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An observational investigation of the faical microbiota and metabonome of gastrostomy fed children, on blended and formula diets

Gastrostomy fed children traditionally have a Formulae diet (FD), which fulfills nutritional requirements; however, many families are adopting Blended diets (BD), which are what the whole family would eat. We undertook an observational investigation of the colonic microbiota and metabonome in a smal...

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Autores principales: Marchesi, Julian R., Allen, Sophie, Scott, Emma, Jenkins, Huw, Sadlier, Claire, Thomas, Sian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621064/
https://www.ncbi.nlm.nih.gov/pubmed/36284401
http://dx.doi.org/10.1080/19490976.2022.2138661
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author Marchesi, Julian R.
Allen, Sophie
Scott, Emma
Jenkins, Huw
Sadlier, Claire
Thomas, Sian
author_facet Marchesi, Julian R.
Allen, Sophie
Scott, Emma
Jenkins, Huw
Sadlier, Claire
Thomas, Sian
author_sort Marchesi, Julian R.
collection PubMed
description Gastrostomy fed children traditionally have a Formulae diet (FD), which fulfills nutritional requirements; however, many families are adopting Blended diets (BD), which are what the whole family would eat. We undertook an observational investigation of the colonic microbiota and metabonome in a small group of gastrostomy fed children, who were either on an FD or BD, and compared, where possible to their siblings (17 FD, 28 BD, 19 HS). There was no increase in complications in tube blockage or infection rates, but a significant improvement in the prevalence of bowel problems, a reduction in medication and an increase in quality of life. Metataxonomic analysis showed that the FD group was significantly different to the Sibling group, and that families did not cluster together. Whole sample metabonomics showed no differences between groups; however, univariate analysis of biologically important metabolites did differ. Changing to a BD resulted in no increase in complications or risks, but improved the overall quality of life for the children and families.
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spelling pubmed-96210642022-11-01 An observational investigation of the faical microbiota and metabonome of gastrostomy fed children, on blended and formula diets Marchesi, Julian R. Allen, Sophie Scott, Emma Jenkins, Huw Sadlier, Claire Thomas, Sian Gut Microbes Research Paper Gastrostomy fed children traditionally have a Formulae diet (FD), which fulfills nutritional requirements; however, many families are adopting Blended diets (BD), which are what the whole family would eat. We undertook an observational investigation of the colonic microbiota and metabonome in a small group of gastrostomy fed children, who were either on an FD or BD, and compared, where possible to their siblings (17 FD, 28 BD, 19 HS). There was no increase in complications in tube blockage or infection rates, but a significant improvement in the prevalence of bowel problems, a reduction in medication and an increase in quality of life. Metataxonomic analysis showed that the FD group was significantly different to the Sibling group, and that families did not cluster together. Whole sample metabonomics showed no differences between groups; however, univariate analysis of biologically important metabolites did differ. Changing to a BD resulted in no increase in complications or risks, but improved the overall quality of life for the children and families. Taylor & Francis 2022-10-25 /pmc/articles/PMC9621064/ /pubmed/36284401 http://dx.doi.org/10.1080/19490976.2022.2138661 Text en © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Marchesi, Julian R.
Allen, Sophie
Scott, Emma
Jenkins, Huw
Sadlier, Claire
Thomas, Sian
An observational investigation of the faical microbiota and metabonome of gastrostomy fed children, on blended and formula diets
title An observational investigation of the faical microbiota and metabonome of gastrostomy fed children, on blended and formula diets
title_full An observational investigation of the faical microbiota and metabonome of gastrostomy fed children, on blended and formula diets
title_fullStr An observational investigation of the faical microbiota and metabonome of gastrostomy fed children, on blended and formula diets
title_full_unstemmed An observational investigation of the faical microbiota and metabonome of gastrostomy fed children, on blended and formula diets
title_short An observational investigation of the faical microbiota and metabonome of gastrostomy fed children, on blended and formula diets
title_sort observational investigation of the faical microbiota and metabonome of gastrostomy fed children, on blended and formula diets
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621064/
https://www.ncbi.nlm.nih.gov/pubmed/36284401
http://dx.doi.org/10.1080/19490976.2022.2138661
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