Anti-SEZ6L2 antibodies in paraneoplastic cerebellar syndrome: case report and review of the literature

Seizure Related 6 Homolog Like 2 (SEZ6L2) protein has been shown to have implications in neuronal and especially motor function development. In oncology, overexpression of SEZ6L2 serves as a negative prognostic marker in several tumor entities. Recently, few cases of anti-SEZ6L2 antibody mediated ce...

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Autores principales: Kather, Annika, Holtbernd, Florian, Brunkhorst, Robert, Hasan, Dimah, Markewitz, Robert, Wandinger, Klaus-Peter, Wiesmann, Martin, Schulz, Jörg B., Tauber, Simone C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9620611/
https://www.ncbi.nlm.nih.gov/pubmed/36310162
http://dx.doi.org/10.1186/s42466-022-00218-4
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author Kather, Annika
Holtbernd, Florian
Brunkhorst, Robert
Hasan, Dimah
Markewitz, Robert
Wandinger, Klaus-Peter
Wiesmann, Martin
Schulz, Jörg B.
Tauber, Simone C.
author_facet Kather, Annika
Holtbernd, Florian
Brunkhorst, Robert
Hasan, Dimah
Markewitz, Robert
Wandinger, Klaus-Peter
Wiesmann, Martin
Schulz, Jörg B.
Tauber, Simone C.
author_sort Kather, Annika
collection PubMed
description Seizure Related 6 Homolog Like 2 (SEZ6L2) protein has been shown to have implications in neuronal and especially motor function development. In oncology, overexpression of SEZ6L2 serves as a negative prognostic marker in several tumor entities. Recently, few cases of anti-SEZ6L2 antibody mediated cerebellar syndromes were reported. In this article, we present a case of a 70-year-old woman with subacute onset of gait disturbance, dysarthria and limb ataxia. Serum anti-SEZ6L2 antibodies were markedly increased, and further diagnostic workup revealed left sided breast cancer. Neurological symptoms and SEZ6L2 titer significantly improved after curative tumor therapy. This is a very rare and educationally important report of anti-SEZ6L2 autoimmune cerebellar syndrome with a paraneoplastic etiology. Additionally, we performed a review of the current literature for SEZ6L2, focusing on comparing the published cases on autoimmune cerebellar syndrome.
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spelling pubmed-96206112022-11-01 Anti-SEZ6L2 antibodies in paraneoplastic cerebellar syndrome: case report and review of the literature Kather, Annika Holtbernd, Florian Brunkhorst, Robert Hasan, Dimah Markewitz, Robert Wandinger, Klaus-Peter Wiesmann, Martin Schulz, Jörg B. Tauber, Simone C. Neurol Res Pract Review Seizure Related 6 Homolog Like 2 (SEZ6L2) protein has been shown to have implications in neuronal and especially motor function development. In oncology, overexpression of SEZ6L2 serves as a negative prognostic marker in several tumor entities. Recently, few cases of anti-SEZ6L2 antibody mediated cerebellar syndromes were reported. In this article, we present a case of a 70-year-old woman with subacute onset of gait disturbance, dysarthria and limb ataxia. Serum anti-SEZ6L2 antibodies were markedly increased, and further diagnostic workup revealed left sided breast cancer. Neurological symptoms and SEZ6L2 titer significantly improved after curative tumor therapy. This is a very rare and educationally important report of anti-SEZ6L2 autoimmune cerebellar syndrome with a paraneoplastic etiology. Additionally, we performed a review of the current literature for SEZ6L2, focusing on comparing the published cases on autoimmune cerebellar syndrome. BioMed Central 2022-10-31 /pmc/articles/PMC9620611/ /pubmed/36310162 http://dx.doi.org/10.1186/s42466-022-00218-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Kather, Annika
Holtbernd, Florian
Brunkhorst, Robert
Hasan, Dimah
Markewitz, Robert
Wandinger, Klaus-Peter
Wiesmann, Martin
Schulz, Jörg B.
Tauber, Simone C.
Anti-SEZ6L2 antibodies in paraneoplastic cerebellar syndrome: case report and review of the literature
title Anti-SEZ6L2 antibodies in paraneoplastic cerebellar syndrome: case report and review of the literature
title_full Anti-SEZ6L2 antibodies in paraneoplastic cerebellar syndrome: case report and review of the literature
title_fullStr Anti-SEZ6L2 antibodies in paraneoplastic cerebellar syndrome: case report and review of the literature
title_full_unstemmed Anti-SEZ6L2 antibodies in paraneoplastic cerebellar syndrome: case report and review of the literature
title_short Anti-SEZ6L2 antibodies in paraneoplastic cerebellar syndrome: case report and review of the literature
title_sort anti-sez6l2 antibodies in paraneoplastic cerebellar syndrome: case report and review of the literature
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9620611/
https://www.ncbi.nlm.nih.gov/pubmed/36310162
http://dx.doi.org/10.1186/s42466-022-00218-4
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