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Melatonin Treatment for Pediatric Patients with Insomnia: Is There a Place for It?

Sleep is a vital physiological function that is impaired in ranges from 10% in the typically developing pediatric population to over 80% in populations of children with neurodevelopmental disorders and/or psychiatric comorbidities. Pediatric insomnia disorder is an increasing public health concern g...

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Autores principales: Rolling, Julie, Rabot, Juliette, Schroder, Carmen M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621019/
https://www.ncbi.nlm.nih.gov/pubmed/36325278
http://dx.doi.org/10.2147/NSS.S340944
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author Rolling, Julie
Rabot, Juliette
Schroder, Carmen M
author_facet Rolling, Julie
Rabot, Juliette
Schroder, Carmen M
author_sort Rolling, Julie
collection PubMed
description Sleep is a vital physiological function that is impaired in ranges from 10% in the typically developing pediatric population to over 80% in populations of children with neurodevelopmental disorders and/or psychiatric comorbidities. Pediatric insomnia disorder is an increasing public health concern given its negative impact on synaptic plasticity involved in learning and memory consolidation but also on mood regulation, hormonal development and growth, and its significant impact on quality of life of the child, the adolescent and the family. While first-line treatment of pediatric insomnia should include parental education on sleep as well as sleep hygiene measures and behavioural treatment approaches, pharmacological interventions may be necessary if these strategies fail. Melatonin treatment has been increasingly used off-label in pediatric insomnia, given its benign safety profile. This article aims to identify the possible role of melatonin treatment for pediatric insomnia, considering its physiological role in sleep regulation and the differential effects of immediate release (IR) versus prolonged release (PR) melatonin. For the physician dealing with pediatric insomnia, it is particularly important to be able to distinguish treatment rationales implying different dosages and times of treatment intake. Finally, we discuss the benefit–risk ratio for melatonin treatment in different pediatric populations, ranging from the general pediatric population to children with different types of neurodevelopmental disorders, such as autism spectrum disorder or ADHD.
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spelling pubmed-96210192022-11-01 Melatonin Treatment for Pediatric Patients with Insomnia: Is There a Place for It? Rolling, Julie Rabot, Juliette Schroder, Carmen M Nat Sci Sleep Review Sleep is a vital physiological function that is impaired in ranges from 10% in the typically developing pediatric population to over 80% in populations of children with neurodevelopmental disorders and/or psychiatric comorbidities. Pediatric insomnia disorder is an increasing public health concern given its negative impact on synaptic plasticity involved in learning and memory consolidation but also on mood regulation, hormonal development and growth, and its significant impact on quality of life of the child, the adolescent and the family. While first-line treatment of pediatric insomnia should include parental education on sleep as well as sleep hygiene measures and behavioural treatment approaches, pharmacological interventions may be necessary if these strategies fail. Melatonin treatment has been increasingly used off-label in pediatric insomnia, given its benign safety profile. This article aims to identify the possible role of melatonin treatment for pediatric insomnia, considering its physiological role in sleep regulation and the differential effects of immediate release (IR) versus prolonged release (PR) melatonin. For the physician dealing with pediatric insomnia, it is particularly important to be able to distinguish treatment rationales implying different dosages and times of treatment intake. Finally, we discuss the benefit–risk ratio for melatonin treatment in different pediatric populations, ranging from the general pediatric population to children with different types of neurodevelopmental disorders, such as autism spectrum disorder or ADHD. Dove 2022-10-27 /pmc/articles/PMC9621019/ /pubmed/36325278 http://dx.doi.org/10.2147/NSS.S340944 Text en © 2022 Rolling et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Rolling, Julie
Rabot, Juliette
Schroder, Carmen M
Melatonin Treatment for Pediatric Patients with Insomnia: Is There a Place for It?
title Melatonin Treatment for Pediatric Patients with Insomnia: Is There a Place for It?
title_full Melatonin Treatment for Pediatric Patients with Insomnia: Is There a Place for It?
title_fullStr Melatonin Treatment for Pediatric Patients with Insomnia: Is There a Place for It?
title_full_unstemmed Melatonin Treatment for Pediatric Patients with Insomnia: Is There a Place for It?
title_short Melatonin Treatment for Pediatric Patients with Insomnia: Is There a Place for It?
title_sort melatonin treatment for pediatric patients with insomnia: is there a place for it?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621019/
https://www.ncbi.nlm.nih.gov/pubmed/36325278
http://dx.doi.org/10.2147/NSS.S340944
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