Cargando…

Emerging degrader technologies engaging lysosomal pathways

Targeted protein degradation (TPD) provides unprecedented opportunities for drug discovery. While the proteolysis-targeting chimera (PROTAC) technology has already entered clinical trials and changed the landscape of small-molecule drugs, new degrader technologies harnessing alternative degradation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ding, Yu, Xing, Dong, Fei, Yiyan, Lu, Boxun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9620493/ https://www.ncbi.nlm.nih.gov/pubmed/36218065 http://dx.doi.org/10.1039/d2cs00624c

Ejemplares similares

Emerging New Concepts of Degrader Technologies
por: Ding, Yu, et al.
Publicado: (2020)

Targeting mitochondrial degradation by chimeric autophagy-tethering compounds
por: Liu, Zhenqi, et al.
Publicado: (2023)

Emerging Role of the Autophagy/Lysosomal Degradative Pathway in Neurodevelopmental Disorders With Epilepsy
por: Fassio, Anna, et al.
Publicado: (2020)

Lysosome: regulator of lipid degradation pathways
por: Settembre, Carmine, et al.
Publicado: (2014)

Public engagement pathways for emerging GM insect technologies
por: Burgess, Michael M., et al.
Publicado: (2018)

OH radical-initiated single-electron transfer for accelerated degradation via carbocation intermediates
por: Ge, Xiyang, et al.
Publicado: (2023)

Targeting the Autophagy/Lysosomal Degradation Pathway in Parkinson´s Disease
por: Rivero-Ríos, Pilar, et al.
Publicado: (2016)

Comparison of plasma technology for the study of herbicide degradation
por: Bennett, Chonlada, et al.
Publicado: (2023)

Triamterene induces autophagic degradation of lysosome by exacerbating lysosomal integrity
por: Park, Na Yeon, et al.
Publicado: (2021)

BACE2 degradation is mediated by both the proteasome and lysosome pathways
por: Qiu, Kaixin, et al.
Publicado: (2020)

The Autophagy-Lysosomal Pathways and Their Emerging Roles in Modulating Proteostasis in Tumors
por: Dong, Zhen, et al.
Publicado: (2018)

Degradation of lipid droplets by chimeric autophagy-tethering compounds
por: Fu, Yuhua, et al.
Publicado: (2021)

Electrochemical degradation of ciprofloxacin with a Sb-doped SnO(2) electrode: performance, influencing factors and degradation pathways
por: Mu, Yanguang, et al.
Publicado: (2019)

Nitrogen-doped cyan-emissive carbon quantum dots for fluorescence tetracycline detection and lysosome imaging
por: Zhu, Tongtong, et al.
Publicado: (2022)

A self-assembled nanophotosensitizer targets lysosomes and induces lysosomal membrane permeabilization to enhance photodynamic therapy
por: Li, Youyou, et al.
Publicado: (2023)

Influence of solution pH on degradation of atrazine during UV and UV/H(2)O(2) oxidation: kinetics, mechanism, and degradation pathways
por: Liu, Yucan, et al.
Publicado: (2019)

Molecular-level degradation pathways of black phosphorus revealed by mass spectrometry fingerprinting
por: Huang, Xiu, et al.
Publicado: (2023)

Degradation from the outside-in: targeting extracellular and membrane proteins for degradation through the endo-lysosomal pathway
por: Ahn, Green, et al.
Publicado: (2021)

Wnt canonical pathway activates macropinocytosis and lysosomal degradation of extracellular proteins
por: Tejeda-Muñoz, Nydia, et al.
Publicado: (2019)

Lysosomal degradation of GMPPB is associated with limb‐girdle muscular dystrophy type 2T
por: Tian, Wo‐Tu, et al.
Publicado: (2019)

Constructing Productive Engagement: Pre-engagement Tools for Emerging Technologies
por: te Kulve, Haico, et al.
Publicado: (2011)

Rab21 Protein Is Degraded by Both the Ubiquitin-Proteasome Pathway and the Autophagy-Lysosome Pathway
por: Liu, Pinduo, et al.
Publicado: (2022)

Alteration of Dynein Function Affects α-Synuclein Degradation via the Autophagosome-Lysosome Pathway
por: Li, Da, et al.
Publicado: (2013)

TFEB Dependent Autophagy-Lysosomal Pathway: An Emerging Pharmacological Target in Sepsis
por: Liu, Xin, et al.
Publicado: (2021)

The Rab7 effector WDR91 promotes autophagy-lysosome degradation in neurons by regulating lysosome fusion
por: Xing, Ruxiao, et al.
Publicado: (2021)

Persulfate activation by nano zero-valent iron for the degradation of metoprolol in water: influencing factors, degradation pathways and toxicity analysis
por: Gao, Yu-qiong, et al.
Publicado: (2020)

Direct uptake and degradation of DNA by lysosomes
por: Fujiwara, Yuuki, et al.
Publicado: (2013)

Extracellular protein degradation via the lysosome
por: Eldeeb, Mohamed A., et al.
Publicado: (2020)

Targeting Protein Kinases Degradation by PROTACs
por: Yu, Fei, et al.
Publicado: (2021)

An Intralysosomal hsp70 Is Required for a Selective Pathway of Lysosomal Protein Degradation
por: Agarraberes, Fernando A., et al.
Publicado: (1997)

Proteasomal inhibition triggers viral oncoprotein degradation via autophagy-lysosomal pathway
por: Gain, Chandrima, et al.
Publicado: (2020)

Regulation of FN1 degradation by the p62/SQSTM1-dependent autophagy–lysosome pathway in HNSCC
por: Liu, Xinchen, et al.
Publicado: (2020)

Kinetics and pathways of diclofenac degradation by heat-activated persulfate
por: Shi, Hongle, et al.
Publicado: (2019)

Emerging electrochemical energy conversion and storage technologies
por: Badwal, Sukhvinder P. S., et al.
Publicado: (2014)

Major Advances in Emerging Degrader Technologies
por: Luo, Hang, et al.
Publicado: (2022)

Degradation characterization and pathway analysis of chlortetracycline and oxytetracycline in a microbial fuel cell
por: Wang, Ji, et al.
Publicado: (2018)

Sonochemical degradation of pesticides in aqueous solution: investigation on the influence of operating parameters and degradation pathway – a systematic review
por: Pirsaheb, Meghdad, et al.
Publicado: (2020)

Androgens Upregulate Cdc25C Protein by Inhibiting Its Proteasomal and Lysosomal Degradation Pathways
por: Chou, Yu-Wei, et al.
Publicado: (2013)

Rapid and reversible knockdown of endogenous proteins by peptide-directed lysosomal degradation
por: Fan, Xuelai, et al.
Publicado: (2014)

A conserved ubiquitin- and ESCRT-dependent pathway internalizes human lysosomal membrane proteins for degradation
por: Zhang, Weichao, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_6jcjov0u3pe15lm8omdhh62lo4