CD200 ectodomain shedding into the tumor microenvironment leads to NK cell dysfunction and apoptosis

The basis of immune evasion, a hallmark of cancer, can differ even when cancers arise from one cell type such as in the human skin keratinocyte carcinomas: basal and squamous cell carcinoma. Here we showed that the basal cell carcinoma tumor–initiating cell surface protein CD200, through ectodomain...

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Detalles Bibliográficos
Autores principales: Morgan, Huw J., Rees, Elise, Lanfredini, Simone, Powell, Kate A., Gore, Jasmine, Gibbs, Alex, Lovatt, Charlotte, Davies, Gemma E., Olivero, Carlotta, Shorning, Boris Y., Tornillo, Giusy, Tonks, Alex, Darley, Richard, Wang, Eddie C.Y., Patel, Girish K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621138/
https://www.ncbi.nlm.nih.gov/pubmed/36074574
http://dx.doi.org/10.1172/JCI150750

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