beta-(1,3/1,6)-D-glucan from Pleurotus ostreatus in the prevention of recurrent respiratory tract infections: An international, multicentre, open-label, prospective study
title_fullStr Beta-(1,3/1,6)-D-glucan from Pleurotus ostreatus in the prevention of recurrent respiratory tract infections: An international, multicentre, open-label, prospective study
title_full_unstemmed Beta-(1,3/1,6)-D-glucan from Pleurotus ostreatus in the prevention of recurrent respiratory tract infections: An international, multicentre, open-label, prospective study
title_short Beta-(1,3/1,6)-D-glucan from Pleurotus ostreatus in the prevention of recurrent respiratory tract infections: An international, multicentre, open-label, prospective study
title_sort beta-(1,3/1,6)-d-glucan from pleurotus ostreatus in the prevention of recurrent respiratory tract infections: an international, multicentre, open-label, prospective study
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9619242/
https://www.ncbi.nlm.nih.gov/pubmed/36324817
http://dx.doi.org/10.3389/fped.2022.999701
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