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An observational investigation of the faical microbiota and metabonome of gastrostomy fed children, on blended and formula diets
Gastrostomy fed children traditionally have a Formulae diet (FD), which fulfills nutritional requirements; however, many families are adopting Blended diets (BD), which are what the whole family would eat. We undertook an observational investigation of the colonic microbiota and metabonome in a smal...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621064/ https://www.ncbi.nlm.nih.gov/pubmed/36284401 http://dx.doi.org/10.1080/19490976.2022.2138661 |
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author | Marchesi, Julian R. Allen, Sophie Scott, Emma Jenkins, Huw Sadlier, Claire Thomas, Sian |
author_facet | Marchesi, Julian R. Allen, Sophie Scott, Emma Jenkins, Huw Sadlier, Claire Thomas, Sian |
author_sort | Marchesi, Julian R. |
collection | PubMed |
description | Gastrostomy fed children traditionally have a Formulae diet (FD), which fulfills nutritional requirements; however, many families are adopting Blended diets (BD), which are what the whole family would eat. We undertook an observational investigation of the colonic microbiota and metabonome in a small group of gastrostomy fed children, who were either on an FD or BD, and compared, where possible to their siblings (17 FD, 28 BD, 19 HS). There was no increase in complications in tube blockage or infection rates, but a significant improvement in the prevalence of bowel problems, a reduction in medication and an increase in quality of life. Metataxonomic analysis showed that the FD group was significantly different to the Sibling group, and that families did not cluster together. Whole sample metabonomics showed no differences between groups; however, univariate analysis of biologically important metabolites did differ. Changing to a BD resulted in no increase in complications or risks, but improved the overall quality of life for the children and families. |
format | Online Article Text |
id | pubmed-9621064 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-96210642022-11-01 An observational investigation of the faical microbiota and metabonome of gastrostomy fed children, on blended and formula diets Marchesi, Julian R. Allen, Sophie Scott, Emma Jenkins, Huw Sadlier, Claire Thomas, Sian Gut Microbes Research Paper Gastrostomy fed children traditionally have a Formulae diet (FD), which fulfills nutritional requirements; however, many families are adopting Blended diets (BD), which are what the whole family would eat. We undertook an observational investigation of the colonic microbiota and metabonome in a small group of gastrostomy fed children, who were either on an FD or BD, and compared, where possible to their siblings (17 FD, 28 BD, 19 HS). There was no increase in complications in tube blockage or infection rates, but a significant improvement in the prevalence of bowel problems, a reduction in medication and an increase in quality of life. Metataxonomic analysis showed that the FD group was significantly different to the Sibling group, and that families did not cluster together. Whole sample metabonomics showed no differences between groups; however, univariate analysis of biologically important metabolites did differ. Changing to a BD resulted in no increase in complications or risks, but improved the overall quality of life for the children and families. Taylor & Francis 2022-10-25 /pmc/articles/PMC9621064/ /pubmed/36284401 http://dx.doi.org/10.1080/19490976.2022.2138661 Text en © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Paper Marchesi, Julian R. Allen, Sophie Scott, Emma Jenkins, Huw Sadlier, Claire Thomas, Sian An observational investigation of the faical microbiota and metabonome of gastrostomy fed children, on blended and formula diets |
title | An observational investigation of the faical microbiota and metabonome of gastrostomy fed children, on blended and formula diets |
title_full | An observational investigation of the faical microbiota and metabonome of gastrostomy fed children, on blended and formula diets |
title_fullStr | An observational investigation of the faical microbiota and metabonome of gastrostomy fed children, on blended and formula diets |
title_full_unstemmed | An observational investigation of the faical microbiota and metabonome of gastrostomy fed children, on blended and formula diets |
title_short | An observational investigation of the faical microbiota and metabonome of gastrostomy fed children, on blended and formula diets |
title_sort | observational investigation of the faical microbiota and metabonome of gastrostomy fed children, on blended and formula diets |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621064/ https://www.ncbi.nlm.nih.gov/pubmed/36284401 http://dx.doi.org/10.1080/19490976.2022.2138661 |
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