Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity

[Image: see text] LIM domain kinases 1 and 2 (LIMK1 and LIMK2) regulate actin dynamics and subsequently key cellular functions such as proliferation and migration. LIMK1 and LIMK2 phosphorylate and inactivate cofilin leading to increased actin polymerization. As a result, LIMK inhibitors are emergin...

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Detalles Bibliográficos
Autores principales: Collins, Ross, Lee, Hyunah, Jones, D. Heulyn, Elkins, Jonathan M., Gillespie, Jason A., Thomas, Carys, Baldwin, Alex G., Jones, Kimberley, Waters, Loren, Paine, Marie, Atack, John R., Ward, Simon E., Grubisha, Olivera, Foley, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9619402/
https://www.ncbi.nlm.nih.gov/pubmed/36205722
http://dx.doi.org/10.1021/acs.jmedchem.2c00751

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