A new small molecule DHODH-inhibitor [KIO-100 (PP-001)] targeting activated T cells for intraocular treatment of uveitis — A phase I clinical trial

Uveitis is a T cell-mediated, intraocular inflammatory disease and one of the main causes of blindness in industrialized countries. There is a high unmet need for new immunomodulatory, steroid-sparing therapies, since only ciclosporin A and a single TNF-α-blocker are approved for non-infectious uvei...

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Detalles Bibliográficos
Autores principales: Thurau, Stephan, Deuter, Christoph M. E., Heiligenhaus, Arnd, Pleyer, Uwe, Van Calster, Joachim, Barisani-Asenbauer, Talin, Obermayr, Franz, Sperl, Stefan, Seda-Zehetner, Romana, Wildner, Gerhild
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621317/
https://www.ncbi.nlm.nih.gov/pubmed/36325389
http://dx.doi.org/10.3389/fmed.2022.1023224

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