Haploinsufficiency of CYP8B1 associates with increased insulin sensitivity in humans

BACKGROUND: Cytochrome P450 family 8 subfamily B member 1 (CYP8B1) generates 12α-hydroxylated bile acids (BAs) that are associated with insulin resistance in humans. METHODS: To determine whether reduced CYP8B1 activity improves insulin sensitivity, we sequenced CYP8B1 in individuals without diabete...

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Detalles Bibliográficos
Autores principales: Zhong, Shiqi, Chèvre, Raphael, Castaño Mayan, David, Corlianò, Maria, Cochran, Blake J., Sem, Kai Ping, van Dijk, Theo H., Peng, Jianhe, Tan, Liang Juin, Hartimath, Siddesh V., Ramasamy, Boominathan, Cheng, Peter, Groen, Albert K., Kuipers, Folkert, Goggi, Julian L., Drum, Chester, van Dam, Rob M., Tan, Ru San, Rye, Kerry-Anne, Hayden, Michael R., Cheng, Ching-Yu, Chacko, Shaji, Flannick, Jason, Sim, Xueling, Tan, Hong Chang, Singaraja, Roshni R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Clinical Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621133/
https://www.ncbi.nlm.nih.gov/pubmed/36107630
http://dx.doi.org/10.1172/JCI152961

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