TIGIT Monoallelic Nonsense Variant in Patient with Severe COVID-19 Infection, Thailand

A heterozygous nonsense variant in the TIGIT gene was identified in a patient in Thailand who had severe COVID-19, resulting in lower TIGIT expression in T cells. The patient’s T cells produced higher levels of cytokines upon stimulation. This mutation causes less-controlled immune responses, which...

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Detalles Bibliográficos
Autores principales: Sodsai, Pimpayao, Ittiwut, Chupong, Ruenjaiman, Vichaya, Ittiwut, Rungnapa, Jantarabenjakul, Watsamon, Suphapeetiporn, Kanya, Shotelersuk, Vorasuk, Hirankarn, Nattiya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2022
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622227/
https://www.ncbi.nlm.nih.gov/pubmed/36191906
http://dx.doi.org/10.3201/eid2811.220914
Descripción
Sumario:A heterozygous nonsense variant in the TIGIT gene was identified in a patient in Thailand who had severe COVID-19, resulting in lower TIGIT expression in T cells. The patient’s T cells produced higher levels of cytokines upon stimulation. This mutation causes less-controlled immune responses, which might contribute to COVID-19 severity.

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