TIGIT Monoallelic Nonsense Variant in Patient with Severe COVID-19 Infection, Thailand

A heterozygous nonsense variant in the TIGIT gene was identified in a patient in Thailand who had severe COVID-19, resulting in lower TIGIT expression in T cells. The patient’s T cells produced higher levels of cytokines upon stimulation. This mutation causes less-controlled immune responses, which...

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Autores principales: Sodsai, Pimpayao, Ittiwut, Chupong, Ruenjaiman, Vichaya, Ittiwut, Rungnapa, Jantarabenjakul, Watsamon, Suphapeetiporn, Kanya, Shotelersuk, Vorasuk, Hirankarn, Nattiya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2022
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622227/
https://www.ncbi.nlm.nih.gov/pubmed/36191906
http://dx.doi.org/10.3201/eid2811.220914
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author Sodsai, Pimpayao
Ittiwut, Chupong
Ruenjaiman, Vichaya
Ittiwut, Rungnapa
Jantarabenjakul, Watsamon
Suphapeetiporn, Kanya
Shotelersuk, Vorasuk
Hirankarn, Nattiya
author_facet Sodsai, Pimpayao
Ittiwut, Chupong
Ruenjaiman, Vichaya
Ittiwut, Rungnapa
Jantarabenjakul, Watsamon
Suphapeetiporn, Kanya
Shotelersuk, Vorasuk
Hirankarn, Nattiya
author_sort Sodsai, Pimpayao
collection PubMed
description A heterozygous nonsense variant in the TIGIT gene was identified in a patient in Thailand who had severe COVID-19, resulting in lower TIGIT expression in T cells. The patient’s T cells produced higher levels of cytokines upon stimulation. This mutation causes less-controlled immune responses, which might contribute to COVID-19 severity.
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spelling pubmed-96222272022-11-05 TIGIT Monoallelic Nonsense Variant in Patient with Severe COVID-19 Infection, Thailand Sodsai, Pimpayao Ittiwut, Chupong Ruenjaiman, Vichaya Ittiwut, Rungnapa Jantarabenjakul, Watsamon Suphapeetiporn, Kanya Shotelersuk, Vorasuk Hirankarn, Nattiya Emerg Infect Dis Research Letter A heterozygous nonsense variant in the TIGIT gene was identified in a patient in Thailand who had severe COVID-19, resulting in lower TIGIT expression in T cells. The patient’s T cells produced higher levels of cytokines upon stimulation. This mutation causes less-controlled immune responses, which might contribute to COVID-19 severity. Centers for Disease Control and Prevention 2022-11 /pmc/articles/PMC9622227/ /pubmed/36191906 http://dx.doi.org/10.3201/eid2811.220914 Text en https://creativecommons.org/licenses/by/4.0/Emerging Infectious Diseases is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research Letter
Sodsai, Pimpayao
Ittiwut, Chupong
Ruenjaiman, Vichaya
Ittiwut, Rungnapa
Jantarabenjakul, Watsamon
Suphapeetiporn, Kanya
Shotelersuk, Vorasuk
Hirankarn, Nattiya
TIGIT Monoallelic Nonsense Variant in Patient with Severe COVID-19 Infection, Thailand
title TIGIT Monoallelic Nonsense Variant in Patient with Severe COVID-19 Infection, Thailand
title_full TIGIT Monoallelic Nonsense Variant in Patient with Severe COVID-19 Infection, Thailand
title_fullStr TIGIT Monoallelic Nonsense Variant in Patient with Severe COVID-19 Infection, Thailand
title_full_unstemmed TIGIT Monoallelic Nonsense Variant in Patient with Severe COVID-19 Infection, Thailand
title_short TIGIT Monoallelic Nonsense Variant in Patient with Severe COVID-19 Infection, Thailand
title_sort tigit monoallelic nonsense variant in patient with severe covid-19 infection, thailand
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622227/
https://www.ncbi.nlm.nih.gov/pubmed/36191906
http://dx.doi.org/10.3201/eid2811.220914
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