Effect of Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine Booster on Human Immunodeficiency Virus Reservoirs and Immune Markers

We investigated effects of the severe acute respiratory syndrome coronavirus 2 (SARV-CoV-2) booster vaccination on human immunodeficiency virus (HIV) reservoir size, immune markers, and host immune responses in people with HIV receiving antiretroviral therapy. Our data suggest that the SARS-CoV-2 bo...

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Autores principales: Rai, M Ali, Shi, Victoria, Kennedy, Brooke D, Justement, Jesse S, Gittens, Kathleen, McCormack, Genevieve, Blazkova, Jana, Moir, Susan, Chun, Tae-Wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9619736/
https://www.ncbi.nlm.nih.gov/pubmed/36345429
http://dx.doi.org/10.1093/ofid/ofac544
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author Rai, M Ali
Shi, Victoria
Kennedy, Brooke D
Justement, Jesse S
Gittens, Kathleen
McCormack, Genevieve
Blazkova, Jana
Moir, Susan
Chun, Tae-Wook
author_facet Rai, M Ali
Shi, Victoria
Kennedy, Brooke D
Justement, Jesse S
Gittens, Kathleen
McCormack, Genevieve
Blazkova, Jana
Moir, Susan
Chun, Tae-Wook
author_sort Rai, M Ali
collection PubMed
description We investigated effects of the severe acute respiratory syndrome coronavirus 2 (SARV-CoV-2) booster vaccination on human immunodeficiency virus (HIV) reservoir size, immune markers, and host immune responses in people with HIV receiving antiretroviral therapy. Our data suggest that the SARS-CoV-2 booster vaccine is not likely to replenish the persistent HIV reservoir nor provide an immunologic environment to facilitate active HIV expression/replication.
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spelling pubmed-96197362022-11-04 Effect of Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine Booster on Human Immunodeficiency Virus Reservoirs and Immune Markers Rai, M Ali Shi, Victoria Kennedy, Brooke D Justement, Jesse S Gittens, Kathleen McCormack, Genevieve Blazkova, Jana Moir, Susan Chun, Tae-Wook Open Forum Infect Dis Brief Report We investigated effects of the severe acute respiratory syndrome coronavirus 2 (SARV-CoV-2) booster vaccination on human immunodeficiency virus (HIV) reservoir size, immune markers, and host immune responses in people with HIV receiving antiretroviral therapy. Our data suggest that the SARS-CoV-2 booster vaccine is not likely to replenish the persistent HIV reservoir nor provide an immunologic environment to facilitate active HIV expression/replication. Oxford University Press 2022-10-17 /pmc/articles/PMC9619736/ /pubmed/36345429 http://dx.doi.org/10.1093/ofid/ofac544 Text en Published by Oxford University Press on behalf of Infectious Diseases Society of America 2022. This work is written by (a) US Government employee(s) and is in the public domain in the US.
spellingShingle Brief Report
Rai, M Ali
Shi, Victoria
Kennedy, Brooke D
Justement, Jesse S
Gittens, Kathleen
McCormack, Genevieve
Blazkova, Jana
Moir, Susan
Chun, Tae-Wook
Effect of Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine Booster on Human Immunodeficiency Virus Reservoirs and Immune Markers
title Effect of Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine Booster on Human Immunodeficiency Virus Reservoirs and Immune Markers
title_full Effect of Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine Booster on Human Immunodeficiency Virus Reservoirs and Immune Markers
title_fullStr Effect of Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine Booster on Human Immunodeficiency Virus Reservoirs and Immune Markers
title_full_unstemmed Effect of Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine Booster on Human Immunodeficiency Virus Reservoirs and Immune Markers
title_short Effect of Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine Booster on Human Immunodeficiency Virus Reservoirs and Immune Markers
title_sort effect of severe acute respiratory syndrome coronavirus 2 vaccine booster on human immunodeficiency virus reservoirs and immune markers
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9619736/
https://www.ncbi.nlm.nih.gov/pubmed/36345429
http://dx.doi.org/10.1093/ofid/ofac544
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