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Sex Differences in Cancer-Specific Survival Are Pronounced during Adolescence and Young Adulthood: A SEER Population-Based Study
Sex differences in cancer survival may be related to hormonal changes during puberty and menopause; therefore, we investigated sex differences in the cancer-specific survival rates of children, adolescents and young adults (AYAs), and older adults with sex-nonspecific cancers. We interrogated the No...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9620934/ https://www.ncbi.nlm.nih.gov/pubmed/36417233 http://dx.doi.org/10.3390/epidemiologia2030029 |
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author | Sultan, Iyad Amarin, Justin Z. Mansour, Razan Sultan, Hala Al-Hussaini, Maysa |
author_facet | Sultan, Iyad Amarin, Justin Z. Mansour, Razan Sultan, Hala Al-Hussaini, Maysa |
author_sort | Sultan, Iyad |
collection | PubMed |
description | Sex differences in cancer survival may be related to hormonal changes during puberty and menopause; therefore, we investigated sex differences in the cancer-specific survival rates of children, adolescents and young adults (AYAs), and older adults with sex-nonspecific cancers. We interrogated the November 2019 submission of the SEER 18 database and included microscopically confirmed cases of first primary malignant tumors. We stratified the dataset into children (<15 years), AYAs (modified; 15–49 years), and older adults (≥50 years). For each age group, we used the Kaplan–Meier method to estimate the sex-stratified 5-year all-site cancer-specific survival probabilities. Of 3,386,276 eligible patients, 45,124 (1.3%) were children, 548,158 (16.2%) were AYAs, and 2,792,994 (82.5%) were older adults. The 5-year all-site cancer-specific survival probabilities were 84.0% (95% CI, 83.5%–84.5%) for boys, 84.8% (95% CI, 84.3%–85.3%) for girls, 70.4% (95% CI, 70.2%–70.6%) for male AYAs, 80.8% (95% CI, 80.6%–81.0%) for female AYAs, 52.0% (95% CI, 51.9%–52.1%) for older adult men, and 52.2% (95% CI, 52.1%–52.3%) for older adult women. The all-site survival rate for female patients with cancer is markedly higher than for male patients with cancer during adolescence and young adulthood, although this difference diminishes in older adulthood. |
format | Online Article Text |
id | pubmed-9620934 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96209342022-11-18 Sex Differences in Cancer-Specific Survival Are Pronounced during Adolescence and Young Adulthood: A SEER Population-Based Study Sultan, Iyad Amarin, Justin Z. Mansour, Razan Sultan, Hala Al-Hussaini, Maysa Epidemiologia (Basel) Article Sex differences in cancer survival may be related to hormonal changes during puberty and menopause; therefore, we investigated sex differences in the cancer-specific survival rates of children, adolescents and young adults (AYAs), and older adults with sex-nonspecific cancers. We interrogated the November 2019 submission of the SEER 18 database and included microscopically confirmed cases of first primary malignant tumors. We stratified the dataset into children (<15 years), AYAs (modified; 15–49 years), and older adults (≥50 years). For each age group, we used the Kaplan–Meier method to estimate the sex-stratified 5-year all-site cancer-specific survival probabilities. Of 3,386,276 eligible patients, 45,124 (1.3%) were children, 548,158 (16.2%) were AYAs, and 2,792,994 (82.5%) were older adults. The 5-year all-site cancer-specific survival probabilities were 84.0% (95% CI, 83.5%–84.5%) for boys, 84.8% (95% CI, 84.3%–85.3%) for girls, 70.4% (95% CI, 70.2%–70.6%) for male AYAs, 80.8% (95% CI, 80.6%–81.0%) for female AYAs, 52.0% (95% CI, 51.9%–52.1%) for older adult men, and 52.2% (95% CI, 52.1%–52.3%) for older adult women. The all-site survival rate for female patients with cancer is markedly higher than for male patients with cancer during adolescence and young adulthood, although this difference diminishes in older adulthood. MDPI 2021-09-01 /pmc/articles/PMC9620934/ /pubmed/36417233 http://dx.doi.org/10.3390/epidemiologia2030029 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sultan, Iyad Amarin, Justin Z. Mansour, Razan Sultan, Hala Al-Hussaini, Maysa Sex Differences in Cancer-Specific Survival Are Pronounced during Adolescence and Young Adulthood: A SEER Population-Based Study |
title | Sex Differences in Cancer-Specific Survival Are Pronounced during Adolescence and Young Adulthood: A SEER Population-Based Study |
title_full | Sex Differences in Cancer-Specific Survival Are Pronounced during Adolescence and Young Adulthood: A SEER Population-Based Study |
title_fullStr | Sex Differences in Cancer-Specific Survival Are Pronounced during Adolescence and Young Adulthood: A SEER Population-Based Study |
title_full_unstemmed | Sex Differences in Cancer-Specific Survival Are Pronounced during Adolescence and Young Adulthood: A SEER Population-Based Study |
title_short | Sex Differences in Cancer-Specific Survival Are Pronounced during Adolescence and Young Adulthood: A SEER Population-Based Study |
title_sort | sex differences in cancer-specific survival are pronounced during adolescence and young adulthood: a seer population-based study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9620934/ https://www.ncbi.nlm.nih.gov/pubmed/36417233 http://dx.doi.org/10.3390/epidemiologia2030029 |
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