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Neurofilament Light Chain Levels Are Predictive of Clinical Conversion in Radiologically Isolated Syndrome

BACKGROUND AND OBJECTIVES: To evaluate the predictive value of serum neurofilament light chain (sNfL) and CSF NfL (cNfL) in patients with radiologically isolated syndrome (RIS) for evidence of disease activity (EDA) and clinical conversion (CC). METHODS: sNfL and cNfL were measured at RIS diagnosis...

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Autores principales: Rival, Manon, Thouvenot, Eric, Du Trieu de Terdonck, Lucile, Laurent-Chabalier, Sabine, Demattei, Christophe, Uygunoglu, Ugur, Castelnovo, Giovanni, Cohen, Mikael, Okuda, Darin T., Kantarci, Orhun H., Pelletier, Daniel, Azevedo, Christina, Marin, Philippe, Lehmann, Sylvain, Siva, Aksel, Mura, Thibault, Lebrun-Frenay, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621336/
https://www.ncbi.nlm.nih.gov/pubmed/36280258
http://dx.doi.org/10.1212/NXI.0000000000200044
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author Rival, Manon
Thouvenot, Eric
Du Trieu de Terdonck, Lucile
Laurent-Chabalier, Sabine
Demattei, Christophe
Uygunoglu, Ugur
Castelnovo, Giovanni
Cohen, Mikael
Okuda, Darin T.
Kantarci, Orhun H.
Pelletier, Daniel
Azevedo, Christina
Marin, Philippe
Lehmann, Sylvain
Siva, Aksel
Mura, Thibault
Lebrun-Frenay, Christine
author_facet Rival, Manon
Thouvenot, Eric
Du Trieu de Terdonck, Lucile
Laurent-Chabalier, Sabine
Demattei, Christophe
Uygunoglu, Ugur
Castelnovo, Giovanni
Cohen, Mikael
Okuda, Darin T.
Kantarci, Orhun H.
Pelletier, Daniel
Azevedo, Christina
Marin, Philippe
Lehmann, Sylvain
Siva, Aksel
Mura, Thibault
Lebrun-Frenay, Christine
author_sort Rival, Manon
collection PubMed
description BACKGROUND AND OBJECTIVES: To evaluate the predictive value of serum neurofilament light chain (sNfL) and CSF NfL (cNfL) in patients with radiologically isolated syndrome (RIS) for evidence of disease activity (EDA) and clinical conversion (CC). METHODS: sNfL and cNfL were measured at RIS diagnosis by single-molecule array (Simoa). The risk of EDA and CC according to sNfL and cNfL was evaluated using the Kaplan-Meier analysis and multivariate Cox regression models including age, spinal cord (SC) or infratentorial lesions, oligoclonal bands, CSF chitinase 3–like protein 1, and CSF white blood cells. RESULTS: Sixty-one patients with RIS were included. At diagnosis, sNfL and cNfL were correlated (Spearman r = 0.78, p < 0.001). During follow-up, 47 patients with RIS showed EDA and 36 patients showed CC (median time 12.6 months, 1–86). When compared with low levels, medium and high cNfL (>260 pg/mL) and sNfL (>5.0 pg/mL) levels were predictive of EDA (log rank, p < 0.01 and p = 0.02, respectively). Medium-high cNfL levels were predictive of CC (log rank, p < 0.01). In Cox regression models, cNfL and sNfL were independent factors of EDA, while SC lesions, cNfL, and sNfL were independent factors of CC. DISCUSSION: cNfL >260 pg/mL and sNfL >5.0 pg/mL at diagnosis are independent predictive factors of EDA and CC in RIS. Although cNfL predicts disease activity better, sNfL is more accessible than cNfL and can be considered when a lumbar puncture is not performed. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that in people with radiologic isolated syndrome (RIS), initial serum and CSF NfL levels are associated with subsequent evidence of disease activity or clinical conversion.
