Sequence-Based Identification of Metronidazole-Resistant Clostridioides difficile Isolates

The plasmid pCD-METRO confers metronidazole resistance in Clostridioides difficile. We showed high sequence similarity among pCD-METRO plasmids from different isolates and identified pCD-METRO and associated metronidazole-resistant isolates in clinical and veterinary reservoirs in the Americas. We r...

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Autores principales: Smits, Wiep Klaas, Harmanus, Céline, Sanders, Ingrid M.J.G., Bry, Lynn, Blackwell, Grace A., Ducarmon, Quinten R., de Oliveira Ferreira, Eliane, Kuijper, Ed J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2022
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622256/
https://www.ncbi.nlm.nih.gov/pubmed/36286226
http://dx.doi.org/10.3201/eid2811.220615
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author Smits, Wiep Klaas
Harmanus, Céline
Sanders, Ingrid M.J.G.
Bry, Lynn
Blackwell, Grace A.
Ducarmon, Quinten R.
de Oliveira Ferreira, Eliane
Kuijper, Ed J
author_facet Smits, Wiep Klaas
Harmanus, Céline
Sanders, Ingrid M.J.G.
Bry, Lynn
Blackwell, Grace A.
Ducarmon, Quinten R.
de Oliveira Ferreira, Eliane
Kuijper, Ed J
author_sort Smits, Wiep Klaas
collection PubMed
description The plasmid pCD-METRO confers metronidazole resistance in Clostridioides difficile. We showed high sequence similarity among pCD-METRO plasmids from different isolates and identified pCD-METRO and associated metronidazole-resistant isolates in clinical and veterinary reservoirs in the Americas. We recommend using PCR or genomic assays to detect pCD-METRO in metronidazole-resistant C. difficile.
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spelling pubmed-96222562022-11-05 Sequence-Based Identification of Metronidazole-Resistant Clostridioides difficile Isolates Smits, Wiep Klaas Harmanus, Céline Sanders, Ingrid M.J.G. Bry, Lynn Blackwell, Grace A. Ducarmon, Quinten R. de Oliveira Ferreira, Eliane Kuijper, Ed J Emerg Infect Dis Dispatch The plasmid pCD-METRO confers metronidazole resistance in Clostridioides difficile. We showed high sequence similarity among pCD-METRO plasmids from different isolates and identified pCD-METRO and associated metronidazole-resistant isolates in clinical and veterinary reservoirs in the Americas. We recommend using PCR or genomic assays to detect pCD-METRO in metronidazole-resistant C. difficile. Centers for Disease Control and Prevention 2022-11 /pmc/articles/PMC9622256/ /pubmed/36286226 http://dx.doi.org/10.3201/eid2811.220615 Text en https://creativecommons.org/licenses/by/4.0/Emerging Infectious Diseases is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Smits, Wiep Klaas
Harmanus, Céline
Sanders, Ingrid M.J.G.
Bry, Lynn
Blackwell, Grace A.
Ducarmon, Quinten R.
de Oliveira Ferreira, Eliane
Kuijper, Ed J
Sequence-Based Identification of Metronidazole-Resistant Clostridioides difficile Isolates
title Sequence-Based Identification of Metronidazole-Resistant Clostridioides difficile Isolates
title_full Sequence-Based Identification of Metronidazole-Resistant Clostridioides difficile Isolates
title_fullStr Sequence-Based Identification of Metronidazole-Resistant Clostridioides difficile Isolates
title_full_unstemmed Sequence-Based Identification of Metronidazole-Resistant Clostridioides difficile Isolates
title_short Sequence-Based Identification of Metronidazole-Resistant Clostridioides difficile Isolates
title_sort sequence-based identification of metronidazole-resistant clostridioides difficile isolates
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622256/
https://www.ncbi.nlm.nih.gov/pubmed/36286226
http://dx.doi.org/10.3201/eid2811.220615
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