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Efficacy of domperidone plus renal diet in slowing the progression of chronic kidney disease in dogs with leishmaniosis

BACKGROUND: Chronic kidney disease (CKD) represents the main cause of mortality in dogs with leishmaniosis. Domperidone has recently been reported to improve kidney function in leishmaniotic dogs affected by CKD. Serum symmetric dimethylarginine (sSDMA) has also been shown to be a useful biomarker f...

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Autores principales: Cavalera, Maria Alfonsa, Gernone, Floriana, Uva, Annamaria, Donghia, Rossella, Zizzadoro, Claudia, Zatelli, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9620618/
https://www.ncbi.nlm.nih.gov/pubmed/36316751
http://dx.doi.org/10.1186/s13071-022-05537-8
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author Cavalera, Maria Alfonsa
Gernone, Floriana
Uva, Annamaria
Donghia, Rossella
Zizzadoro, Claudia
Zatelli, Andrea
author_facet Cavalera, Maria Alfonsa
Gernone, Floriana
Uva, Annamaria
Donghia, Rossella
Zizzadoro, Claudia
Zatelli, Andrea
author_sort Cavalera, Maria Alfonsa
collection PubMed
description BACKGROUND: Chronic kidney disease (CKD) represents the main cause of mortality in dogs with leishmaniosis. Domperidone has recently been reported to improve kidney function in leishmaniotic dogs affected by CKD. Serum symmetric dimethylarginine (sSDMA) has also been shown to be a useful biomarker for earlier detection of decreased kidney function when compared to serum creatinine (sCr). This study aimed to assess the efficacy of domperidone plus renal diet in slowing the progression of nephropathy in leishmaniotic dogs with CKD, evaluating sSDMA and sCr as markers of kidney function. METHODS: This study was a therapeutic, prospective, randomized, controlled, 11-month-long field trial. Dogs were recruited if classified as “exposed” to or “infected” with Leishmania infantum and affected by CKD at early stages. After enrolment (T0), dogs were randomized into groups T (treatment) and C (control). All dogs were fed a renal diet and then followed up at 90 (T1), 210 (T2), and 330 (T3) days after inclusion in the study. At T1 and T2, dogs in group T received an oral suspension of domperidone (1 ml/10 kg once a day for up to 28 days). RESULTS: Twenty-two dogs (i.e., n = 12 in group T and n = 10 in group C) completed the study. At T0, the entire population of enrolled dogs presented a mean sSDMA value of 16.5 ± 3.4 μg/dl. At T1 (i.e., after 3 months of renal diet), sSDMA was significantly decreased in both groups, with an sSDMA of 13.1 ± 4.4 μg/dl for the entire population involved. From T1 to T3, sSDMA gradually increased in group C, while remaining stable in group T, which continued to show a significantly lower value of sSDMA at T3 than at T0. Regarding sCr, at T0 and T1, the mean values of the entire population of dogs were 1.1 ± 0.3 and 1.0 ± 0.4 mg/dl, respectively, with no statistical differences between groups T and C. In group T, sCr decreased significantly from T0 to T1, while returning at T3 to values similar to T0. CONCLUSIONS: In this study, domperidone plus renal diet reduced the progression of kidney disease in leishmaniotic dogs affected by CKD. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-96206182022-11-01 Efficacy of domperidone plus renal diet in slowing the progression of chronic kidney disease in dogs with leishmaniosis Cavalera, Maria Alfonsa Gernone, Floriana Uva, Annamaria Donghia, Rossella Zizzadoro, Claudia Zatelli, Andrea Parasit Vectors Research BACKGROUND: Chronic kidney disease (CKD) represents the main cause of mortality in dogs with leishmaniosis. Domperidone has recently been reported to improve kidney function in leishmaniotic dogs affected by CKD. Serum symmetric dimethylarginine (sSDMA) has also been shown to be a useful biomarker for earlier detection of decreased kidney function when compared to serum creatinine (sCr). This study aimed to assess the efficacy of domperidone plus renal diet in slowing the progression of nephropathy in leishmaniotic dogs with CKD, evaluating sSDMA and sCr as markers of kidney function. METHODS: This study was a therapeutic, prospective, randomized, controlled, 11-month-long field trial. Dogs were recruited if classified as “exposed” to or “infected” with Leishmania infantum and affected by CKD at early stages. After enrolment (T0), dogs were randomized into groups T (treatment) and C (control). All dogs were fed a renal diet and then followed up at 90 (T1), 210 (T2), and 330 (T3) days after inclusion in the study. At T1 and T2, dogs in group T received an oral suspension of domperidone (1 ml/10 kg once a day for up to 28 days). RESULTS: Twenty-two dogs (i.e., n = 12 in group T and n = 10 in group C) completed the study. At T0, the entire population of enrolled dogs presented a mean sSDMA value of 16.5 ± 3.4 μg/dl. At T1 (i.e., after 3 months of renal diet), sSDMA was significantly decreased in both groups, with an sSDMA of 13.1 ± 4.4 μg/dl for the entire population involved. From T1 to T3, sSDMA gradually increased in group C, while remaining stable in group T, which continued to show a significantly lower value of sSDMA at T3 than at T0. Regarding sCr, at T0 and T1, the mean values of the entire population of dogs were 1.1 ± 0.3 and 1.0 ± 0.4 mg/dl, respectively, with no statistical differences between groups T and C. In group T, sCr decreased significantly from T0 to T1, while returning at T3 to values similar to T0. CONCLUSIONS: In this study, domperidone plus renal diet reduced the progression of kidney disease in leishmaniotic dogs affected by CKD. GRAPHICAL ABSTRACT: [Image: see text] BioMed Central 2022-10-31 /pmc/articles/PMC9620618/ /pubmed/36316751 http://dx.doi.org/10.1186/s13071-022-05537-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Cavalera, Maria Alfonsa
Gernone, Floriana
Uva, Annamaria
Donghia, Rossella
Zizzadoro, Claudia
Zatelli, Andrea
Efficacy of domperidone plus renal diet in slowing the progression of chronic kidney disease in dogs with leishmaniosis
title Efficacy of domperidone plus renal diet in slowing the progression of chronic kidney disease in dogs with leishmaniosis
title_full Efficacy of domperidone plus renal diet in slowing the progression of chronic kidney disease in dogs with leishmaniosis
title_fullStr Efficacy of domperidone plus renal diet in slowing the progression of chronic kidney disease in dogs with leishmaniosis
title_full_unstemmed Efficacy of domperidone plus renal diet in slowing the progression of chronic kidney disease in dogs with leishmaniosis
title_short Efficacy of domperidone plus renal diet in slowing the progression of chronic kidney disease in dogs with leishmaniosis
title_sort efficacy of domperidone plus renal diet in slowing the progression of chronic kidney disease in dogs with leishmaniosis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9620618/
https://www.ncbi.nlm.nih.gov/pubmed/36316751
http://dx.doi.org/10.1186/s13071-022-05537-8
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