Dynamic Intramolecular Cap for Preserving Metallodrug Integrity—A Case of Catalytic Fluoroquinolones

[Image: see text] A library of eight new fluoroquinolone–nuclease conjugates containing a guanidinoethyl or aminoethyl auxiliary pendant on the cyclen moiety was designed and synthesized to investigate their potential for overcoming the general issue of “metallodrug vulnerability” under physiologica...

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Detalles Bibliográficos
Autores principales: Goldmeier, Moshe N., Khononov, Alina, Belakhov, Valery, Pieńko, Tomasz, Orbach, Noam, Gilad Barzilay, Yuval, Baasov, Timor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9620069/
https://www.ncbi.nlm.nih.gov/pubmed/36219830
http://dx.doi.org/10.1021/acs.jmedchem.2c01302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9620069/
https://www.ncbi.nlm.nih.gov/pubmed/36219830
http://dx.doi.org/10.1021/acs.jmedchem.2c01302

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