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Catalytic anti-oxidative stress for osteoarthritis treatment by few-layered phosphorene

As one of the most common representations of articular cartilage damage, osteoarthritis (OA) is characterized by the apoptosis and dysfunction of chondrocytes as well as the progressive degradation of extracellular matrix, of which the main components are glycosaminoglycan and type Ⅱ collagen. Few-l...

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Autores principales: Zhang, Xingyu, You, Yanling, Sun, Yaying, Guo, Xiang, Han Lin, Zong, Ming, Shi, Jianlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9619373/
https://www.ncbi.nlm.nih.gov/pubmed/36325424
http://dx.doi.org/10.1016/j.mtbio.2022.100462
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author Zhang, Xingyu
You, Yanling
Sun, Yaying
Guo, Xiang
Han Lin
Zong, Ming
Shi, Jianlin
author_facet Zhang, Xingyu
You, Yanling
Sun, Yaying
Guo, Xiang
Han Lin
Zong, Ming
Shi, Jianlin
author_sort Zhang, Xingyu
collection PubMed
description As one of the most common representations of articular cartilage damage, osteoarthritis (OA) is characterized by the apoptosis and dysfunction of chondrocytes as well as the progressive degradation of extracellular matrix, of which the main components are glycosaminoglycan and type Ⅱ collagen. Few-layered phosphorene (FLP) has been attracting great attentions in biomedical fields owing to the excellent capability of in-situ catalysis for scavenging oxidate-associated molecules, especially the reactive oxygen species (ROS) and reactive nitrogen species (RNS). Herein, FLP has been fabricated and employed for articular cartilage protection by means of deleting oxidate-associated molecules. The in vitro results show that as low as 200 ​μg/mL FLP is capable of diminishing oxidative damages on the osteoarthritic chondrocytes through the efficient elimination of ROS, H(2)O(2) and NO. Meanwhile, the cartilage matrix protection has also been achieved at 200 ​μg/mL FLP by the uniform restoration of glycosaminoglycan and type Ⅱ collagen. FLP enables the nanocatalytic treatment for the overloaded oxidative stress in the injured articular cartilage and represents a promising alternative for osteoarthritis therapy.
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spelling pubmed-96193732022-11-01 Catalytic anti-oxidative stress for osteoarthritis treatment by few-layered phosphorene Zhang, Xingyu You, Yanling Sun, Yaying Guo, Xiang Han Lin Zong, Ming Shi, Jianlin Mater Today Bio Full Length Article As one of the most common representations of articular cartilage damage, osteoarthritis (OA) is characterized by the apoptosis and dysfunction of chondrocytes as well as the progressive degradation of extracellular matrix, of which the main components are glycosaminoglycan and type Ⅱ collagen. Few-layered phosphorene (FLP) has been attracting great attentions in biomedical fields owing to the excellent capability of in-situ catalysis for scavenging oxidate-associated molecules, especially the reactive oxygen species (ROS) and reactive nitrogen species (RNS). Herein, FLP has been fabricated and employed for articular cartilage protection by means of deleting oxidate-associated molecules. The in vitro results show that as low as 200 ​μg/mL FLP is capable of diminishing oxidative damages on the osteoarthritic chondrocytes through the efficient elimination of ROS, H(2)O(2) and NO. Meanwhile, the cartilage matrix protection has also been achieved at 200 ​μg/mL FLP by the uniform restoration of glycosaminoglycan and type Ⅱ collagen. FLP enables the nanocatalytic treatment for the overloaded oxidative stress in the injured articular cartilage and represents a promising alternative for osteoarthritis therapy. Elsevier 2022-10-15 /pmc/articles/PMC9619373/ /pubmed/36325424 http://dx.doi.org/10.1016/j.mtbio.2022.100462 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Full Length Article
Zhang, Xingyu
You, Yanling
Sun, Yaying
Guo, Xiang
Han Lin
Zong, Ming
Shi, Jianlin
Catalytic anti-oxidative stress for osteoarthritis treatment by few-layered phosphorene
title Catalytic anti-oxidative stress for osteoarthritis treatment by few-layered phosphorene
title_full Catalytic anti-oxidative stress for osteoarthritis treatment by few-layered phosphorene
title_fullStr Catalytic anti-oxidative stress for osteoarthritis treatment by few-layered phosphorene
title_full_unstemmed Catalytic anti-oxidative stress for osteoarthritis treatment by few-layered phosphorene
title_short Catalytic anti-oxidative stress for osteoarthritis treatment by few-layered phosphorene
title_sort catalytic anti-oxidative stress for osteoarthritis treatment by few-layered phosphorene
topic Full Length Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9619373/
https://www.ncbi.nlm.nih.gov/pubmed/36325424
http://dx.doi.org/10.1016/j.mtbio.2022.100462
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