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Identification of CKD, bedridden history and cancer as higher-risk comorbidities and their impact on prognosis of hospitalized Omicron patients: a multi-centre cohort study

To further describe the effect of the “fragile population” and their “higher-risk” comorbidities on prognosis among hospitalized Omicron patients, this observational cohort study enrolled hospitalized patients confirmed with SARS-CoV-2 during the 2022 Omicron wave in Shanghai, China. The primary out...

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Autores principales: Chen, Xiaohua, Wang, Hongyu, Ai, Jingwen, Shen, Leer, Lin, Ke, Yuan, Guanmin, Sheng, Xiaohua, Jin, Xia, Deng, Zhifeng, Xu, Jie, Lu, Guanzhu, Chen, Shunjie, Cai, Jianpeng, Zhang, Yi, Zhang, Haocheng, Wang, Sen, Zhang, Wenhong, Fan, Cunyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621241/
https://www.ncbi.nlm.nih.gov/pubmed/36106526
http://dx.doi.org/10.1080/22221751.2022.2122581
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author Chen, Xiaohua
Wang, Hongyu
Ai, Jingwen
Shen, Leer
Lin, Ke
Yuan, Guanmin
Sheng, Xiaohua
Jin, Xia
Deng, Zhifeng
Xu, Jie
Lu, Guanzhu
Chen, Shunjie
Cai, Jianpeng
Zhang, Yi
Zhang, Haocheng
Wang, Sen
Zhang, Wenhong
Fan, Cunyi
author_facet Chen, Xiaohua
Wang, Hongyu
Ai, Jingwen
Shen, Leer
Lin, Ke
Yuan, Guanmin
Sheng, Xiaohua
Jin, Xia
Deng, Zhifeng
Xu, Jie
Lu, Guanzhu
Chen, Shunjie
Cai, Jianpeng
Zhang, Yi
Zhang, Haocheng
Wang, Sen
Zhang, Wenhong
Fan, Cunyi
author_sort Chen, Xiaohua
collection PubMed
description To further describe the effect of the “fragile population” and their “higher-risk” comorbidities on prognosis among hospitalized Omicron patients, this observational cohort study enrolled hospitalized patients confirmed with SARS-CoV-2 during the 2022 Omicron wave in Shanghai, China. The primary outcome was progression to severe or critical cases. The secondary outcome was viral shedding time from the first positive SARS-CoV-2 detection. A total of 847 participants were enrolled, most of whom featured as advanced age (>70 years old: 30.34%), not fully vaccinated (55.84%), combined with at least 1 comorbidity (65.41%). Multivariate cox regression suggested age >70 years old (aHR[95%CI] 0.78[0.61–0.99]), chronic kidney disease (CKD) stage 4–5 (aHR[95%CI] 0.61[0.46–0.80]), heart conditions (aHR[95%CI] 0.76[0.60–0.97]) would elongate viral shedding time and fully/booster vaccination (aHR[95%CI] 1.4 [1.14–1.72]) would shorten this duration. Multivariate logistic regression suggested CKD stage 4–5 (aHR[95%CI] 3.21[1.45–7.27]), cancer (aHR[95%CI] 9.52[4.19–22.61]), and long-term bedridden status (aHR[95%CI] 4.94[2.36–10.44]) were the “higher” risk factor compared with the elderly, heart conditions, metabolic disorders, isolated hypertension, etc. for severity while female (aHR[95%CI] 0.34[0.16–0.68]) and fully/booster Vaccination (aHR[95%CI] 0.35[0.12–0.87]) could provide protection from illness progression. CKD stage 4–5, cancer and long-term bedridden history were “higher-risk” factors among hospitalized Omicron patients for severity progression while full vaccination could provide protection from illness progression.
