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Correlation between radial peripapillary vascular density and reduced central corneal thickness in glaucoma suspect patients

BACKGROUND: Optical coherence tomography (OCT) angiography (OCTA) provides a quantitative assessment of the microcirculation of the retina and choroid. It may precede the retinal nerve layer (RNFL) and optic disc head defects. Retinal nerve fiber layer defects and reduced central corneal thickness (...

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Autores principales: Lotfy, Ayman, Mattout, Hala Kamal, Fouda, Sameh Mosaad, Hemeda, Sahar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9620628/
https://www.ncbi.nlm.nih.gov/pubmed/36316681
http://dx.doi.org/10.1186/s12886-022-02628-z
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author Lotfy, Ayman
Mattout, Hala Kamal
Fouda, Sameh Mosaad
Hemeda, Sahar
author_facet Lotfy, Ayman
Mattout, Hala Kamal
Fouda, Sameh Mosaad
Hemeda, Sahar
author_sort Lotfy, Ayman
collection PubMed
description BACKGROUND: Optical coherence tomography (OCT) angiography (OCTA) provides a quantitative assessment of the microcirculation of the retina and choroid. It may precede the retinal nerve layer (RNFL) and optic disc head defects. Retinal nerve fiber layer defects and reduced central corneal thickness (CCT) are important parameters in the assessment of a glaucoma suspect patients. The aim of this study is to investigate any possible relationship between the reduced central corneal thickness and the radial peripapillary capillary (RPC) density defect in glaucoma suspect. METHODS: In this cross sectional study, 92 eyes were incorporated. Peripapillary OCT angiography (4.5 mm) and Anterior segment OCT for corneal pachymetry were done. C/D Ratio, thickness of nerve fiber layer, the blood flow indices and central corneal thickness also were evaluated. RESULTS: In eyes of glaucoma suspect patients; a significant positive correlation between CCT and total RPC density was detected (r = 0.38, P < 0.001). A strong positive correlation was also found between total RPC and peripapillary RNFL thickness (r = 0.55, P < 0.001). CONCLUSION: Reduced central corneal thickness and peripapillary capillary density are two screening parameters for glaucoma suspect patients. The radial peripapillary capillary density is a valid diagnostic tool for glaucoma. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12886-022-02628-z.
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spelling pubmed-96206282022-11-01 Correlation between radial peripapillary vascular density and reduced central corneal thickness in glaucoma suspect patients Lotfy, Ayman Mattout, Hala Kamal Fouda, Sameh Mosaad Hemeda, Sahar BMC Ophthalmol Research BACKGROUND: Optical coherence tomography (OCT) angiography (OCTA) provides a quantitative assessment of the microcirculation of the retina and choroid. It may precede the retinal nerve layer (RNFL) and optic disc head defects. Retinal nerve fiber layer defects and reduced central corneal thickness (CCT) are important parameters in the assessment of a glaucoma suspect patients. The aim of this study is to investigate any possible relationship between the reduced central corneal thickness and the radial peripapillary capillary (RPC) density defect in glaucoma suspect. METHODS: In this cross sectional study, 92 eyes were incorporated. Peripapillary OCT angiography (4.5 mm) and Anterior segment OCT for corneal pachymetry were done. C/D Ratio, thickness of nerve fiber layer, the blood flow indices and central corneal thickness also were evaluated. RESULTS: In eyes of glaucoma suspect patients; a significant positive correlation between CCT and total RPC density was detected (r = 0.38, P < 0.001). A strong positive correlation was also found between total RPC and peripapillary RNFL thickness (r = 0.55, P < 0.001). CONCLUSION: Reduced central corneal thickness and peripapillary capillary density are two screening parameters for glaucoma suspect patients. The radial peripapillary capillary density is a valid diagnostic tool for glaucoma. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12886-022-02628-z. BioMed Central 2022-10-31 /pmc/articles/PMC9620628/ /pubmed/36316681 http://dx.doi.org/10.1186/s12886-022-02628-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Lotfy, Ayman
Mattout, Hala Kamal
Fouda, Sameh Mosaad
Hemeda, Sahar
Correlation between radial peripapillary vascular density and reduced central corneal thickness in glaucoma suspect patients
title Correlation between radial peripapillary vascular density and reduced central corneal thickness in glaucoma suspect patients
title_full Correlation between radial peripapillary vascular density and reduced central corneal thickness in glaucoma suspect patients
title_fullStr Correlation between radial peripapillary vascular density and reduced central corneal thickness in glaucoma suspect patients
title_full_unstemmed Correlation between radial peripapillary vascular density and reduced central corneal thickness in glaucoma suspect patients
title_short Correlation between radial peripapillary vascular density and reduced central corneal thickness in glaucoma suspect patients
title_sort correlation between radial peripapillary vascular density and reduced central corneal thickness in glaucoma suspect patients
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9620628/
https://www.ncbi.nlm.nih.gov/pubmed/36316681
http://dx.doi.org/10.1186/s12886-022-02628-z
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