Scaffolding protein functional sites using deep learning

The binding and catalytic functions of proteins are generally mediated by a small number of functional residues held in place by the overall protein structure. We describe deep learning approaches for scaffolding such functional sites without needing to pre-specify the fold or secondary structure of...

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Detalles Bibliográficos
Autores principales: Wang, Jue, Lisanza, Sidney, Juergens, David, Tischer, Doug, Watson, Joseph L., Castro, Karla M., Ragotte, Robert, Saragovi, Amijai, Milles, Lukas F., Baek, Minkyung, Anishchenko, Ivan, Yang, Wei, Hicks, Derrick R., Expòsit, Marc, Schlichthaerle, Thomas, Chun, Jung-Ho, Dauparas, Justas, Bennett, Nathaniel, Wicky, Basile I. M., Muenks, Andrew, DiMaio, Frank, Correia, Bruno, Ovchinnikov, Sergey, Baker, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621694/
https://www.ncbi.nlm.nih.gov/pubmed/35862514
http://dx.doi.org/10.1126/science.abn2100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621694/
https://www.ncbi.nlm.nih.gov/pubmed/35862514
http://dx.doi.org/10.1126/science.abn2100

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