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spelling pubmed-96212412022-11-01 Identification of CKD, bedridden history and cancer as higher-risk comorbidities and their impact on prognosis of hospitalized Omicron patients: a multi-centre cohort study Chen, Xiaohua Wang, Hongyu Ai, Jingwen Shen, Leer Lin, Ke Yuan, Guanmin Sheng, Xiaohua Jin, Xia Deng, Zhifeng Xu, Jie Lu, Guanzhu Chen, Shunjie Cai, Jianpeng Zhang, Yi Zhang, Haocheng Wang, Sen Zhang, Wenhong Fan, Cunyi Emerg Microbes Infect Coronaviruses To further describe the effect of the “fragile population” and their “higher-risk” comorbidities on prognosis among hospitalized Omicron patients, this observational cohort study enrolled hospitalized patients confirmed with SARS-CoV-2 during the 2022 Omicron wave in Shanghai, China. The primary outcome was progression to severe or critical cases. The secondary outcome was viral shedding time from the first positive SARS-CoV-2 detection. A total of 847 participants were enrolled, most of whom featured as advanced age (>70 years old: 30.34%), not fully vaccinated (55.84%), combined with at least 1 comorbidity (65.41%). Multivariate cox regression suggested age >70 years old (aHR[95%CI] 0.78[0.61–0.99]), chronic kidney disease (CKD) stage 4–5 (aHR[95%CI] 0.61[0.46–0.80]), heart conditions (aHR[95%CI] 0.76[0.60–0.97]) would elongate viral shedding time and fully/booster vaccination (aHR[95%CI] 1.4 [1.14–1.72]) would shorten this duration. Multivariate logistic regression suggested CKD stage 4–5 (aHR[95%CI] 3.21[1.45–7.27]), cancer (aHR[95%CI] 9.52[4.19–22.61]), and long-term bedridden status (aHR[95%CI] 4.94[2.36–10.44]) were the “higher” risk factor compared with the elderly, heart conditions, metabolic disorders, isolated hypertension, etc. for severity while female (aHR[95%CI] 0.34[0.16–0.68]) and fully/booster Vaccination (aHR[95%CI] 0.35[0.12–0.87]) could provide protection from illness progression. CKD stage 4–5, cancer and long-term bedridden history were “higher-risk” factors among hospitalized Omicron patients for severity progression while full vaccination could provide protection from illness progression. Taylor & Francis 2022-10-26 /pmc/articles/PMC9621241/ /pubmed/36106526 http://dx.doi.org/10.1080/22221751.2022.2122581 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Coronaviruses
Chen, Xiaohua
Wang, Hongyu
Ai, Jingwen
Shen, Leer
Lin, Ke
Yuan, Guanmin
Sheng, Xiaohua
Jin, Xia
Deng, Zhifeng
Xu, Jie
Lu, Guanzhu
Chen, Shunjie
Cai, Jianpeng
Zhang, Yi
Zhang, Haocheng
Wang, Sen
Zhang, Wenhong
Fan, Cunyi
Identification of CKD, bedridden history and cancer as higher-risk comorbidities and their impact on prognosis of hospitalized Omicron patients: a multi-centre cohort study
title Identification of CKD, bedridden history and cancer as higher-risk comorbidities and their impact on prognosis of hospitalized Omicron patients: a multi-centre cohort study
title_full Identification of CKD, bedridden history and cancer as higher-risk comorbidities and their impact on prognosis of hospitalized Omicron patients: a multi-centre cohort study
title_fullStr Identification of CKD, bedridden history and cancer as higher-risk comorbidities and their impact on prognosis of hospitalized Omicron patients: a multi-centre cohort study
title_full_unstemmed Identification of CKD, bedridden history and cancer as higher-risk comorbidities and their impact on prognosis of hospitalized Omicron patients: a multi-centre cohort study
title_short Identification of CKD, bedridden history and cancer as higher-risk comorbidities and their impact on prognosis of hospitalized Omicron patients: a multi-centre cohort study
title_sort identification of ckd, bedridden history and cancer as higher-risk comorbidities and their impact on prognosis of hospitalized omicron patients: a multi-centre cohort study
topic Coronaviruses
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621241/
https://www.ncbi.nlm.nih.gov/pubmed/36106526
http://dx.doi.org/10.1080/22221751.2022.2122581
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