Sequence-Based Identification of Metronidazole-Resistant Clostridioides difficile Isolates

The plasmid pCD-METRO confers metronidazole resistance in Clostridioides difficile. We showed high sequence similarity among pCD-METRO plasmids from different isolates and identified pCD-METRO and associated metronidazole-resistant isolates in clinical and veterinary reservoirs in the Americas. We r...

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Detalles Bibliográficos
Autores principales: Smits, Wiep Klaas, Harmanus, Céline, Sanders, Ingrid M.J.G., Bry, Lynn, Blackwell, Grace A., Ducarmon, Quinten R., de Oliveira Ferreira, Eliane, Kuijper, Ed J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2022
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622256/
https://www.ncbi.nlm.nih.gov/pubmed/36286226
http://dx.doi.org/10.3201/eid2811.220615
Descripción
Sumario:The plasmid pCD-METRO confers metronidazole resistance in Clostridioides difficile. We showed high sequence similarity among pCD-METRO plasmids from different isolates and identified pCD-METRO and associated metronidazole-resistant isolates in clinical and veterinary reservoirs in the Americas. We recommend using PCR or genomic assays to detect pCD-METRO in metronidazole-resistant C. difficile.

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