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Update on the Pathogenesis, Virulence, and Treatment of Candida auris
Candida auris is an emerging, multidrug resistant fungal pathogen that causes considerable morbidity and mortality. First identified in Japan in 2009, it has since been reported in more than 40 countries. C. auris can persist for long periods on different environmental surfaces as well as the skin....
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Pathogens and Immunity
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9620957/ https://www.ncbi.nlm.nih.gov/pubmed/36329818 http://dx.doi.org/10.20411/pai.v7i2.535 |
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author | Watkins, Richard R. Gowen, Rachael Lionakis, Michail S. Ghannoum, Mahmoud |
author_facet | Watkins, Richard R. Gowen, Rachael Lionakis, Michail S. Ghannoum, Mahmoud |
author_sort | Watkins, Richard R. |
collection | PubMed |
description | Candida auris is an emerging, multidrug resistant fungal pathogen that causes considerable morbidity and mortality. First identified in Japan in 2009, it has since been reported in more than 40 countries. C. auris can persist for long periods on different environmental surfaces as well as the skin. Clinical isolates are typically resistant to commonly prescribed antifungal drugs. Increasingly recognized as a cause of infections and outbreaks in nosocomial settings, C. auris is difficult to identify using traditional microbiological methods. One of the main reasons for the ongoing spread of C. auris is the multitude of virulence factors it possesses and uses against its human host that enables fungal persistence on the skin surface. Yet, many of the virulence mechanismsare unknown or remain incompletely understood. In this review, we summarize the evolution of virulence of C. auris, offer recommendations for combating this important human pathogen, and suggest directions for further research. |
format | Online Article Text |
id | pubmed-9620957 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Pathogens and Immunity |
record_format | MEDLINE/PubMed |
spelling | pubmed-96209572022-11-02 Update on the Pathogenesis, Virulence, and Treatment of Candida auris Watkins, Richard R. Gowen, Rachael Lionakis, Michail S. Ghannoum, Mahmoud Pathog Immun Review Candida auris is an emerging, multidrug resistant fungal pathogen that causes considerable morbidity and mortality. First identified in Japan in 2009, it has since been reported in more than 40 countries. C. auris can persist for long periods on different environmental surfaces as well as the skin. Clinical isolates are typically resistant to commonly prescribed antifungal drugs. Increasingly recognized as a cause of infections and outbreaks in nosocomial settings, C. auris is difficult to identify using traditional microbiological methods. One of the main reasons for the ongoing spread of C. auris is the multitude of virulence factors it possesses and uses against its human host that enables fungal persistence on the skin surface. Yet, many of the virulence mechanismsare unknown or remain incompletely understood. In this review, we summarize the evolution of virulence of C. auris, offer recommendations for combating this important human pathogen, and suggest directions for further research. Pathogens and Immunity 2022-10-21 /pmc/articles/PMC9620957/ /pubmed/36329818 http://dx.doi.org/10.20411/pai.v7i2.535 Text en © Pathogens and Immunity 2022 https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) |
spellingShingle | Review Watkins, Richard R. Gowen, Rachael Lionakis, Michail S. Ghannoum, Mahmoud Update on the Pathogenesis, Virulence, and Treatment of Candida auris |
title | Update on the Pathogenesis, Virulence, and Treatment of Candida auris |
title_full | Update on the Pathogenesis, Virulence, and Treatment of Candida auris |
title_fullStr | Update on the Pathogenesis, Virulence, and Treatment of Candida auris |
title_full_unstemmed | Update on the Pathogenesis, Virulence, and Treatment of Candida auris |
title_short | Update on the Pathogenesis, Virulence, and Treatment of Candida auris |
title_sort | update on the pathogenesis, virulence, and treatment of candida auris |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9620957/ https://www.ncbi.nlm.nih.gov/pubmed/36329818 http://dx.doi.org/10.20411/pai.v7i2.535 |
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