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spelling pubmed-96213362022-11-01 Neurofilament Light Chain Levels Are Predictive of Clinical Conversion in Radiologically Isolated Syndrome Rival, Manon Thouvenot, Eric Du Trieu de Terdonck, Lucile Laurent-Chabalier, Sabine Demattei, Christophe Uygunoglu, Ugur Castelnovo, Giovanni Cohen, Mikael Okuda, Darin T. Kantarci, Orhun H. Pelletier, Daniel Azevedo, Christina Marin, Philippe Lehmann, Sylvain Siva, Aksel Mura, Thibault Lebrun-Frenay, Christine Neurol Neuroimmunol Neuroinflamm Research Article BACKGROUND AND OBJECTIVES: To evaluate the predictive value of serum neurofilament light chain (sNfL) and CSF NfL (cNfL) in patients with radiologically isolated syndrome (RIS) for evidence of disease activity (EDA) and clinical conversion (CC). METHODS: sNfL and cNfL were measured at RIS diagnosis by single-molecule array (Simoa). The risk of EDA and CC according to sNfL and cNfL was evaluated using the Kaplan-Meier analysis and multivariate Cox regression models including age, spinal cord (SC) or infratentorial lesions, oligoclonal bands, CSF chitinase 3–like protein 1, and CSF white blood cells. RESULTS: Sixty-one patients with RIS were included. At diagnosis, sNfL and cNfL were correlated (Spearman r = 0.78, p < 0.001). During follow-up, 47 patients with RIS showed EDA and 36 patients showed CC (median time 12.6 months, 1–86). When compared with low levels, medium and high cNfL (>260 pg/mL) and sNfL (>5.0 pg/mL) levels were predictive of EDA (log rank, p < 0.01 and p = 0.02, respectively). Medium-high cNfL levels were predictive of CC (log rank, p < 0.01). In Cox regression models, cNfL and sNfL were independent factors of EDA, while SC lesions, cNfL, and sNfL were independent factors of CC. DISCUSSION: cNfL >260 pg/mL and sNfL >5.0 pg/mL at diagnosis are independent predictive factors of EDA and CC in RIS. Although cNfL predicts disease activity better, sNfL is more accessible than cNfL and can be considered when a lumbar puncture is not performed. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that in people with radiologic isolated syndrome (RIS), initial serum and CSF NfL levels are associated with subsequent evidence of disease activity or clinical conversion. Lippincott Williams & Wilkins 2022-10-24 /pmc/articles/PMC9621336/ /pubmed/36280258 http://dx.doi.org/10.1212/NXI.0000000000200044 Text en Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Research Article
Rival, Manon
Thouvenot, Eric
Du Trieu de Terdonck, Lucile
Laurent-Chabalier, Sabine
Demattei, Christophe
Uygunoglu, Ugur
Castelnovo, Giovanni
Cohen, Mikael
Okuda, Darin T.
Kantarci, Orhun H.
Pelletier, Daniel
Azevedo, Christina
Marin, Philippe
Lehmann, Sylvain
Siva, Aksel
Mura, Thibault
Lebrun-Frenay, Christine
Neurofilament Light Chain Levels Are Predictive of Clinical Conversion in Radiologically Isolated Syndrome
title Neurofilament Light Chain Levels Are Predictive of Clinical Conversion in Radiologically Isolated Syndrome
title_full Neurofilament Light Chain Levels Are Predictive of Clinical Conversion in Radiologically Isolated Syndrome
title_fullStr Neurofilament Light Chain Levels Are Predictive of Clinical Conversion in Radiologically Isolated Syndrome
title_full_unstemmed Neurofilament Light Chain Levels Are Predictive of Clinical Conversion in Radiologically Isolated Syndrome
title_short Neurofilament Light Chain Levels Are Predictive of Clinical Conversion in Radiologically Isolated Syndrome
title_sort neurofilament light chain levels are predictive of clinical conversion in radiologically isolated syndrome
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621336/
https://www.ncbi.nlm.nih.gov/pubmed/36280258
http://dx.doi.org/10.1212/NXI.0000000000200044
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