Annulated carbamates are precursors for the ring contraction of the adamantane framework

We report a protocol for the one-pot two-step synthesis of noradamantane methylene amines. The first step is the triflic acid-promoted decarboxylation of adamantane carbamates, which causes rearrangement of the adamantane framework to form noradamantane iminium salts, which are reduced to amines in...

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Detalles Bibliográficos
Autores principales: Hrdina, Radim, Holovko-Kamoshenkova, Oksana M., Císařová, Ivana, Koucký, Filip, Machalický, Oldřich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9620499/
https://www.ncbi.nlm.nih.gov/pubmed/36349043
http://dx.doi.org/10.1039/d2ra06402b
Descripción
Sumario:We report a protocol for the one-pot two-step synthesis of noradamantane methylene amines. The first step is the triflic acid-promoted decarboxylation of adamantane carbamates, which causes rearrangement of the adamantane framework to form noradamantane iminium salts, which are reduced to amines in the second separate step.

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