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Discriminatory Ability of Gas Chromatography–Ion Mobility Spectrometry to Identify Patients Hospitalized With COVID-19 and Predict Prognosis
BACKGROUND: Rapid diagnostic and prognostic tests for coronavirus disease (COVID-19) are urgently required. We aimed to evaluate the diagnostic and prognostic ability of breath analysis using gas chromatography–ion mobility spectrometry (GC-IMS) in hospitalized patients with COVID-19. METHODS: Betwe...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9619573/ https://www.ncbi.nlm.nih.gov/pubmed/36345428 http://dx.doi.org/10.1093/ofid/ofac509 |
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author | Nazareth, Joshua Pan, Daniel Kim, Jee Whang Leach, Jack Brosnan, James G Ahmed, Adam Brodrick, Emma Bird, Paul Wicaksono, Alfian Daulton, Emma Tang, Julian W Williams, Caroline Haldar, Pranabashis Covington, James A Pareek, Manish Sahota, Amandip |
author_facet | Nazareth, Joshua Pan, Daniel Kim, Jee Whang Leach, Jack Brosnan, James G Ahmed, Adam Brodrick, Emma Bird, Paul Wicaksono, Alfian Daulton, Emma Tang, Julian W Williams, Caroline Haldar, Pranabashis Covington, James A Pareek, Manish Sahota, Amandip |
author_sort | Nazareth, Joshua |
collection | PubMed |
description | BACKGROUND: Rapid diagnostic and prognostic tests for coronavirus disease (COVID-19) are urgently required. We aimed to evaluate the diagnostic and prognostic ability of breath analysis using gas chromatography–ion mobility spectrometry (GC-IMS) in hospitalized patients with COVID-19. METHODS: Between February and May 2021, we took 1 breath sample for analysis using GC-IMS from participants who were admitted to the hospital for COVID-19, participants who were admitted to the hospital for other respiratory infections, and symptom-free controls, at the University Hospitals of Leicester NHS Trust, United Kingdom. Demographic, clinical, and radiological data, including requirement for continuous positive airway pressure (CPAP) ventilation as a marker for severe disease in the COVID-19 group, were collected. RESULTS: A total of 113 participants were recruited into the study. Seventy-two (64%) were diagnosed with COVID-19, 20 (18%) were diagnosed with another respiratory infection, and 21 (19%) were healthy controls. Differentiation between participants with COVID-19 and those with other respiratory tract infections with GC-IMS was highly accurate (sensitivity/specificity, 0.80/0.88; area under the receiver operating characteristics curve [AUROC], 0.85; 95% CI, 0.74–0.96). GC-IMS was also moderately accurate at identifying those who subsequently required CPAP (sensitivity/specificity, 0.62/0.80; AUROC, 0.70; 95% CI, 0.53–0.87). CONCLUSIONS: GC-IMS shows promise as both a diagnostic tool and a predictor of prognosis in hospitalized patients with COVID-19 and should be assessed further in larger studies. |
format | Online Article Text |
id | pubmed-9619573 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-96195732022-11-04 Discriminatory Ability of Gas Chromatography–Ion Mobility Spectrometry to Identify Patients Hospitalized With COVID-19 and Predict Prognosis Nazareth, Joshua Pan, Daniel Kim, Jee Whang Leach, Jack Brosnan, James G Ahmed, Adam Brodrick, Emma Bird, Paul Wicaksono, Alfian Daulton, Emma Tang, Julian W Williams, Caroline Haldar, Pranabashis Covington, James A Pareek, Manish Sahota, Amandip Open Forum Infect Dis Major Article BACKGROUND: Rapid diagnostic and prognostic tests for coronavirus disease (COVID-19) are urgently required. We aimed to evaluate the diagnostic and prognostic ability of breath analysis using gas chromatography–ion mobility spectrometry (GC-IMS) in hospitalized patients with COVID-19. METHODS: Between February and May 2021, we took 1 breath sample for analysis using GC-IMS from participants who were admitted to the hospital for COVID-19, participants who were admitted to the hospital for other respiratory infections, and symptom-free controls, at the University Hospitals of Leicester NHS Trust, United Kingdom. Demographic, clinical, and radiological data, including requirement for continuous positive airway pressure (CPAP) ventilation as a marker for severe disease in the COVID-19 group, were collected. RESULTS: A total of 113 participants were recruited into the study. Seventy-two (64%) were diagnosed with COVID-19, 20 (18%) were diagnosed with another respiratory infection, and 21 (19%) were healthy controls. Differentiation between participants with COVID-19 and those with other respiratory tract infections with GC-IMS was highly accurate (sensitivity/specificity, 0.80/0.88; area under the receiver operating characteristics curve [AUROC], 0.85; 95% CI, 0.74–0.96). GC-IMS was also moderately accurate at identifying those who subsequently required CPAP (sensitivity/specificity, 0.62/0.80; AUROC, 0.70; 95% CI, 0.53–0.87). CONCLUSIONS: GC-IMS shows promise as both a diagnostic tool and a predictor of prognosis in hospitalized patients with COVID-19 and should be assessed further in larger studies. Oxford University Press 2022-10-01 /pmc/articles/PMC9619573/ /pubmed/36345428 http://dx.doi.org/10.1093/ofid/ofac509 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Major Article Nazareth, Joshua Pan, Daniel Kim, Jee Whang Leach, Jack Brosnan, James G Ahmed, Adam Brodrick, Emma Bird, Paul Wicaksono, Alfian Daulton, Emma Tang, Julian W Williams, Caroline Haldar, Pranabashis Covington, James A Pareek, Manish Sahota, Amandip Discriminatory Ability of Gas Chromatography–Ion Mobility Spectrometry to Identify Patients Hospitalized With COVID-19 and Predict Prognosis |
title | Discriminatory Ability of Gas Chromatography–Ion Mobility Spectrometry to Identify Patients Hospitalized With COVID-19 and Predict Prognosis |
title_full | Discriminatory Ability of Gas Chromatography–Ion Mobility Spectrometry to Identify Patients Hospitalized With COVID-19 and Predict Prognosis |
title_fullStr | Discriminatory Ability of Gas Chromatography–Ion Mobility Spectrometry to Identify Patients Hospitalized With COVID-19 and Predict Prognosis |
title_full_unstemmed | Discriminatory Ability of Gas Chromatography–Ion Mobility Spectrometry to Identify Patients Hospitalized With COVID-19 and Predict Prognosis |
title_short | Discriminatory Ability of Gas Chromatography–Ion Mobility Spectrometry to Identify Patients Hospitalized With COVID-19 and Predict Prognosis |
title_sort | discriminatory ability of gas chromatography–ion mobility spectrometry to identify patients hospitalized with covid-19 and predict prognosis |
topic | Major Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9619573/ https://www.ncbi.nlm.nih.gov/pubmed/36345428 http://dx.doi.org/10.1093/ofid/ofac509 |
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