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Update on the Pathogenesis, Virulence, and Treatment of Candida auris

Candida auris is an emerging, multidrug resistant fungal pathogen that causes considerable morbidity and mortality. First identified in Japan in 2009, it has since been reported in more than 40 countries. C. auris can persist for long periods on different environmental surfaces as well as the skin....

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Autores principales: Watkins, Richard R., Gowen, Rachael, Lionakis, Michail S., Ghannoum, Mahmoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pathogens and Immunity 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9620957/
https://www.ncbi.nlm.nih.gov/pubmed/36329818
http://dx.doi.org/10.20411/pai.v7i2.535
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author Watkins, Richard R.
Gowen, Rachael
Lionakis, Michail S.
Ghannoum, Mahmoud
author_facet Watkins, Richard R.
Gowen, Rachael
Lionakis, Michail S.
Ghannoum, Mahmoud
author_sort Watkins, Richard R.
collection PubMed
description Candida auris is an emerging, multidrug resistant fungal pathogen that causes considerable morbidity and mortality. First identified in Japan in 2009, it has since been reported in more than 40 countries. C. auris can persist for long periods on different environmental surfaces as well as the skin. Clinical isolates are typically resistant to commonly prescribed antifungal drugs. Increasingly recognized as a cause of infections and outbreaks in nosocomial settings, C. auris is difficult to identify using traditional microbiological methods. One of the main reasons for the ongoing spread of C. auris is the multitude of virulence factors it possesses and uses against its human host that enables fungal persistence on the skin surface. Yet, many of the virulence mechanismsare unknown or remain incompletely understood. In this review, we summarize the evolution of virulence of C. auris, offer recommendations for combating this important human pathogen, and suggest directions for further research.
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spelling pubmed-96209572022-11-02 Update on the Pathogenesis, Virulence, and Treatment of Candida auris Watkins, Richard R. Gowen, Rachael Lionakis, Michail S. Ghannoum, Mahmoud Pathog Immun Review Candida auris is an emerging, multidrug resistant fungal pathogen that causes considerable morbidity and mortality. First identified in Japan in 2009, it has since been reported in more than 40 countries. C. auris can persist for long periods on different environmental surfaces as well as the skin. Clinical isolates are typically resistant to commonly prescribed antifungal drugs. Increasingly recognized as a cause of infections and outbreaks in nosocomial settings, C. auris is difficult to identify using traditional microbiological methods. One of the main reasons for the ongoing spread of C. auris is the multitude of virulence factors it possesses and uses against its human host that enables fungal persistence on the skin surface. Yet, many of the virulence mechanismsare unknown or remain incompletely understood. In this review, we summarize the evolution of virulence of C. auris, offer recommendations for combating this important human pathogen, and suggest directions for further research. Pathogens and Immunity 2022-10-21 /pmc/articles/PMC9620957/ /pubmed/36329818 http://dx.doi.org/10.20411/pai.v7i2.535 Text en © Pathogens and Immunity 2022 https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Review
Watkins, Richard R.
Gowen, Rachael
Lionakis, Michail S.
Ghannoum, Mahmoud
Update on the Pathogenesis, Virulence, and Treatment of Candida auris
title Update on the Pathogenesis, Virulence, and Treatment of Candida auris
title_full Update on the Pathogenesis, Virulence, and Treatment of Candida auris
title_fullStr Update on the Pathogenesis, Virulence, and Treatment of Candida auris
title_full_unstemmed Update on the Pathogenesis, Virulence, and Treatment of Candida auris
title_short Update on the Pathogenesis, Virulence, and Treatment of Candida auris
title_sort update on the pathogenesis, virulence, and treatment of candida auris
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9620957/
https://www.ncbi.nlm.nih.gov/pubmed/36329818
http://dx.doi.org/10.20411/pai.v7i2.535
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