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Chemosensory Alterations and Impact on Quality of Life in Persistent Alcohol Drinkers

BACKGROUND: Heavy alcohol consumption-associated chemosensory dysfunction is understudied, and early detection can help predict disease-associated comorbidities, especially those related to four quality of life (QOL) domains (physical, psychological, social and environment). We examined self-reports...

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Autores principales: Agarwal, Khushbu, Luk, Jeremy W, Manza, Peter, McDuffie, Christian, To, Leann, Jaime-Lara, Rosario B, Stangl, Bethany L, Schwandt, Melanie L, Momenan, Reza, Goldman, David, Diazgranados, Nancy, Ramchandani, Vijay A, Joseph, Paule V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9619625/
https://www.ncbi.nlm.nih.gov/pubmed/36208183
http://dx.doi.org/10.1093/alcalc/agac047
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author Agarwal, Khushbu
Luk, Jeremy W
Manza, Peter
McDuffie, Christian
To, Leann
Jaime-Lara, Rosario B
Stangl, Bethany L
Schwandt, Melanie L
Momenan, Reza
Goldman, David
Diazgranados, Nancy
Ramchandani, Vijay A
Joseph, Paule V
author_facet Agarwal, Khushbu
Luk, Jeremy W
Manza, Peter
McDuffie, Christian
To, Leann
Jaime-Lara, Rosario B
Stangl, Bethany L
Schwandt, Melanie L
Momenan, Reza
Goldman, David
Diazgranados, Nancy
Ramchandani, Vijay A
Joseph, Paule V
author_sort Agarwal, Khushbu
collection PubMed
description BACKGROUND: Heavy alcohol consumption-associated chemosensory dysfunction is understudied, and early detection can help predict disease-associated comorbidities, especially those related to four quality of life (QOL) domains (physical, psychological, social and environment). We examined self-reports of chemosensory ability of individuals with different alcohol drinking behaviors and their association with changes in QOL domains. METHODS: Participants (n = 466) were recruited between June 2020 and September 2021 into the NIAAA COVID-19 Pandemic Impact on Alcohol study. Group-based trajectory modeling was used to categorize participants without any known COVID-19 infection into three groups (non-drinkers, moderate drinkers and heavy drinkers) based on their Alcohol Use Disorders Identification Test consumption scores at four different time points (at enrollment, week 4, week 8 and week 12). Linear mixed models were used to examine chemosensory differences between these groups. The associations between chemosensory abilities and QOL were determined in each group. RESULTS: We observed significant impairment in self-reported smell ability of heavy drinking individuals compared to non-drinkers. In contrast, taste ability showed marginal impairment between these groups. There were no significant differences in smell and taste abilities between the moderate and non-drinking groups. Heavy drinkers’ impairment in smell and taste abilities was significantly associated with deterioration in their physical, psychological, social and environmental QOL. CONCLUSION: Persistent heavy drinking was associated with lower chemosensory ability. Heavy drinkers’ reduced smell and taste function and association with poorer QOL indicate that early assessment of chemosensory changes may be crucial in identifying poorer well-being outcomes in heavy drinkers at risk for alcohol use disorder.
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spelling pubmed-96196252022-11-04 Chemosensory Alterations and Impact on Quality of Life in Persistent Alcohol Drinkers Agarwal, Khushbu Luk, Jeremy W Manza, Peter McDuffie, Christian To, Leann Jaime-Lara, Rosario B Stangl, Bethany L Schwandt, Melanie L Momenan, Reza Goldman, David Diazgranados, Nancy Ramchandani, Vijay A Joseph, Paule V Alcohol Alcohol Article BACKGROUND: Heavy alcohol consumption-associated chemosensory dysfunction is understudied, and early detection can help predict disease-associated comorbidities, especially those related to four quality of life (QOL) domains (physical, psychological, social and environment). We examined self-reports of chemosensory ability of individuals with different alcohol drinking behaviors and their association with changes in QOL domains. METHODS: Participants (n = 466) were recruited between June 2020 and September 2021 into the NIAAA COVID-19 Pandemic Impact on Alcohol study. Group-based trajectory modeling was used to categorize participants without any known COVID-19 infection into three groups (non-drinkers, moderate drinkers and heavy drinkers) based on their Alcohol Use Disorders Identification Test consumption scores at four different time points (at enrollment, week 4, week 8 and week 12). Linear mixed models were used to examine chemosensory differences between these groups. The associations between chemosensory abilities and QOL were determined in each group. RESULTS: We observed significant impairment in self-reported smell ability of heavy drinking individuals compared to non-drinkers. In contrast, taste ability showed marginal impairment between these groups. There were no significant differences in smell and taste abilities between the moderate and non-drinking groups. Heavy drinkers’ impairment in smell and taste abilities was significantly associated with deterioration in their physical, psychological, social and environmental QOL. CONCLUSION: Persistent heavy drinking was associated with lower chemosensory ability. Heavy drinkers’ reduced smell and taste function and association with poorer QOL indicate that early assessment of chemosensory changes may be crucial in identifying poorer well-being outcomes in heavy drinkers at risk for alcohol use disorder. Oxford University Press 2022-10-07 /pmc/articles/PMC9619625/ /pubmed/36208183 http://dx.doi.org/10.1093/alcalc/agac047 Text en © The Author(s) 2022. Medical Council on Alcohol and Oxford University Press. All rights reserved. This work is written by US Government employees and is in the public domain in the US.
spellingShingle Article
Agarwal, Khushbu
Luk, Jeremy W
Manza, Peter
McDuffie, Christian
To, Leann
Jaime-Lara, Rosario B
Stangl, Bethany L
Schwandt, Melanie L
Momenan, Reza
Goldman, David
Diazgranados, Nancy
Ramchandani, Vijay A
Joseph, Paule V
Chemosensory Alterations and Impact on Quality of Life in Persistent Alcohol Drinkers
title Chemosensory Alterations and Impact on Quality of Life in Persistent Alcohol Drinkers
title_full Chemosensory Alterations and Impact on Quality of Life in Persistent Alcohol Drinkers
title_fullStr Chemosensory Alterations and Impact on Quality of Life in Persistent Alcohol Drinkers
title_full_unstemmed Chemosensory Alterations and Impact on Quality of Life in Persistent Alcohol Drinkers
title_short Chemosensory Alterations and Impact on Quality of Life in Persistent Alcohol Drinkers
title_sort chemosensory alterations and impact on quality of life in persistent alcohol drinkers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9619625/
https://www.ncbi.nlm.nih.gov/pubmed/36208183
http://dx.doi.org/10.1093/alcalc/agac047
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