Granulomatosis With Polyangiitis in Untreated Graves’ Disease: A Rare Event

Antithyroid medications can cause antineutrophil cytoplasmic antibody (ANCA) vasculitis. However, no literature in English describes the coexistence of granulomatosis with polyangiitis (GPA) and untreated Graves’ disease. We present a 19-year-old female with thyroid storm and additional complaints o...

Descripción completa

Detalles Bibliográficos
Autores principales: Moosa, Syed Ahmad, Mendez, Christian M, Sanchez, Zuleyka, Cabrera, Luis Mariano, Ishtiaq, Sameera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Endocrinology/Diabetes/Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621745/
https://www.ncbi.nlm.nih.gov/pubmed/36340518
http://dx.doi.org/10.7759/cureus.29742
_version_ 1784821612429705216
author Moosa, Syed Ahmad
Mendez, Christian M
Sanchez, Zuleyka
Cabrera, Luis Mariano
Ishtiaq, Sameera
author_facet Moosa, Syed Ahmad
Mendez, Christian M
Sanchez, Zuleyka
Cabrera, Luis Mariano
Ishtiaq, Sameera
author_sort Moosa, Syed Ahmad
collection PubMed
description Antithyroid medications can cause antineutrophil cytoplasmic antibody (ANCA) vasculitis. However, no literature in English describes the coexistence of granulomatosis with polyangiitis (GPA) and untreated Graves’ disease. We present a 19-year-old female with thyroid storm and additional complaints of cough, hemoptysis, nasal discharges, polyarthralgia, and skin lesions. Imaging showed peri-hilar cavities and acute-on-chronic sinusitis. Elevated cytoplasmic pattern antineutrophil cytoplasmic antibody (C-ANCA) and anti-proteinase-3 antibody levels plus histopathology of the nasal and skin biopsies suggested GPA. Propranolol, methimazole, and potassium-iodide resolved the thyroid storm. Induction therapy (steroids, rituximab) for GPA provided relief of chronic symptoms stressing the importance of early recognition and swift initiation of treatment
format Online
Article
Text
id pubmed-9621745
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-96217452022-11-04 Granulomatosis With Polyangiitis in Untreated Graves’ Disease: A Rare Event Moosa, Syed Ahmad Mendez, Christian M Sanchez, Zuleyka Cabrera, Luis Mariano Ishtiaq, Sameera Cureus Endocrinology/Diabetes/Metabolism Antithyroid medications can cause antineutrophil cytoplasmic antibody (ANCA) vasculitis. However, no literature in English describes the coexistence of granulomatosis with polyangiitis (GPA) and untreated Graves’ disease. We present a 19-year-old female with thyroid storm and additional complaints of cough, hemoptysis, nasal discharges, polyarthralgia, and skin lesions. Imaging showed peri-hilar cavities and acute-on-chronic sinusitis. Elevated cytoplasmic pattern antineutrophil cytoplasmic antibody (C-ANCA) and anti-proteinase-3 antibody levels plus histopathology of the nasal and skin biopsies suggested GPA. Propranolol, methimazole, and potassium-iodide resolved the thyroid storm. Induction therapy (steroids, rituximab) for GPA provided relief of chronic symptoms stressing the importance of early recognition and swift initiation of treatment Cureus 2022-09-29 /pmc/articles/PMC9621745/ /pubmed/36340518 http://dx.doi.org/10.7759/cureus.29742 Text en Copyright © 2022, Moosa et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Moosa, Syed Ahmad
Mendez, Christian M
Sanchez, Zuleyka
Cabrera, Luis Mariano
Ishtiaq, Sameera
Granulomatosis With Polyangiitis in Untreated Graves’ Disease: A Rare Event
title Granulomatosis With Polyangiitis in Untreated Graves’ Disease: A Rare Event
title_full Granulomatosis With Polyangiitis in Untreated Graves’ Disease: A Rare Event
title_fullStr Granulomatosis With Polyangiitis in Untreated Graves’ Disease: A Rare Event
title_full_unstemmed Granulomatosis With Polyangiitis in Untreated Graves’ Disease: A Rare Event
title_short Granulomatosis With Polyangiitis in Untreated Graves’ Disease: A Rare Event
title_sort granulomatosis with polyangiitis in untreated graves’ disease: a rare event
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621745/
https://www.ncbi.nlm.nih.gov/pubmed/36340518
http://dx.doi.org/10.7759/cureus.29742
work_keys_str_mv AT moosasyedahmad granulomatosiswithpolyangiitisinuntreatedgravesdiseasearareevent
AT mendezchristianm granulomatosiswithpolyangiitisinuntreatedgravesdiseasearareevent
AT sanchezzuleyka granulomatosiswithpolyangiitisinuntreatedgravesdiseasearareevent
AT cabreraluismariano granulomatosiswithpolyangiitisinuntreatedgravesdiseasearareevent
AT ishtiaqsameera granulomatosiswithpolyangiitisinuntreatedgravesdiseasearareevent

Ejemplares similares